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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editor: Gregory W. Faris
  • Vol. 3, Iss. 1 — Jan. 29, 2008

SERS-based detection in an optofluidic ring resonator platform

Ian. M. White, John Gohring, and Xudong Fan  »View Author Affiliations


Optics Express, Vol. 15, Issue 25, pp. 17433-17442 (2007)
http://dx.doi.org/10.1364/OE.15.017433


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Abstract

The development of surface enhanced Raman scattering (SERS) detection has made Raman spectroscopy relevant for highly sensitive lab-on-a-chip bio/chemical sensors. Despite the tremendous benefit in specificity that a Raman-based sensor can deliver, development of a lab-on-a-chip SERS tool has been limited thus far. In this work, we utilize an optofluidic ring resonator (OFRR) platform to develop a SERS-based detection tool with integrated microfluidics. The liquid core optical ring resonator (LCORR) serves both as the microfluidic sample delivery mechanism and as a ring resonator, exciting the metal nanoclusters and target analytes as they pass through the channel. Using this OFRR approach and R6G as the analyte, we have achieved a measured detection limit of 400 pM. The measured Raman signal in this case is likely generated by only a few hundred R6G molecules, which foreshadows the development of a SERS-based lab-on-a-chip bio/chemical sensor capable of detecting a low number of target analyte molecules.

© 2007 Optical Society of America

OCIS Codes
(130.6010) Integrated optics : Sensors
(140.4780) Lasers and laser optics : Optical resonators
(170.4520) Medical optics and biotechnology : Optical confinement and manipulation
(230.3990) Optical devices : Micro-optical devices
(240.6695) Optics at surfaces : Surface-enhanced Raman scattering

ToC Category:
Sensors

History
Original Manuscript: September 12, 2007
Revised Manuscript: October 22, 2007
Manuscript Accepted: October 22, 2007
Published: December 10, 2007

Virtual Issues
Vol. 3, Iss. 1 Virtual Journal for Biomedical Optics
Physics and Applications of Microresonators (2007) Optics Express

Citation
Ian M. White, John Gohring, and Xudong Fan, "SERS-based detection in an optofluidic ring resonator platform," Opt. Express 15, 17433-17442 (2007)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=oe-15-25-17433


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