Selective imaging of nano-particle contrast agents by a single-shot x-ray diffraction technique

doi:10.1364/OE.18.013271

Selective imaging of nano-particle contrast agents by a single-shot x-ray diffraction technique

Ashley F. Stein, Jan Ilavsky, Rael Kopace, Eric E. Bennett, and Han Wen »View Author Affiliations

Optics Express, Vol. 18, Issue 12, pp. 13271-13278 (2010)
http://dx.doi.org/10.1364/OE.18.013271

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Abstract
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References (12)
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Abstract

Iron oxide nano-particles have very different x-ray diffraction properties from tissue. They can be clearly visualized against suppressed tissue background in a single-shot x-ray diffraction imaging technique. This technique is able to acquire both diffraction and absorption images from a single grating-modulated projection image through analysis in the spatial frequency domain. We describe the use of two orthogonal transmission gratings to selectively retain diffraction signal from iron oxide particles that are larger than a threshold size, while eliminating the background signal from soft tissue and bone. This approach should help the tracking of functionalized particles in cell labeling and targeted therapy.

OCIS Codes
(170.7440) Medical optics and biotechnology : X-ray imaging
(340.7450) X-ray optics : X-ray interferometry
(110.2650) Imaging systems : Fringe analysis

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: April 29, 2010
Revised Manuscript: June 1, 2010
Manuscript Accepted: June 1, 2010
Published: June 4, 2010

Virtual Issues
Vol. 5, Iss. 10 Virtual Journal for Biomedical Optics

Citation
Ashley F. Stein, Jan Ilavsky, Rael Kopace, Eric E. Bennett, and Han Wen, "Selective imaging of nano-particle contrast agents by a single-shot x-ray diffraction technique," Opt. Express 18, 13271-13278 (2010)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=oe-18-12-13271

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References

S. Yokozeki and T. Suzuki, “Shearing Interferometer Using the Grating as the Beam Splitter,” Appl. Opti. 10(7), 1575-1580 (1971).
A. Momose, S. Kawamoto, I. Koyama, Y. Hamaishi, K. Takai, and Y. Suzuki, “Demonstration of X-Ray Talbot interferometry,” Japanese J. Appl. Phys. Part 2-Letters 42, L866–L868 (2003).
C. David, B. Nohammer, H. H. Solak, and E. Ziegler, “Differential x-ray phase contrast imaging using a shearing interferometer,” Appl. Phys. Lett. 81(17), 3287–3289 (2002). [CrossRef]
T. Weitkamp, A. Diaz, C. David, F. Pfeiffer, M. Stampanoni, P. Cloetens, and E. Ziegler, “X-ray phase imaging with a grating interferometer,” Opt. Express 13(16), 6296–6304 (2005). [CrossRef] [PubMed]
F. Pfeiffer, M. Bech, O. Bunk, P. Kraft, E. F. Eikenberry, Ch. Brönnimann, C. Grünzweig, and C. David, “Hard-X-ray dark-field imaging using a grating interferometer,” Nat. Mater. 7(2), 134–137 (2008). [CrossRef] [PubMed]
Y. Takeda, W. Yashiro, Y. Suzuki, S. Aoki, T. Hattori, and A. Momose, “X-ray phase imaging with single phase grating,” Japanese J. Appl. Phys. Part 2-Letters & Express Letters 46, L89–L91 (2007).
H. Wen, E. E. Bennett, M. M. Hegedus, and S. C. Carroll, “Spatial harmonic imaging of X-ray scattering--initial results,” IEEE Trans. Med. Imaging 27(8), 997–1002 (2008). [CrossRef] [PubMed]
H. Wen, E. E. Bennett, M. M. Hegedus, and S. Rapacchi, “Fourier X-ray scattering radiography yields bone structural information,” Radiology 251(3), 910–918 (2009). [CrossRef] [PubMed]
L. E. Levine and G. G. Long, “X-ray imaging with ultra-small-angle x-ray scattering as a contrast mechanism,” J. Appl. Cryst. 37(5), 757–765 (2004). [CrossRef]
J. Ilavsky, P. R. Jemian, A. J. Allen, F. Zhang, L. E. Levine, and G. G. Long, “Ultra-small-angle X-ray scattering at the Advanced Photon Source,” J. Appl. Cryst. 42(3), 469–479 (2009). [CrossRef]
P. C. Johns and M. J. Yaffe, “Coherent scatter in diagnostic radiology,” Med. Phys. 10(1), 40–50 (1983). [CrossRef] [PubMed]
Q. A. Pankhurst, J. Connolly, S. K. Jones, and J. Dobson, “Applications of magnetic nanoparticles in biomedicine,” J. Phys. D Appl. Phys. 36(13), R167–R181 (2003). [CrossRef]

Allen, A. J.
Aoki, S.
Bech, M.
Bennett, E. E.
Brönnimann, Ch.
Bunk, O.
Carroll, S. C.
Cloetens, P.
Connolly, J.
David, C.
Diaz, A.
Dobson, J.
Eikenberry, E. F.
Grünzweig, C.
Hamaishi, Y.
Hattori, T.
Hegedus, M. M.
Ilavsky, J.
Jemian, P. R.
Johns, P. C.
Jones, S. K.
Kawamoto, S.
Koyama, I.
Kraft, P.
Levine, L. E.
Long, G. G.
Momose, A.
Nohammer, B.
Pankhurst, Q. A.
Pfeiffer, F.
Rapacchi, S.
Solak, H. H.
Stampanoni, M.
Suzuki, T.
Suzuki, Y.
Takai, K.
Takeda, Y.
Weitkamp, T.
Wen, H.
Yaffe, M. J.
Yashiro, W.
Yokozeki, S.
Zhang, F.
Ziegler, E.

Appl. Phys. Lett.

C. David, B. Nohammer, H. H. Solak, and E. Ziegler, “Differential x-ray phase contrast imaging using a shearing interferometer,” Appl. Phys. Lett. 81(17), 3287–3289 (2002). [CrossRef]

IEEE Trans. Med. Imaging

H. Wen, E. E. Bennett, M. M. Hegedus, and S. C. Carroll, “Spatial harmonic imaging of X-ray scattering--initial results,” IEEE Trans. Med. Imaging 27(8), 997–1002 (2008). [CrossRef] [PubMed]

J. Appl. Cryst.

L. E. Levine and G. G. Long, “X-ray imaging with ultra-small-angle x-ray scattering as a contrast mechanism,” J. Appl. Cryst. 37(5), 757–765 (2004). [CrossRef]
J. Ilavsky, P. R. Jemian, A. J. Allen, F. Zhang, L. E. Levine, and G. G. Long, “Ultra-small-angle X-ray scattering at the Advanced Photon Source,” J. Appl. Cryst. 42(3), 469–479 (2009). [CrossRef]

J. Phys. D Appl. Phys.

Q. A. Pankhurst, J. Connolly, S. K. Jones, and J. Dobson, “Applications of magnetic nanoparticles in biomedicine,” J. Phys. D Appl. Phys. 36(13), R167–R181 (2003). [CrossRef]

Med. Phys.

P. C. Johns and M. J. Yaffe, “Coherent scatter in diagnostic radiology,” Med. Phys. 10(1), 40–50 (1983). [CrossRef] [PubMed]

Nat. Mater.

F. Pfeiffer, M. Bech, O. Bunk, P. Kraft, E. F. Eikenberry, Ch. Brönnimann, C. Grünzweig, and C. David, “Hard-X-ray dark-field imaging using a grating interferometer,” Nat. Mater. 7(2), 134–137 (2008). [CrossRef] [PubMed]

Opt. Express

T. Weitkamp, A. Diaz, C. David, F. Pfeiffer, M. Stampanoni, P. Cloetens, and E. Ziegler, “X-ray phase imaging with a grating interferometer,” Opt. Express 13(16), 6296–6304 (2005). [CrossRef] [PubMed]

Radiology

H. Wen, E. E. Bennett, M. M. Hegedus, and S. Rapacchi, “Fourier X-ray scattering radiography yields bone structural information,” Radiology 251(3), 910–918 (2009). [CrossRef] [PubMed]

Other

Y. Takeda, W. Yashiro, Y. Suzuki, S. Aoki, T. Hattori, and A. Momose, “X-ray phase imaging with single phase grating,” Japanese J. Appl. Phys. Part 2-Letters & Express Letters 46, L89–L91 (2007).
S. Yokozeki and T. Suzuki, “Shearing Interferometer Using the Grating as the Beam Splitter,” Appl. Opti. 10(7), 1575-1580 (1971).
A. Momose, S. Kawamoto, I. Koyama, Y. Hamaishi, K. Takai, and Y. Suzuki, “Demonstration of X-Ray Talbot interferometry,” Japanese J. Appl. Phys. Part 2-Letters 42, L866–L868 (2003).

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[1] S. Yokozeki and T. Suzuki, “Shearing Interferometer Using the Grating as the Beam Splitter,” Appl. Opti. 10(7), 1575-1580 (1971).

[2] A. Momose, S. Kawamoto, I. Koyama, Y. Hamaishi, K. Takai, and Y. Suzuki, “Demonstration of X-Ray Talbot interferometry,” Japanese J. Appl. Phys. Part 2-Letters 42, L866–L868 (2003).

[3] C. David, B. Nohammer, H. H. Solak, and E. Ziegler, “Differential x-ray phase contrast imaging using a shearing interferometer,” Appl. Phys. Lett. 81(17), 3287–3289 (2002). [CrossRef]

[4] T. Weitkamp, A. Diaz, C. David, F. Pfeiffer, M. Stampanoni, P. Cloetens, and E. Ziegler, “X-ray phase imaging with a grating interferometer,” Opt. Express 13(16), 6296–6304 (2005). [CrossRef] [PubMed]

[5] F. Pfeiffer, M. Bech, O. Bunk, P. Kraft, E. F. Eikenberry, Ch. Brönnimann, C. Grünzweig, and C. David, “Hard-X-ray dark-field imaging using a grating interferometer,” Nat. Mater. 7(2), 134–137 (2008). [CrossRef] [PubMed]

[6] Y. Takeda, W. Yashiro, Y. Suzuki, S. Aoki, T. Hattori, and A. Momose, “X-ray phase imaging with single phase grating,” Japanese J. Appl. Phys. Part 2-Letters & Express Letters 46, L89–L91 (2007).

[7] H. Wen, E. E. Bennett, M. M. Hegedus, and S. C. Carroll, “Spatial harmonic imaging of X-ray scattering--initial results,” IEEE Trans. Med. Imaging 27(8), 997–1002 (2008). [CrossRef] [PubMed]

[8] H. Wen, E. E. Bennett, M. M. Hegedus, and S. Rapacchi, “Fourier X-ray scattering radiography yields bone structural information,” Radiology 251(3), 910–918 (2009). [CrossRef] [PubMed]

[9] L. E. Levine and G. G. Long, “X-ray imaging with ultra-small-angle x-ray scattering as a contrast mechanism,” J. Appl. Cryst. 37(5), 757–765 (2004). [CrossRef]

[10] J. Ilavsky, P. R. Jemian, A. J. Allen, F. Zhang, L. E. Levine, and G. G. Long, “Ultra-small-angle X-ray scattering at the Advanced Photon Source,” J. Appl. Cryst. 42(3), 469–479 (2009). [CrossRef]

[11] P. C. Johns and M. J. Yaffe, “Coherent scatter in diagnostic radiology,” Med. Phys. 10(1), 40–50 (1983). [CrossRef] [PubMed]

[12] Q. A. Pankhurst, J. Connolly, S. K. Jones, and J. Dobson, “Applications of magnetic nanoparticles in biomedicine,” J. Phys. D Appl. Phys. 36(13), R167–R181 (2003). [CrossRef]

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Selective imaging of nano-particle contrast agents by a single-shot x-ray diffraction technique