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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editor: Gregory W. Faris
  • Vol. 2, Iss. 9 — Sep. 26, 2007

Coherent femtosecond pulse shaping for the optimization of a non-linear micro-endoscope

M. Lelek, E. Suran, F. Louradour, A. Barthelemy, B. Viellerobe, and F. Lacombe  »View Author Affiliations


Optics Express, Vol. 15, Issue 16, pp. 10154-10162 (2007)
http://dx.doi.org/10.1364/OE.15.010154


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Abstract

A flexible multicore fiber bundle is fed by temporally and spectrally shaped femtosecond pulses allowing for the pre-compensation of both chromatic dispersion and non-linear effects encountered in the bundle. We demonstrate that the pulse duration at the fiber bundle output can be significantly reduced in comparison with linear pre-compensation only. The scheme for femtosecond pulse fiber delivery is applied to the optimization of two-photon fluorescence (TPF) imaging. Experiments and calculations show a five-fold improvement of the TPF signal produced at the end of the fiber bundle in comparison with linear pre-compensation. This is applied to the recording, in real time (12 image/s), of TPF laser-scanning images of human colon cells stained with a fluorescent marker. Further optimizations are discussed.

© 2007 Optical Society of America

OCIS Codes
(060.2350) Fiber optics and optical communications : Fiber optics imaging
(320.5520) Ultrafast optics : Pulse compression
(320.5540) Ultrafast optics : Pulse shaping
(320.7140) Ultrafast optics : Ultrafast processes in fibers

ToC Category:
Ultrafast Optics

History
Original Manuscript: April 6, 2007
Revised Manuscript: June 4, 2007
Manuscript Accepted: June 9, 2007
Published: July 27, 2007

Virtual Issues
Vol. 2, Iss. 9 Virtual Journal for Biomedical Optics

Citation
M. Lelek, E. Suran, F. Louradour, A. Barthelemy, B. Viellerobe, and F. Lacombe, "Coherent femtosecond pulse shaping for the optimization of a non-linear micro-endoscope," Opt. Express 15, 10154-10162 (2007)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=oe-15-16-10154


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