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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editors: Andrew Dunn and Anthony Durkin
  • Vol. 6, Iss. 10 — Nov. 2, 2011

Differing self-similarity in light scattering spectra: a potential tool for pre-cancer detection

Sayantan Ghosh, Jalpa Soni, Harsh Purwar, Jaidip Jagtap, Asima Pradhan, Nirmalya Ghosh, and Prasanta K. Panigrahi  »View Author Affiliations


Optics Express, Vol. 19, Issue 20, pp. 19717-19730 (2011)
http://dx.doi.org/10.1364/OE.19.019717


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Abstract

The fluctuations in the elastic light scattering spectra of normal and dysplastic human cervical tissues analyzed through wavelet transform based techniques reveal clear signatures of self-similar behavior in the spectral fluctuations. The values of the scaling exponent observed for these tissues indicate the differences in the self-similarity for dysplastic tissues and their normal counterparts. The strong dependence of the elastic light scattering on the size distribution of the scatterers manifests in the angular variation of the scaling exponent. Interestingly, the spectral fluctuations in both these tissues showed multi-fractality (non-stationarity in fluctuations), the degree of multi-fractality being marginally higher in the case of dysplastic tissues. These findings using the multi-resolution analysis capability of the discrete wavelet transform can contribute to the recent surge in the exploration for non-invasive optical tools for pre-cancer detection.

© 2011 OSA

OCIS Codes
(100.7410) Image processing : Wavelets
(170.4580) Medical optics and biotechnology : Optical diagnostics for medicine
(290.0290) Scattering : Scattering
(170.6935) Medical optics and biotechnology : Tissue characterization

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: July 14, 2011
Revised Manuscript: August 23, 2011
Manuscript Accepted: August 25, 2011
Published: September 23, 2011

Virtual Issues
Vol. 6, Iss. 10 Virtual Journal for Biomedical Optics

Citation
Sayantan Ghosh, Jalpa Soni, Harsh Purwar, Jaidip Jagtap, Asima Pradhan, Nirmalya Ghosh, and Prasanta K. Panigrahi, "Differing self-similarity in light scattering spectra: a potential tool for pre-cancer detection," Opt. Express 19, 19717-19730 (2011)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=oe-19-20-19717


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