OSA's Digital Library

Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editors: Andrew Dunn and Anthony Durkin
  • Vol. 6, Iss. 1 — Jan. 3, 2011

Polarized near-infrared autofluorescence imaging combined with near-infrared diffuse reflectance imaging for improving colonic cancer detection

Xiaozhuo Shao, Wei Zheng, and Zhiwei Huang  »View Author Affiliations


Optics Express, Vol. 18, Issue 23, pp. 24293-24300 (2010)
http://dx.doi.org/10.1364/OE.18.024293


View Full Text Article

Enhanced HTML    Acrobat PDF (1204 KB) Open Access





Browse Journals / Lookup Meetings

Browse by Journal and Year


   


Lookup Conference Papers

Close Browse Journals / Lookup Meetings

Article Tools

Share
Citations

Abstract

We evaluate the diagnostic feasibility of the integrated polarized near-infrared (NIR) autofluorescence (AF) and NIR diffuse reflectance (DR) imaging technique developed for colonic cancer detection. A total of 48 paired colonic tissue specimens (normal vs. cancer) were measured using the integrated NIR DR (850-1100 nm) and NIR AF imaging at the 785 nm laser excitation. The results showed that NIR AF intensities of cancer tissues are significantly lower than those of normal tissues (p<0.001, paired 2-sided Student’s t-test, n = 48). NIR AF imaging under polarization conditions gives a higher diagnostic accuracy (of ~92-94%) compared to non-polarized NIR AF imaging or NIR DR imaging. Further, the ratio imaging of NIR DR to NIR AF with polarization provides the best diagnostic accuracy (of ~96%) among the NIR AF and NIR DR imaging techniques. This work suggests that the integrated NIR AF/DR imaging under polarization condition has the potential to improve the early diagnosis and detection of malignant lesions in the colon.

© 2010 OSA

OCIS Codes
(170.0110) Medical optics and biotechnology : Imaging systems
(170.3890) Medical optics and biotechnology : Medical optics instrumentation
(170.4580) Medical optics and biotechnology : Optical diagnostics for medicine

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: August 9, 2010
Revised Manuscript: September 13, 2010
Manuscript Accepted: October 24, 2010
Published: November 5, 2010

Virtual Issues
Vol. 6, Iss. 1 Virtual Journal for Biomedical Optics

Citation
Xiaozhuo Shao, Wei Zheng, and Zhiwei Huang, "Polarized near-infrared autofluorescence imaging combined with near-infrared diffuse reflectance imaging for improving colonic cancer detection," Opt. Express 18, 24293-24300 (2010)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=oe-18-23-24293


Sort:  Author  |  Year  |  Journal  |  Reset  

References

  1. A. Jemal, R. Siegel, E. Ward, Y. Hao, J. Xu, and M. J. Thun, “Cancer statistics, 2009,” CA Cancer J. Clin. 59(4), 225–249 (2009). [CrossRef] [PubMed]
  2. W. Du, J. T. L. Mah, J. Lee, R. Sankila, R. Sankaranarayanan, and K. S. Chia, “Incidence and survival of mucinous adenocarcinoma of the colorectum: a population-based study from an Asian country,” Dis. Colon Rectum 47(1), 78–85 (2004). [CrossRef] [PubMed]
  3. R. M. Soetikno, T. Kaltenbach, R. V. Rouse, W. Park, A. Maheshwari, T. Sato, S. Matsui, and S. Friedland, “Prevalence of nonpolypoid (flat and depressed) colorectal neoplasms in asymptomatic and symptomatic adults,” JAMA 299(9), 1027–1035 (2008). [CrossRef] [PubMed]
  4. R. Kiesslich, A. Hoffman, and M. F. Neurath, “Colonoscopy, tumors, and inflammatory bowel disease - new diagnostic methods,” Endoscopy 38(1), 5–10 (2006). [CrossRef] [PubMed]
  5. A. L. McCallum, J. T. Jenkins, D. Gillen, and R. G. Molloy, “Evaluation of autofluorescence colonoscopy for the detection and diagnosis of colonic polyps,” Gastrointest. Endosc. 68(2), 283–290 (2008). [CrossRef] [PubMed]
  6. G. J. E. Brown and B. P. Saunders, “Advances in colonic imaging: technical improvements in colonoscopy,” Eur. J. Gastroenterol. Hepatol. 17(8), 785–792 (2005). [CrossRef] [PubMed]
  7. S. Anandasabapathy, “Endoscopic imaging: emerging optical techniques for the detection of colorectal neoplasia,” Curr. Opin. Gastroenterol. 24(1), 64–69 (2008). [CrossRef]
  8. T. D. Wang and G. Triadafilopoulos, “Autofluorescence imaging: have we finally seen the light?” Gastrointest. Endosc. 61(6), 686–688 (2005). [CrossRef] [PubMed]
  9. J. Hung, S. Lam, J. C. LeRiche, and B. Palcic, “Autofluorescence of normal and malignant bronchial tissue,” Lasers Surg. Med. 11(2), 99–105 (1991). [CrossRef] [PubMed]
  10. D. Roblyer, R. Richards-Kortum, K. Sokolov, A. K. El-Naggar, M. D. Williams, C. Kurachi, and A. M. Gillenwater, “Multispectral optical imaging device for in vivo detection of oral neoplasia,” J. Biomed. Opt. 13(2), 024019 (2008). [CrossRef] [PubMed]
  11. D. Pantalone, F. Andreoli, F. Fusi, V. Basile, G. Romano, G. Giustozzi, L. Rigacci, R. Alterini, and M. Monici, “Multispectral imaging autofluorescence microscopy in colonic and gastric cancer metastatic lymph nodes,” Clin. Gastroenterol. Hepatol. 5(2), 230–236 (2007). [CrossRef] [PubMed]
  12. W. R. Kessler, “Autofluorescence colonoscopy: a green light on the long road to “real-time” histology,” Gastrointest. Endosc. 68(2), 291–293 (2008). [CrossRef] [PubMed]
  13. R. Richards-Kortum, R. P. Rava, R. E. Petras, M. Fitzmaurice, M. Sivak, and M. S. Feld, “Spectroscopic diagnosis of colonic dysplasia,” Photochem. Photobiol. 53(6), 777–786 (1991). [PubMed]
  14. K. T. Schomacker, J. K. Frisoli, C. C. Compton, T. J. Flotte, J. M. Richter, N. S. Nishioka, and T. F. Deutsch, “Ultraviolet laser-induced fluorescence of colonic tissue: basic biology and diagnostic potential,” Lasers Surg. Med. 12(1), 63–78 (1992). [CrossRef] [PubMed]
  15. H. Aihara, K. Sumiyama, S. Saito, H. Tajiri, and M. Ikegami, “Numerical analysis of the autofluorescence intensity of neoplastic and non-neoplastic colorectal lesions by using a novel videoendoscopy system,” Gastrointest. Endosc. 69(3 Pt 2), 726–733 (2009). [CrossRef] [PubMed]
  16. X. Han, H. Lui, D. I. McLean, and H. Zeng, “Near-infrared autofluorescence imaging of cutaneous melanins and human skin in vivo,” J. Biomed. Opt. 14(2), 024017 (2009). [CrossRef] [PubMed]
  17. Z. Huang, H. Zeng, I. Hamzavi, A. Alajlan, E. Tan, D. I. McLean, and H. Lui, “Cutaneous melanin exhibiting fluorescence emission under near-infrared light excitation,” J. Biomed. Opt. 11(3), 34010 (2006). [CrossRef] [PubMed]
  18. Z. Huang, H. Lui, D. I. McLean, M. Korbelik, and H. Zeng, “Raman spectroscopy in combination with background near-infrared autofluorescence enhances the in vivo assessment of malignant tissues,” Photochem. Photobiol. 81(5), 1219–1226 (2005). [CrossRef] [PubMed]
  19. E. B. Hanlon, I. Itzkan, R. R. Dasari, M. S. Feld, R. J. Ferrante, A. C. McKee, D. Lathi, and N. W. Kowall, “Near-infrared fluorescence spectroscopy detects Alzheimer’s disease in vitro,” Photochem. Photobiol. 70(2), 236–242 (1999). [PubMed]
  20. Z. Huang, W. Zheng, S. Xie, R. Chen, H. Zeng, D. I. McLean, and H. Lui, “Laser-induced autofluorescence microscopy of normal and tumor human colonic tissue,” Int. J. Oncol. 24(1), 59–63 (2004).
  21. G. I. Zonios, R. M. Cothren, J. T. Arendt, J. Wu, J. Van Dam, J. M. Crawford, R. Manoharan, and M. S. Feld, “Morphological model of human colon tissue fluorescence,” IEEE Trans. Biomed. Eng. 43(2), 113–122 (1996). [CrossRef] [PubMed]
  22. R. Drezek, K. Sokolov, U. Utzinger, I. Boiko, A. Malpica, M. Follen, and R. Richards-Kortum, “Understanding the contributions of NADH and collagen to cervical tissue fluorescence spectra: modeling, measurements, and implications,” J. Biomed. Opt. 6(4), 385–396 (2001). [CrossRef] [PubMed]
  23. S. L. Jacques, J. R. Roman, and K. Lee, “Imaging superficial tissues with polarized light,” Lasers Surg. Med. 26(2), 119–129 (2000). [CrossRef] [PubMed]
  24. X. Wang and L. V. Wang, “Propagation of polarized light in birefringent turbid media: a Monte Carlo study,” J. Biomed. Opt. 7(3), 279–290 (2002). [CrossRef] [PubMed]
  25. J. Y. Qu, J. Hua, and Z. Huang, “Correction of geometrical effects on fluorescence imaging of tissue,” Opt. Commun. 176, 319–326 (2000). [CrossRef]

Cited By

Alert me when this paper is cited

OSA is able to provide readers links to articles that cite this paper by participating in CrossRef's Cited-By Linking service. CrossRef includes content from more than 3000 publishers and societies. In addition to listing OSA journal articles that cite this paper, citing articles from other participating publishers will also be listed.


« Previous Article  |  Next Article »

OSA is a member of CrossRef.

CrossCheck Deposited