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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editor: Gregory W. Faris
  • Vol. 5, Iss. 10 — Jul. 19, 2010

Reference optical phantoms for diffuse optical spectroscopy. Part 1 – Error analysis of a time resolved transmittance characterization method

Jean-Pierre Bouchard, Israël Veilleux, Rym Jedidi, Isabelle Noiseux, Michel Fortin, and Ozzy Mermut  »View Author Affiliations


Optics Express, Vol. 18, Issue 11, pp. 11495-11507 (2010)
http://dx.doi.org/10.1364/OE.18.011495


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Abstract

Development, production quality control and calibration of optical tissue-mimicking phantoms require a convenient and robust characterization method with known absolute accuracy. We present a solid phantom characterization technique based on time resolved transmittance measurement of light through a relatively small phantom sample. The small size of the sample enables characterization of every material batch produced in a routine phantoms production. Time resolved transmittance data are pre-processed to correct for dark noise, sample thickness and instrument response function. Pre-processed data are then compared to a forward model based on the radiative transfer equation solved through Monte Carlo simulations accurately taking into account the finite geometry of the sample. The computational burden of the Monte-Carlo technique was alleviated by building a lookup table of pre-computed results and using interpolation to obtain modeled transmittance traces at intermediate values of the optical properties. Near perfect fit residuals are obtained with a fit window using all data above 1% of the maximum value of the time resolved transmittance trace. Absolute accuracy of the method is estimated through a thorough error analysis which takes into account the following contributions: measurement noise, system repeatability, instrument response function stability, sample thickness variation refractive index inaccuracy, time correlated single photon counting system time based inaccuracy and forward model inaccuracy. Two sigma absolute error estimates of 0.01 cm−1 (11.3%) and 0.67 cm−1 (6.8%) are obtained for the absorption coefficient and reduced scattering coefficient respectively.

© 2010 OSA

OCIS Codes
(120.3890) Instrumentation, measurement, and metrology : Medical optics instrumentation
(170.6510) Medical optics and biotechnology : Spectroscopy, tissue diagnostics

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: March 10, 2010
Revised Manuscript: April 22, 2010
Manuscript Accepted: May 6, 2010
Published: May 14, 2010

Virtual Issues
Vol. 5, Iss. 10 Virtual Journal for Biomedical Optics

Citation
Jean-Pierre Bouchard, Israël Veilleux, Rym Jedidi, Isabelle Noiseux, Michel Fortin, and Ozzy Mermut, "Reference optical phantoms for diffuse optical spectroscopy. Part 1 – Error analysis of a time resolved transmittance characterization method," Opt. Express 18, 11495-11507 (2010)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=oe-18-11-11495


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