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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editor: Gregory W. Faris
  • Vol. 3, Iss. 4 — Apr. 23, 2008

Spectroscopic intravascular photoacoustic imaging to differentiate atherosclerotic plaques

Shriram Sethuraman, James H. Amirian, Silvio H. Litovsky, Richard W. Smalling, and Stanislav Y. Emelianov  »View Author Affiliations


Optics Express, Vol. 16, Issue 5, pp. 3362-3367 (2008)
http://dx.doi.org/10.1364/OE.16.003362


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Abstract

The potential of intravascular photoacoustic (IVPA) imaging to detect atherosclerosis was previously demonstrated using a 532 nm nanosecond pulsed laser and an intravascular ultrasound (IVUS) imaging catheter. However, to differentiate vulnerable plaques, the composition of plaques needs to be imaged. Therefore, we introduce a multi-wavelength photoacoustic imaging method to distinguish various types of plaques. Multi-spectral IVPA imaging of ex vivo samples of normal and atherosclerotic rabbit aorta was performed at several wavelengths within 680–900 nm range. The spectral variation of photoacoustic response was extracted and a spectroscopic analysis was performed. The results of our preliminary study suggest that the spectroscopic intravascular photoacoustic imaging technique can be used to differentiate fibrous and lipid components of the atherosclerotic plaques.

© 2008 Optical Society of America

OCIS Codes
(110.5120) Imaging systems : Photoacoustic imaging
(170.2150) Medical optics and biotechnology : Endoscopic imaging
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(110.4234) Imaging systems : Multispectral and hyperspectral imaging

ToC Category:
Imaging Systems

History
Original Manuscript: December 4, 2007
Revised Manuscript: February 20, 2008
Manuscript Accepted: February 22, 2008
Published: February 28, 2008

Virtual Issues
Vol. 3, Iss. 4 Virtual Journal for Biomedical Optics

Citation
Shriram Sethuraman, James H. Amirian, Silvio H. Litovsky, Richard W. Smalling, and Stanislav Y. Emelianov, "Spectroscopic intravascular photoacoustic imaging to differentiate atherosclerotic plaques," Opt. Express 16, 3362-3367 (2008)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=oe-16-5-3362


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References

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