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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics


  • Editor: Gregory W. Faris
  • Vol. 5, Iss. 1 — Jan. 4, 2010

Intra-retinal layer segmentation in optical coherence tomography images

Akshaya Mishra, Alexander Wong, Kostadinka Bizheva, and David A. Clausi  »View Author Affiliations

Optics Express, Vol. 17, Issue 26, pp. 23719-23728 (2009)

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Retinal layer thickness, evaluated as a function of spatial position from optical coherence tomography (OCT) images is an important diagnostics marker for many retinal diseases. However, due to factors such as speckle noise, low image contrast, irregularly shaped morphological features such as retinal detachments, macular holes, and drusen, accurate segmentation of individual retinal layers is difficult. To address this issue, a computer method for retinal layer segmentation from OCT images is presented. An efficient two-step kernel-based optimization scheme is employed to first identify the approximate locations of the individual layers, which are then refined to obtain accurate segmentation results for the individual layers. The performance of the algorithm was tested on a set of retinal images acquired in-vivo from healthy and diseased rodent models with a high speed, high resolution OCT system. Experimental results show that the proposed approach provides accurate segmentation for OCT images affected by speckle noise, even in sub-optimal conditions of low image contrast and presence of irregularly shaped structural features in the OCT images.

© 2009 Optical Society of America

OCIS Codes
(100.0100) Image processing : Image processing
(170.4500) Medical optics and biotechnology : Optical coherence tomography
(170.4580) Medical optics and biotechnology : Optical diagnostics for medicine
(100.3008) Image processing : Image recognition, algorithms and filters

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: September 18, 2009
Revised Manuscript: October 26, 2009
Manuscript Accepted: November 20, 2009
Published: December 11, 2009

Virtual Issues
Vol. 5, Iss. 1 Virtual Journal for Biomedical Optics

Akshaya Mishra, Alexander Wong, Kostadinka Bizheva, and David A. Clausi, "Intra-retinal layer segmentation in optical coherence tomography images," Opt. Express 17, 23719-23728 (2009)

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