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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editor: Gregory W. Faris
  • Vol. 5, Iss. 10 — Jul. 19, 2010

Selective imaging of nano-particle contrast agents by a single-shot x-ray diffraction technique

Ashley F. Stein, Jan Ilavsky, Rael Kopace, Eric E. Bennett, and Han Wen  »View Author Affiliations


Optics Express, Vol. 18, Issue 12, pp. 13271-13278 (2010)
http://dx.doi.org/10.1364/OE.18.013271


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Abstract

Iron oxide nano-particles have very different x-ray diffraction properties from tissue. They can be clearly visualized against suppressed tissue background in a single-shot x-ray diffraction imaging technique. This technique is able to acquire both diffraction and absorption images from a single grating-modulated projection image through analysis in the spatial frequency domain. We describe the use of two orthogonal transmission gratings to selectively retain diffraction signal from iron oxide particles that are larger than a threshold size, while eliminating the background signal from soft tissue and bone. This approach should help the tracking of functionalized particles in cell labeling and targeted therapy.

© 2010 OSA

OCIS Codes
(170.7440) Medical optics and biotechnology : X-ray imaging
(340.7450) X-ray optics : X-ray interferometry
(110.2650) Imaging systems : Fringe analysis

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: April 29, 2010
Revised Manuscript: June 1, 2010
Manuscript Accepted: June 1, 2010
Published: June 4, 2010

Virtual Issues
Vol. 5, Iss. 10 Virtual Journal for Biomedical Optics

Citation
Ashley F. Stein, Jan Ilavsky, Rael Kopace, Eric E. Bennett, and Han Wen, "Selective imaging of nano-particle contrast agents by a single-shot x-ray diffraction technique," Opt. Express 18, 13271-13278 (2010)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=oe-18-12-13271


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