Optics InfoBase > Virtual Journal for Biomedical Optics > Volume 7 > Issue 2 > Page 26672
|
|
Supercontinuum generation for coherent anti-Stokes Raman scattering microscopy with photonic crystal fibersPernille Klarskov, Antti Isomäki, Kim P. Hansen, and Peter E. Andersen »View Author Affiliations
Pernille Klarskov,1,*
Antti Isomäki,1
Kim P. Hansen,2
and Peter E. Andersen1
1DTU Fotonik, Department of Photonics Engineering, Technical University of Denmark, Frederiksborgvej 399, 4000 Roskilde, Denmark 2NKT Photonics A/S, Blokken 84, DK-3460 Birkerød, Denmark *Corresponding author: pkpe@fotonik.dtu.dk |
Optics Express, Vol. 19, Issue 27, pp. 26672-26683 (2011)
http://dx.doi.org/10.1364/OE.19.026672
View Full Text Article
Enhanced HTML
Acrobat PDF (1578 KB)
Abstract
Photonic crystal fiber (PCF) designs with two zero-dispersion wavelengths (ZDWs) are experimentally investigated in order to suggest a novel PCF for coherent anti-Stokes Raman scattering (CARS) microscopy. From our investigation, we select the optimum PCF design and demonstrate a tailored spectrum with power concentrated around the relevant wavelengths for lipid imaging (648 nm and 1027 nm). This new PCF is characterized by varying the fiber length, the average power, and the pulse width of the fs pump pulses. It was found that the selected PCF design gave a significantly improved spectral distribution compared to an existing PCF for CARS microscopy. Furthermore, the PCF is designed in a twofold symmetric structure allowing for polarization maintaining propagation. Finally, the pulse propagation is investigated numerically showing good agreement with the measured spectrum. From the numerical analysis, the nonlinear effects responsible for the spectral broadening are explained to be soliton fission processes, dispersive waves, and stimulated Raman scattering.
© 2011 OSA
OCIS Codes
(060.4370) Fiber optics and optical communications : Nonlinear optics, fibers
(190.5530) Nonlinear optics : Pulse propagation and temporal solitons
(300.6230) Spectroscopy : Spectroscopy, coherent anti-Stokes Raman scattering
(060.4005) Fiber optics and optical communications : Microstructured fibers
(320.6629) Ultrafast optics : Supercontinuum generation
ToC Category:
Fiber Optics and Optical Communications
History
Original Manuscript: October 17, 2011
Revised Manuscript: December 2, 2011
Manuscript Accepted: December 5, 2011
Published: December 14, 2011
Virtual Issues
Vol. 7, Iss. 2 Virtual Journal for Biomedical Optics
Citation
Pernille Klarskov, Antti Isomäki, Kim P. Hansen, and Peter E. Andersen, "Supercontinuum generation for coherent anti-Stokes Raman scattering microscopy with photonic crystal fibers," Opt. Express 19, 26672-26683 (2011)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=oe-19-27-26672
Sort: Author | Year | Journal | Reset
References
- R. F. Begley, A. B. Harvey, and R. L. Byer, “Coherent anti-Stokes Raman spectroscopy,” Appl. Phys. Lett.25(7), 387–390 (1974). [CrossRef]
- J. Imitola, D. Côté, S. Rasmussen, X. S. Xie, Y. Liu, T. Chitnis, R. L. Sidman, C. P. Lin, and S. J. Khoury, “Multimodal coherent anti-Stokes Raman scattering microscopy reveals microglia-associated myelin and axonal dysfunction in multiple sclerosis-like lesions in mice,” J. Biomed. Opt.16(2), 021109 (2011). [CrossRef] [PubMed]
- A. C. T. Ko, A. Ridsdale, M. S. D. Smith, L. B. Mostaco-Guidolin, M. D. Hewko, A. F. Pegoraro, E. K. Kohlenberg, B. Schattka, M. Shiomi, A. Stolow, and M. G. Sowa, “Multimodal nonlinear optical imaging of atherosclerotic plaque development in myocardial infarction-prone rabbits,” J. Biomed. Opt.15(2), 020501 (2010). [CrossRef] [PubMed]
- R. K. Lyn, D. C. Kennedy, S. M. Sagan, D. R. Blais, Y. Rouleau, A. F. Pegoraro, X. S. Xie, A. Stolow, and J. P. Pezacki, “Direct imaging of the disruption of hepatitis C virus replication complexes by inhibitors of lipid metabolism,” Virology394(1), 130–142 (2009). [CrossRef] [PubMed]
- X. Nan, A. M. Tonary, A. Stolow, X. S. Xie, and J. P. Pezacki, “Intracellular imaging of HCV RNA and cellular lipids by using simultaneous two-photon fluorescence and coherent anti-Stokes Raman scattering microscopies,” ChemBioChem7(12), 1895–1897 (2006). [CrossRef] [PubMed]
- K. Wang, C. W. Freudiger, J. H. Lee, B. G. Saar, X. S. Xie, and C. Xu, “Synchronized time-lens source for coherent Raman scattering microscopy,” Opt. Express18(23), 24019–24024 (2010). [CrossRef] [PubMed]
- R. S. Lim, A. Kratzer, N. P. Barry, S. Miyazaki-Anzai, M. Miyazaki, W. W. Mantulin, M. Levi, E. O. Potma, and B. J. Tromberg, “Multimodal CARS microscopy determination of the impact of diet on macrophage infiltration and lipid accumulation on plaque formation in ApoE-deficient mice,” J. Lipid Res.51(7), 1729–1737 (2010). [CrossRef] [PubMed]
- Y. Zeng, B. Saar, M. Friedrich, F. Chen, Y.-S. Liu, R. Dixon, M. Himmel, X. Xie, and S.-Y. Ding, “Imaging lignin-downregulated alfalfa using coherent anti-Stokes Raman scattering microscopy,” BioEnergy Res.3(3), 272–277 (2010). [CrossRef]
- G. Agrawal, Nonlinear Fiber Optics, 3rd ed. (Academics Press, 2001).
- P. Russell, “Photonic crystal fibers,” Science299(5605), 358–362 (2003). [CrossRef] [PubMed]
- J. K. Ranka, R. S. Windeler, and A. J. Stentz, “Optical properties of high-delta air silica microstructure optical fibers,” Opt. Lett.25(11), 796–798 (2000). [CrossRef] [PubMed]
- K. M. Hilligsøe, T. Andersen, H. Paulsen, C. Nielsen, K. Mølmer, S. Keiding, R. Kristiansen, K. Hansen, and J. Larsen, “Supercontinuum generation in a photonic crystal fiber with two zero dispersion wavelengths,” Opt. Express12(6), 1045–1054 (2004). [CrossRef] [PubMed]
- I. Hartl, X. D. Li, C. Chudoba, R. K. Ghanta, T. H. Ko, J. G. Fujimoto, J. K. Ranka, and R. S. Windeler, “Ultrahigh-resolution optical coherence tomography using continuum generation in an air-silica microstructure optical fiber,” Opt. Lett.26(9), 608–610 (2001). [CrossRef] [PubMed]
- P. Falk, M. H. Frosz, O. Bang, L. Thrane, P. E. Andersen, A. O. Bjarklev, K. P. Hansen, and J. Broeng, “Broadband light generation at approximately 1300 nm through spectrally recoiled solitons and dispersive waves,” Opt. Lett.33(6), 621–623 (2008). [CrossRef] [PubMed]
- H. N. Paulsen, K. M. Hilligsøe, J. Thøgersen, S. R. Keiding, and J. J. Larsen, “Coherent anti-Stokes Raman scattering microscopy with a photonic crystal fiber based light source,” Opt. Lett.28(13), 1123–1125 (2003). [CrossRef] [PubMed]
- A. F. Pegoraro, A. Ridsdale, D. J. Moffatt, J. P. Pezacki, B. K. Thomas, L. Fu, L. Dong, M. E. Fermann, and A. Stolow, “All-fiber CARS microscopy of live cells,” Opt. Express17(23), 20700–20706 (2009). [CrossRef] [PubMed]
- J. X. Cheng, L. D. Book, and X. S. Xie, “Polarization coherent anti-Stokes Raman scattering microscopy,” Opt. Lett.26(17), 1341–1343 (2001). [CrossRef] [PubMed]
- F. Lu, W. Zheng, and Z. Huang, “Phase-controlled polarization coherent anti-Stokes Raman scattering microscopy for high-sensitivity and high-contrast molecular imaging,” J. Opt. Soc. Am. B25(11), 1907–1913 (2008). [CrossRef]
- N. K. T. Photonics, femtoWHITE CARS: http://www.nktphotonics.com/files/files/FWCARS-090612.pdf .
- J. C. Knight, T. A. Birks, P. S. J. Russell, and D. M. Atkin, “All-silica single-mode optical fiber with photonic crystal cladding,” Opt. Lett.21(19), 1547–1549 (1996). [CrossRef] [PubMed]
- A. Ortigosa-Blanch, J. C. Knight, W. J. Wadsworth, J. Arriaga, B. J. Mangan, T. A. Birks, and P. St. J. Russell, “Highly birefringent photonic crystal fibers,” Opt. Lett.25(18), 1325–1327 (2000). [CrossRef] [PubMed]
- S. Diddams and J. C. Diels, “Dispersion measurements with white-light interferometry,” J. Opt. Soc. Am. B13(6), 1120 (1996). [CrossRef]
- S. Johnson and J. Joannopoulos, “Block-iterative frequency-domain methods for Maxwell’s equations in a planewave basis,” Opt. Express8(3), 173–190 (2001). [CrossRef] [PubMed]
- M. H. Frosz, P. Falk, and O. Bang, “The role of the second zero-dispersion wavelength in generation of supercontinua and bright-bright soliton-pairs across the zero-dispersion wavelength,” Opt. Express13(16), 6181–6192 (2005). [CrossRef] [PubMed]
- K. L. Corwin, N. R. Newbury, J. M. Dudley, S. Coen, S. A. Diddams, K. Weber, and R. S. Windeler, “Fundamental noise limitations to supercontinuum generation in microstructure fiber,” Phys. Rev. Lett.90(11), 113904 (2003). [CrossRef] [PubMed]
- K. L. Corwin, N. R. Newbury, J. M. Dudley, S. Coen, S. A. Diddams, B. R. Washburn, K. Weber, and R. S. Windeler, “Fundamental amplitude noise limitations to supercontinuum spectra generated in a microstructure fiber,” Appl. Phys. B77(2-3), 269–277 (2003). [CrossRef]
- G. Keiser, Optical Fiber Communications, 2nd ed. (McGraw-Hill Science, 1991).
- T. P. White, R. C. McPhedran, C. M. de Sterke, L. C. Botten, and M. J. Steel, “Confinement losses in microstructured optical fibers,” Opt. Lett.26(21), 1660–1662 (2001). [CrossRef] [PubMed]
- A. F. Pegoraro, A. Ridsdale, D. J. Moffatt, Y. Jia, J. P. Pezacki, and A. Stolow, “Optimally chirped multimodal CARS microscopy based on a single Ti:sapphire oscillator,” Opt. Express17(4), 2984–2996 (2009). [CrossRef] [PubMed]
- P. Falk, M. H. Frosz, O. Bang, L. Thrane, P. E. Andersen, A. O. Bjarklev, K. P. Hansen, and J. Broeng, “Broadband light generation at approximately 1300 nm through spectrally recoiled solitons and dispersive waves,” Opt. Lett.33(6), 621–623 (2008). [CrossRef] [PubMed]
- M. H. Frosz, P. Falk, and O. Bang, “The role of the second zero-dispersion wavelength in generation of supercontinua and bright-bright soliton-pairs across the zero-dispersion wavelength,” Opt. Express13(16), 6181–6192 (2005). [CrossRef] [PubMed]
- R. S. Lim, A. Kratzer, N. P. Barry, S. Miyazaki-Anzai, M. Miyazaki, W. W. Mantulin, M. Levi, E. O. Potma, and B. J. Tromberg, “Multimodal CARS microscopy determination of the impact of diet on macrophage infiltration and lipid accumulation on plaque formation in ApoE-deficient mice,” J. Lipid Res.51(7), 1729–1737 (2010). [CrossRef] [PubMed]
- R. F. Begley, A. B. Harvey, and R. L. Byer, “Coherent anti-Stokes Raman spectroscopy,” Appl. Phys. Lett.25(7), 387–390 (1974). [CrossRef]
- A. Ortigosa-Blanch, J. C. Knight, W. J. Wadsworth, J. Arriaga, B. J. Mangan, T. A. Birks, and P. St. J. Russell, “Highly birefringent photonic crystal fibers,” Opt. Lett.25(18), 1325–1327 (2000). [CrossRef] [PubMed]
- J. C. Knight, T. A. Birks, P. S. J. Russell, and D. M. Atkin, “All-silica single-mode optical fiber with photonic crystal cladding,” Opt. Lett.21(19), 1547–1549 (1996). [CrossRef] [PubMed]
- R. K. Lyn, D. C. Kennedy, S. M. Sagan, D. R. Blais, Y. Rouleau, A. F. Pegoraro, X. S. Xie, A. Stolow, and J. P. Pezacki, “Direct imaging of the disruption of hepatitis C virus replication complexes by inhibitors of lipid metabolism,” Virology394(1), 130–142 (2009). [CrossRef] [PubMed]
- R. F. Begley, A. B. Harvey, and R. L. Byer, “Coherent anti-Stokes Raman spectroscopy,” Appl. Phys. Lett.25(7), 387–390 (1974). [CrossRef]
- Y. Zeng, B. Saar, M. Friedrich, F. Chen, Y.-S. Liu, R. Dixon, M. Himmel, X. Xie, and S.-Y. Ding, “Imaging lignin-downregulated alfalfa using coherent anti-Stokes Raman scattering microscopy,” BioEnergy Res.3(3), 272–277 (2010). [CrossRef]
- J. Imitola, D. Côté, S. Rasmussen, X. S. Xie, Y. Liu, T. Chitnis, R. L. Sidman, C. P. Lin, and S. J. Khoury, “Multimodal coherent anti-Stokes Raman scattering microscopy reveals microglia-associated myelin and axonal dysfunction in multiple sclerosis-like lesions in mice,” J. Biomed. Opt.16(2), 021109 (2011). [CrossRef] [PubMed]
- K. L. Corwin, N. R. Newbury, J. M. Dudley, S. Coen, S. A. Diddams, K. Weber, and R. S. Windeler, “Fundamental noise limitations to supercontinuum generation in microstructure fiber,” Phys. Rev. Lett.90(11), 113904 (2003). [CrossRef] [PubMed]
- K. L. Corwin, N. R. Newbury, J. M. Dudley, S. Coen, S. A. Diddams, B. R. Washburn, K. Weber, and R. S. Windeler, “Fundamental amplitude noise limitations to supercontinuum spectra generated in a microstructure fiber,” Appl. Phys. B77(2-3), 269–277 (2003). [CrossRef]
- K. L. Corwin, N. R. Newbury, J. M. Dudley, S. Coen, S. A. Diddams, B. R. Washburn, K. Weber, and R. S. Windeler, “Fundamental amplitude noise limitations to supercontinuum spectra generated in a microstructure fiber,” Appl. Phys. B77(2-3), 269–277 (2003). [CrossRef]
- K. L. Corwin, N. R. Newbury, J. M. Dudley, S. Coen, S. A. Diddams, K. Weber, and R. S. Windeler, “Fundamental noise limitations to supercontinuum generation in microstructure fiber,” Phys. Rev. Lett.90(11), 113904 (2003). [CrossRef] [PubMed]
- J. Imitola, D. Côté, S. Rasmussen, X. S. Xie, Y. Liu, T. Chitnis, R. L. Sidman, C. P. Lin, and S. J. Khoury, “Multimodal coherent anti-Stokes Raman scattering microscopy reveals microglia-associated myelin and axonal dysfunction in multiple sclerosis-like lesions in mice,” J. Biomed. Opt.16(2), 021109 (2011). [CrossRef] [PubMed]
- K. L. Corwin, N. R. Newbury, J. M. Dudley, S. Coen, S. A. Diddams, K. Weber, and R. S. Windeler, “Fundamental noise limitations to supercontinuum generation in microstructure fiber,” Phys. Rev. Lett.90(11), 113904 (2003). [CrossRef] [PubMed]
- K. L. Corwin, N. R. Newbury, J. M. Dudley, S. Coen, S. A. Diddams, B. R. Washburn, K. Weber, and R. S. Windeler, “Fundamental amplitude noise limitations to supercontinuum spectra generated in a microstructure fiber,” Appl. Phys. B77(2-3), 269–277 (2003). [CrossRef]
- Y. Zeng, B. Saar, M. Friedrich, F. Chen, Y.-S. Liu, R. Dixon, M. Himmel, X. Xie, and S.-Y. Ding, “Imaging lignin-downregulated alfalfa using coherent anti-Stokes Raman scattering microscopy,” BioEnergy Res.3(3), 272–277 (2010). [CrossRef]
- Y. Zeng, B. Saar, M. Friedrich, F. Chen, Y.-S. Liu, R. Dixon, M. Himmel, X. Xie, and S.-Y. Ding, “Imaging lignin-downregulated alfalfa using coherent anti-Stokes Raman scattering microscopy,” BioEnergy Res.3(3), 272–277 (2010). [CrossRef]
- K. L. Corwin, N. R. Newbury, J. M. Dudley, S. Coen, S. A. Diddams, K. Weber, and R. S. Windeler, “Fundamental noise limitations to supercontinuum generation in microstructure fiber,” Phys. Rev. Lett.90(11), 113904 (2003). [CrossRef] [PubMed]
- K. L. Corwin, N. R. Newbury, J. M. Dudley, S. Coen, S. A. Diddams, B. R. Washburn, K. Weber, and R. S. Windeler, “Fundamental amplitude noise limitations to supercontinuum spectra generated in a microstructure fiber,” Appl. Phys. B77(2-3), 269–277 (2003). [CrossRef]
- P. Falk, M. H. Frosz, O. Bang, L. Thrane, P. E. Andersen, A. O. Bjarklev, K. P. Hansen, and J. Broeng, “Broadband light generation at approximately 1300 nm through spectrally recoiled solitons and dispersive waves,” Opt. Lett.33(6), 621–623 (2008). [CrossRef] [PubMed]
- M. H. Frosz, P. Falk, and O. Bang, “The role of the second zero-dispersion wavelength in generation of supercontinua and bright-bright soliton-pairs across the zero-dispersion wavelength,” Opt. Express13(16), 6181–6192 (2005). [CrossRef] [PubMed]
- Y. Zeng, B. Saar, M. Friedrich, F. Chen, Y.-S. Liu, R. Dixon, M. Himmel, X. Xie, and S.-Y. Ding, “Imaging lignin-downregulated alfalfa using coherent anti-Stokes Raman scattering microscopy,” BioEnergy Res.3(3), 272–277 (2010). [CrossRef]
- P. Falk, M. H. Frosz, O. Bang, L. Thrane, P. E. Andersen, A. O. Bjarklev, K. P. Hansen, and J. Broeng, “Broadband light generation at approximately 1300 nm through spectrally recoiled solitons and dispersive waves,” Opt. Lett.33(6), 621–623 (2008). [CrossRef] [PubMed]
- M. H. Frosz, P. Falk, and O. Bang, “The role of the second zero-dispersion wavelength in generation of supercontinua and bright-bright soliton-pairs across the zero-dispersion wavelength,” Opt. Express13(16), 6181–6192 (2005). [CrossRef] [PubMed]
- R. F. Begley, A. B. Harvey, and R. L. Byer, “Coherent anti-Stokes Raman spectroscopy,” Appl. Phys. Lett.25(7), 387–390 (1974). [CrossRef]
- A. C. T. Ko, A. Ridsdale, M. S. D. Smith, L. B. Mostaco-Guidolin, M. D. Hewko, A. F. Pegoraro, E. K. Kohlenberg, B. Schattka, M. Shiomi, A. Stolow, and M. G. Sowa, “Multimodal nonlinear optical imaging of atherosclerotic plaque development in myocardial infarction-prone rabbits,” J. Biomed. Opt.15(2), 020501 (2010). [CrossRef] [PubMed]
- K. M. Hilligsøe, T. Andersen, H. Paulsen, C. Nielsen, K. Mølmer, S. Keiding, R. Kristiansen, K. Hansen, and J. Larsen, “Supercontinuum generation in a photonic crystal fiber with two zero dispersion wavelengths,” Opt. Express12(6), 1045–1054 (2004). [CrossRef] [PubMed]
- H. N. Paulsen, K. M. Hilligsøe, J. Thøgersen, S. R. Keiding, and J. J. Larsen, “Coherent anti-Stokes Raman scattering microscopy with a photonic crystal fiber based light source,” Opt. Lett.28(13), 1123–1125 (2003). [CrossRef] [PubMed]
- Y. Zeng, B. Saar, M. Friedrich, F. Chen, Y.-S. Liu, R. Dixon, M. Himmel, X. Xie, and S.-Y. Ding, “Imaging lignin-downregulated alfalfa using coherent anti-Stokes Raman scattering microscopy,” BioEnergy Res.3(3), 272–277 (2010). [CrossRef]
- J. Imitola, D. Côté, S. Rasmussen, X. S. Xie, Y. Liu, T. Chitnis, R. L. Sidman, C. P. Lin, and S. J. Khoury, “Multimodal coherent anti-Stokes Raman scattering microscopy reveals microglia-associated myelin and axonal dysfunction in multiple sclerosis-like lesions in mice,” J. Biomed. Opt.16(2), 021109 (2011). [CrossRef] [PubMed]
- R. K. Lyn, D. C. Kennedy, S. M. Sagan, D. R. Blais, Y. Rouleau, A. F. Pegoraro, X. S. Xie, A. Stolow, and J. P. Pezacki, “Direct imaging of the disruption of hepatitis C virus replication complexes by inhibitors of lipid metabolism,” Virology394(1), 130–142 (2009). [CrossRef] [PubMed]
- J. Imitola, D. Côté, S. Rasmussen, X. S. Xie, Y. Liu, T. Chitnis, R. L. Sidman, C. P. Lin, and S. J. Khoury, “Multimodal coherent anti-Stokes Raman scattering microscopy reveals microglia-associated myelin and axonal dysfunction in multiple sclerosis-like lesions in mice,” J. Biomed. Opt.16(2), 021109 (2011). [CrossRef] [PubMed]
- A. Ortigosa-Blanch, J. C. Knight, W. J. Wadsworth, J. Arriaga, B. J. Mangan, T. A. Birks, and P. St. J. Russell, “Highly birefringent photonic crystal fibers,” Opt. Lett.25(18), 1325–1327 (2000). [CrossRef] [PubMed]
- J. C. Knight, T. A. Birks, P. S. J. Russell, and D. M. Atkin, “All-silica single-mode optical fiber with photonic crystal cladding,” Opt. Lett.21(19), 1547–1549 (1996). [CrossRef] [PubMed]
- A. C. T. Ko, A. Ridsdale, M. S. D. Smith, L. B. Mostaco-Guidolin, M. D. Hewko, A. F. Pegoraro, E. K. Kohlenberg, B. Schattka, M. Shiomi, A. Stolow, and M. G. Sowa, “Multimodal nonlinear optical imaging of atherosclerotic plaque development in myocardial infarction-prone rabbits,” J. Biomed. Opt.15(2), 020501 (2010). [CrossRef] [PubMed]
- A. C. T. Ko, A. Ridsdale, M. S. D. Smith, L. B. Mostaco-Guidolin, M. D. Hewko, A. F. Pegoraro, E. K. Kohlenberg, B. Schattka, M. Shiomi, A. Stolow, and M. G. Sowa, “Multimodal nonlinear optical imaging of atherosclerotic plaque development in myocardial infarction-prone rabbits,” J. Biomed. Opt.15(2), 020501 (2010). [CrossRef] [PubMed]
- R. S. Lim, A. Kratzer, N. P. Barry, S. Miyazaki-Anzai, M. Miyazaki, W. W. Mantulin, M. Levi, E. O. Potma, and B. J. Tromberg, “Multimodal CARS microscopy determination of the impact of diet on macrophage infiltration and lipid accumulation on plaque formation in ApoE-deficient mice,” J. Lipid Res.51(7), 1729–1737 (2010). [CrossRef] [PubMed]
- R. S. Lim, A. Kratzer, N. P. Barry, S. Miyazaki-Anzai, M. Miyazaki, W. W. Mantulin, M. Levi, E. O. Potma, and B. J. Tromberg, “Multimodal CARS microscopy determination of the impact of diet on macrophage infiltration and lipid accumulation on plaque formation in ApoE-deficient mice,” J. Lipid Res.51(7), 1729–1737 (2010). [CrossRef] [PubMed]
- R. S. Lim, A. Kratzer, N. P. Barry, S. Miyazaki-Anzai, M. Miyazaki, W. W. Mantulin, M. Levi, E. O. Potma, and B. J. Tromberg, “Multimodal CARS microscopy determination of the impact of diet on macrophage infiltration and lipid accumulation on plaque formation in ApoE-deficient mice,” J. Lipid Res.51(7), 1729–1737 (2010). [CrossRef] [PubMed]
- J. Imitola, D. Côté, S. Rasmussen, X. S. Xie, Y. Liu, T. Chitnis, R. L. Sidman, C. P. Lin, and S. J. Khoury, “Multimodal coherent anti-Stokes Raman scattering microscopy reveals microglia-associated myelin and axonal dysfunction in multiple sclerosis-like lesions in mice,” J. Biomed. Opt.16(2), 021109 (2011). [CrossRef] [PubMed]
- J. Imitola, D. Côté, S. Rasmussen, X. S. Xie, Y. Liu, T. Chitnis, R. L. Sidman, C. P. Lin, and S. J. Khoury, “Multimodal coherent anti-Stokes Raman scattering microscopy reveals microglia-associated myelin and axonal dysfunction in multiple sclerosis-like lesions in mice,” J. Biomed. Opt.16(2), 021109 (2011). [CrossRef] [PubMed]
- Y. Zeng, B. Saar, M. Friedrich, F. Chen, Y.-S. Liu, R. Dixon, M. Himmel, X. Xie, and S.-Y. Ding, “Imaging lignin-downregulated alfalfa using coherent anti-Stokes Raman scattering microscopy,” BioEnergy Res.3(3), 272–277 (2010). [CrossRef]
- R. K. Lyn, D. C. Kennedy, S. M. Sagan, D. R. Blais, Y. Rouleau, A. F. Pegoraro, X. S. Xie, A. Stolow, and J. P. Pezacki, “Direct imaging of the disruption of hepatitis C virus replication complexes by inhibitors of lipid metabolism,” Virology394(1), 130–142 (2009). [CrossRef] [PubMed]
- R. S. Lim, A. Kratzer, N. P. Barry, S. Miyazaki-Anzai, M. Miyazaki, W. W. Mantulin, M. Levi, E. O. Potma, and B. J. Tromberg, “Multimodal CARS microscopy determination of the impact of diet on macrophage infiltration and lipid accumulation on plaque formation in ApoE-deficient mice,” J. Lipid Res.51(7), 1729–1737 (2010). [CrossRef] [PubMed]
- R. S. Lim, A. Kratzer, N. P. Barry, S. Miyazaki-Anzai, M. Miyazaki, W. W. Mantulin, M. Levi, E. O. Potma, and B. J. Tromberg, “Multimodal CARS microscopy determination of the impact of diet on macrophage infiltration and lipid accumulation on plaque formation in ApoE-deficient mice,” J. Lipid Res.51(7), 1729–1737 (2010). [CrossRef] [PubMed]
- R. S. Lim, A. Kratzer, N. P. Barry, S. Miyazaki-Anzai, M. Miyazaki, W. W. Mantulin, M. Levi, E. O. Potma, and B. J. Tromberg, “Multimodal CARS microscopy determination of the impact of diet on macrophage infiltration and lipid accumulation on plaque formation in ApoE-deficient mice,” J. Lipid Res.51(7), 1729–1737 (2010). [CrossRef] [PubMed]
- A. F. Pegoraro, A. Ridsdale, D. J. Moffatt, J. P. Pezacki, B. K. Thomas, L. Fu, L. Dong, M. E. Fermann, and A. Stolow, “All-fiber CARS microscopy of live cells,” Opt. Express17(23), 20700–20706 (2009). [CrossRef] [PubMed]
- A. F. Pegoraro, A. Ridsdale, D. J. Moffatt, Y. Jia, J. P. Pezacki, and A. Stolow, “Optimally chirped multimodal CARS microscopy based on a single Ti:sapphire oscillator,” Opt. Express17(4), 2984–2996 (2009). [CrossRef] [PubMed]
- A. C. T. Ko, A. Ridsdale, M. S. D. Smith, L. B. Mostaco-Guidolin, M. D. Hewko, A. F. Pegoraro, E. K. Kohlenberg, B. Schattka, M. Shiomi, A. Stolow, and M. G. Sowa, “Multimodal nonlinear optical imaging of atherosclerotic plaque development in myocardial infarction-prone rabbits,” J. Biomed. Opt.15(2), 020501 (2010). [CrossRef] [PubMed]
- X. Nan, A. M. Tonary, A. Stolow, X. S. Xie, and J. P. Pezacki, “Intracellular imaging of HCV RNA and cellular lipids by using simultaneous two-photon fluorescence and coherent anti-Stokes Raman scattering microscopies,” ChemBioChem7(12), 1895–1897 (2006). [CrossRef] [PubMed]
- K. L. Corwin, N. R. Newbury, J. M. Dudley, S. Coen, S. A. Diddams, K. Weber, and R. S. Windeler, “Fundamental noise limitations to supercontinuum generation in microstructure fiber,” Phys. Rev. Lett.90(11), 113904 (2003). [CrossRef] [PubMed]
- K. L. Corwin, N. R. Newbury, J. M. Dudley, S. Coen, S. A. Diddams, B. R. Washburn, K. Weber, and R. S. Windeler, “Fundamental amplitude noise limitations to supercontinuum spectra generated in a microstructure fiber,” Appl. Phys. B77(2-3), 269–277 (2003). [CrossRef]
- A. C. T. Ko, A. Ridsdale, M. S. D. Smith, L. B. Mostaco-Guidolin, M. D. Hewko, A. F. Pegoraro, E. K. Kohlenberg, B. Schattka, M. Shiomi, A. Stolow, and M. G. Sowa, “Multimodal nonlinear optical imaging of atherosclerotic plaque development in myocardial infarction-prone rabbits,” J. Biomed. Opt.15(2), 020501 (2010). [CrossRef] [PubMed]
- R. K. Lyn, D. C. Kennedy, S. M. Sagan, D. R. Blais, Y. Rouleau, A. F. Pegoraro, X. S. Xie, A. Stolow, and J. P. Pezacki, “Direct imaging of the disruption of hepatitis C virus replication complexes by inhibitors of lipid metabolism,” Virology394(1), 130–142 (2009). [CrossRef] [PubMed]
- A. F. Pegoraro, A. Ridsdale, D. J. Moffatt, J. P. Pezacki, B. K. Thomas, L. Fu, L. Dong, M. E. Fermann, and A. Stolow, “All-fiber CARS microscopy of live cells,” Opt. Express17(23), 20700–20706 (2009). [CrossRef] [PubMed]
- A. F. Pegoraro, A. Ridsdale, D. J. Moffatt, Y. Jia, J. P. Pezacki, and A. Stolow, “Optimally chirped multimodal CARS microscopy based on a single Ti:sapphire oscillator,” Opt. Express17(4), 2984–2996 (2009). [CrossRef] [PubMed]
- A. F. Pegoraro, A. Ridsdale, D. J. Moffatt, Y. Jia, J. P. Pezacki, and A. Stolow, “Optimally chirped multimodal CARS microscopy based on a single Ti:sapphire oscillator,” Opt. Express17(4), 2984–2996 (2009). [CrossRef] [PubMed]
- A. F. Pegoraro, A. Ridsdale, D. J. Moffatt, J. P. Pezacki, B. K. Thomas, L. Fu, L. Dong, M. E. Fermann, and A. Stolow, “All-fiber CARS microscopy of live cells,” Opt. Express17(23), 20700–20706 (2009). [CrossRef] [PubMed]
- R. K. Lyn, D. C. Kennedy, S. M. Sagan, D. R. Blais, Y. Rouleau, A. F. Pegoraro, X. S. Xie, A. Stolow, and J. P. Pezacki, “Direct imaging of the disruption of hepatitis C virus replication complexes by inhibitors of lipid metabolism,” Virology394(1), 130–142 (2009). [CrossRef] [PubMed]
- X. Nan, A. M. Tonary, A. Stolow, X. S. Xie, and J. P. Pezacki, “Intracellular imaging of HCV RNA and cellular lipids by using simultaneous two-photon fluorescence and coherent anti-Stokes Raman scattering microscopies,” ChemBioChem7(12), 1895–1897 (2006). [CrossRef] [PubMed]
- R. S. Lim, A. Kratzer, N. P. Barry, S. Miyazaki-Anzai, M. Miyazaki, W. W. Mantulin, M. Levi, E. O. Potma, and B. J. Tromberg, “Multimodal CARS microscopy determination of the impact of diet on macrophage infiltration and lipid accumulation on plaque formation in ApoE-deficient mice,” J. Lipid Res.51(7), 1729–1737 (2010). [CrossRef] [PubMed]
- I. Hartl, X. D. Li, C. Chudoba, R. K. Ghanta, T. H. Ko, J. G. Fujimoto, J. K. Ranka, and R. S. Windeler, “Ultrahigh-resolution optical coherence tomography using continuum generation in an air-silica microstructure optical fiber,” Opt. Lett.26(9), 608–610 (2001). [CrossRef] [PubMed]
- J. K. Ranka, R. S. Windeler, and A. J. Stentz, “Optical properties of high-delta air silica microstructure optical fibers,” Opt. Lett.25(11), 796–798 (2000). [CrossRef] [PubMed]
- J. Imitola, D. Côté, S. Rasmussen, X. S. Xie, Y. Liu, T. Chitnis, R. L. Sidman, C. P. Lin, and S. J. Khoury, “Multimodal coherent anti-Stokes Raman scattering microscopy reveals microglia-associated myelin and axonal dysfunction in multiple sclerosis-like lesions in mice,” J. Biomed. Opt.16(2), 021109 (2011). [CrossRef] [PubMed]
- A. C. T. Ko, A. Ridsdale, M. S. D. Smith, L. B. Mostaco-Guidolin, M. D. Hewko, A. F. Pegoraro, E. K. Kohlenberg, B. Schattka, M. Shiomi, A. Stolow, and M. G. Sowa, “Multimodal nonlinear optical imaging of atherosclerotic plaque development in myocardial infarction-prone rabbits,” J. Biomed. Opt.15(2), 020501 (2010). [CrossRef] [PubMed]
- A. F. Pegoraro, A. Ridsdale, D. J. Moffatt, J. P. Pezacki, B. K. Thomas, L. Fu, L. Dong, M. E. Fermann, and A. Stolow, “All-fiber CARS microscopy of live cells,” Opt. Express17(23), 20700–20706 (2009). [CrossRef] [PubMed]
- A. F. Pegoraro, A. Ridsdale, D. J. Moffatt, Y. Jia, J. P. Pezacki, and A. Stolow, “Optimally chirped multimodal CARS microscopy based on a single Ti:sapphire oscillator,” Opt. Express17(4), 2984–2996 (2009). [CrossRef] [PubMed]
- R. K. Lyn, D. C. Kennedy, S. M. Sagan, D. R. Blais, Y. Rouleau, A. F. Pegoraro, X. S. Xie, A. Stolow, and J. P. Pezacki, “Direct imaging of the disruption of hepatitis C virus replication complexes by inhibitors of lipid metabolism,” Virology394(1), 130–142 (2009). [CrossRef] [PubMed]
- P. Russell, “Photonic crystal fibers,” Science299(5605), 358–362 (2003). [CrossRef] [PubMed]
- Y. Zeng, B. Saar, M. Friedrich, F. Chen, Y.-S. Liu, R. Dixon, M. Himmel, X. Xie, and S.-Y. Ding, “Imaging lignin-downregulated alfalfa using coherent anti-Stokes Raman scattering microscopy,” BioEnergy Res.3(3), 272–277 (2010). [CrossRef]
- R. K. Lyn, D. C. Kennedy, S. M. Sagan, D. R. Blais, Y. Rouleau, A. F. Pegoraro, X. S. Xie, A. Stolow, and J. P. Pezacki, “Direct imaging of the disruption of hepatitis C virus replication complexes by inhibitors of lipid metabolism,” Virology394(1), 130–142 (2009). [CrossRef] [PubMed]
- A. C. T. Ko, A. Ridsdale, M. S. D. Smith, L. B. Mostaco-Guidolin, M. D. Hewko, A. F. Pegoraro, E. K. Kohlenberg, B. Schattka, M. Shiomi, A. Stolow, and M. G. Sowa, “Multimodal nonlinear optical imaging of atherosclerotic plaque development in myocardial infarction-prone rabbits,” J. Biomed. Opt.15(2), 020501 (2010). [CrossRef] [PubMed]
- A. C. T. Ko, A. Ridsdale, M. S. D. Smith, L. B. Mostaco-Guidolin, M. D. Hewko, A. F. Pegoraro, E. K. Kohlenberg, B. Schattka, M. Shiomi, A. Stolow, and M. G. Sowa, “Multimodal nonlinear optical imaging of atherosclerotic plaque development in myocardial infarction-prone rabbits,” J. Biomed. Opt.15(2), 020501 (2010). [CrossRef] [PubMed]
- J. Imitola, D. Côté, S. Rasmussen, X. S. Xie, Y. Liu, T. Chitnis, R. L. Sidman, C. P. Lin, and S. J. Khoury, “Multimodal coherent anti-Stokes Raman scattering microscopy reveals microglia-associated myelin and axonal dysfunction in multiple sclerosis-like lesions in mice,” J. Biomed. Opt.16(2), 021109 (2011). [CrossRef] [PubMed]
- A. C. T. Ko, A. Ridsdale, M. S. D. Smith, L. B. Mostaco-Guidolin, M. D. Hewko, A. F. Pegoraro, E. K. Kohlenberg, B. Schattka, M. Shiomi, A. Stolow, and M. G. Sowa, “Multimodal nonlinear optical imaging of atherosclerotic plaque development in myocardial infarction-prone rabbits,” J. Biomed. Opt.15(2), 020501 (2010). [CrossRef] [PubMed]
- A. C. T. Ko, A. Ridsdale, M. S. D. Smith, L. B. Mostaco-Guidolin, M. D. Hewko, A. F. Pegoraro, E. K. Kohlenberg, B. Schattka, M. Shiomi, A. Stolow, and M. G. Sowa, “Multimodal nonlinear optical imaging of atherosclerotic plaque development in myocardial infarction-prone rabbits,” J. Biomed. Opt.15(2), 020501 (2010). [CrossRef] [PubMed]
- A. C. T. Ko, A. Ridsdale, M. S. D. Smith, L. B. Mostaco-Guidolin, M. D. Hewko, A. F. Pegoraro, E. K. Kohlenberg, B. Schattka, M. Shiomi, A. Stolow, and M. G. Sowa, “Multimodal nonlinear optical imaging of atherosclerotic plaque development in myocardial infarction-prone rabbits,” J. Biomed. Opt.15(2), 020501 (2010). [CrossRef] [PubMed]
- R. K. Lyn, D. C. Kennedy, S. M. Sagan, D. R. Blais, Y. Rouleau, A. F. Pegoraro, X. S. Xie, A. Stolow, and J. P. Pezacki, “Direct imaging of the disruption of hepatitis C virus replication complexes by inhibitors of lipid metabolism,” Virology394(1), 130–142 (2009). [CrossRef] [PubMed]
- A. F. Pegoraro, A. Ridsdale, D. J. Moffatt, J. P. Pezacki, B. K. Thomas, L. Fu, L. Dong, M. E. Fermann, and A. Stolow, “All-fiber CARS microscopy of live cells,” Opt. Express17(23), 20700–20706 (2009). [CrossRef] [PubMed]
- A. F. Pegoraro, A. Ridsdale, D. J. Moffatt, Y. Jia, J. P. Pezacki, and A. Stolow, “Optimally chirped multimodal CARS microscopy based on a single Ti:sapphire oscillator,” Opt. Express17(4), 2984–2996 (2009). [CrossRef] [PubMed]
- X. Nan, A. M. Tonary, A. Stolow, X. S. Xie, and J. P. Pezacki, “Intracellular imaging of HCV RNA and cellular lipids by using simultaneous two-photon fluorescence and coherent anti-Stokes Raman scattering microscopies,” ChemBioChem7(12), 1895–1897 (2006). [CrossRef] [PubMed]
- X. Nan, A. M. Tonary, A. Stolow, X. S. Xie, and J. P. Pezacki, “Intracellular imaging of HCV RNA and cellular lipids by using simultaneous two-photon fluorescence and coherent anti-Stokes Raman scattering microscopies,” ChemBioChem7(12), 1895–1897 (2006). [CrossRef] [PubMed]
- R. S. Lim, A. Kratzer, N. P. Barry, S. Miyazaki-Anzai, M. Miyazaki, W. W. Mantulin, M. Levi, E. O. Potma, and B. J. Tromberg, “Multimodal CARS microscopy determination of the impact of diet on macrophage infiltration and lipid accumulation on plaque formation in ApoE-deficient mice,” J. Lipid Res.51(7), 1729–1737 (2010). [CrossRef] [PubMed]
- K. L. Corwin, N. R. Newbury, J. M. Dudley, S. Coen, S. A. Diddams, B. R. Washburn, K. Weber, and R. S. Windeler, “Fundamental amplitude noise limitations to supercontinuum spectra generated in a microstructure fiber,” Appl. Phys. B77(2-3), 269–277 (2003). [CrossRef]
- K. L. Corwin, N. R. Newbury, J. M. Dudley, S. Coen, S. A. Diddams, B. R. Washburn, K. Weber, and R. S. Windeler, “Fundamental amplitude noise limitations to supercontinuum spectra generated in a microstructure fiber,” Appl. Phys. B77(2-3), 269–277 (2003). [CrossRef]
- K. L. Corwin, N. R. Newbury, J. M. Dudley, S. Coen, S. A. Diddams, K. Weber, and R. S. Windeler, “Fundamental noise limitations to supercontinuum generation in microstructure fiber,” Phys. Rev. Lett.90(11), 113904 (2003). [CrossRef] [PubMed]
- K. L. Corwin, N. R. Newbury, J. M. Dudley, S. Coen, S. A. Diddams, B. R. Washburn, K. Weber, and R. S. Windeler, “Fundamental amplitude noise limitations to supercontinuum spectra generated in a microstructure fiber,” Appl. Phys. B77(2-3), 269–277 (2003). [CrossRef]
- K. L. Corwin, N. R. Newbury, J. M. Dudley, S. Coen, S. A. Diddams, K. Weber, and R. S. Windeler, “Fundamental noise limitations to supercontinuum generation in microstructure fiber,” Phys. Rev. Lett.90(11), 113904 (2003). [CrossRef] [PubMed]
- I. Hartl, X. D. Li, C. Chudoba, R. K. Ghanta, T. H. Ko, J. G. Fujimoto, J. K. Ranka, and R. S. Windeler, “Ultrahigh-resolution optical coherence tomography using continuum generation in an air-silica microstructure optical fiber,” Opt. Lett.26(9), 608–610 (2001). [CrossRef] [PubMed]
- J. K. Ranka, R. S. Windeler, and A. J. Stentz, “Optical properties of high-delta air silica microstructure optical fibers,” Opt. Lett.25(11), 796–798 (2000). [CrossRef] [PubMed]
- Y. Zeng, B. Saar, M. Friedrich, F. Chen, Y.-S. Liu, R. Dixon, M. Himmel, X. Xie, and S.-Y. Ding, “Imaging lignin-downregulated alfalfa using coherent anti-Stokes Raman scattering microscopy,” BioEnergy Res.3(3), 272–277 (2010). [CrossRef]
- J. Imitola, D. Côté, S. Rasmussen, X. S. Xie, Y. Liu, T. Chitnis, R. L. Sidman, C. P. Lin, and S. J. Khoury, “Multimodal coherent anti-Stokes Raman scattering microscopy reveals microglia-associated myelin and axonal dysfunction in multiple sclerosis-like lesions in mice,” J. Biomed. Opt.16(2), 021109 (2011). [CrossRef] [PubMed]
- K. Wang, C. W. Freudiger, J. H. Lee, B. G. Saar, X. S. Xie, and C. Xu, “Synchronized time-lens source for coherent Raman scattering microscopy,” Opt. Express18(23), 24019–24024 (2010). [CrossRef] [PubMed]
- R. K. Lyn, D. C. Kennedy, S. M. Sagan, D. R. Blais, Y. Rouleau, A. F. Pegoraro, X. S. Xie, A. Stolow, and J. P. Pezacki, “Direct imaging of the disruption of hepatitis C virus replication complexes by inhibitors of lipid metabolism,” Virology394(1), 130–142 (2009). [CrossRef] [PubMed]
- X. Nan, A. M. Tonary, A. Stolow, X. S. Xie, and J. P. Pezacki, “Intracellular imaging of HCV RNA and cellular lipids by using simultaneous two-photon fluorescence and coherent anti-Stokes Raman scattering microscopies,” ChemBioChem7(12), 1895–1897 (2006). [CrossRef] [PubMed]
- J. X. Cheng, L. D. Book, and X. S. Xie, “Polarization coherent anti-Stokes Raman scattering microscopy,” Opt. Lett.26(17), 1341–1343 (2001). [CrossRef] [PubMed]
- Y. Zeng, B. Saar, M. Friedrich, F. Chen, Y.-S. Liu, R. Dixon, M. Himmel, X. Xie, and S.-Y. Ding, “Imaging lignin-downregulated alfalfa using coherent anti-Stokes Raman scattering microscopy,” BioEnergy Res.3(3), 272–277 (2010). [CrossRef]
Appl. Phys. B
- K. L. Corwin, N. R. Newbury, J. M. Dudley, S. Coen, S. A. Diddams, B. R. Washburn, K. Weber, and R. S. Windeler, “Fundamental amplitude noise limitations to supercontinuum spectra generated in a microstructure fiber,” Appl. Phys. B77(2-3), 269–277 (2003). [CrossRef]
Appl. Phys. Lett.
- R. F. Begley, A. B. Harvey, and R. L. Byer, “Coherent anti-Stokes Raman spectroscopy,” Appl. Phys. Lett.25(7), 387–390 (1974). [CrossRef]
BioEnergy Res.
- Y. Zeng, B. Saar, M. Friedrich, F. Chen, Y.-S. Liu, R. Dixon, M. Himmel, X. Xie, and S.-Y. Ding, “Imaging lignin-downregulated alfalfa using coherent anti-Stokes Raman scattering microscopy,” BioEnergy Res.3(3), 272–277 (2010). [CrossRef]
ChemBioChem
- X. Nan, A. M. Tonary, A. Stolow, X. S. Xie, and J. P. Pezacki, “Intracellular imaging of HCV RNA and cellular lipids by using simultaneous two-photon fluorescence and coherent anti-Stokes Raman scattering microscopies,” ChemBioChem7(12), 1895–1897 (2006). [CrossRef] [PubMed]
J. Biomed. Opt.
- J. Imitola, D. Côté, S. Rasmussen, X. S. Xie, Y. Liu, T. Chitnis, R. L. Sidman, C. P. Lin, and S. J. Khoury, “Multimodal coherent anti-Stokes Raman scattering microscopy reveals microglia-associated myelin and axonal dysfunction in multiple sclerosis-like lesions in mice,” J. Biomed. Opt.16(2), 021109 (2011). [CrossRef] [PubMed]
- A. C. T. Ko, A. Ridsdale, M. S. D. Smith, L. B. Mostaco-Guidolin, M. D. Hewko, A. F. Pegoraro, E. K. Kohlenberg, B. Schattka, M. Shiomi, A. Stolow, and M. G. Sowa, “Multimodal nonlinear optical imaging of atherosclerotic plaque development in myocardial infarction-prone rabbits,” J. Biomed. Opt.15(2), 020501 (2010). [CrossRef] [PubMed]
J. Lipid Res.
- R. S. Lim, A. Kratzer, N. P. Barry, S. Miyazaki-Anzai, M. Miyazaki, W. W. Mantulin, M. Levi, E. O. Potma, and B. J. Tromberg, “Multimodal CARS microscopy determination of the impact of diet on macrophage infiltration and lipid accumulation on plaque formation in ApoE-deficient mice,” J. Lipid Res.51(7), 1729–1737 (2010). [CrossRef] [PubMed]
J. Opt. Soc. Am. B
- F. Lu, W. Zheng, and Z. Huang, “Phase-controlled polarization coherent anti-Stokes Raman scattering microscopy for high-sensitivity and high-contrast molecular imaging,” J. Opt. Soc. Am. B25(11), 1907–1913 (2008). [CrossRef]
- S. Diddams and J. C. Diels, “Dispersion measurements with white-light interferometry,” J. Opt. Soc. Am. B13(6), 1120 (1996). [CrossRef]
Opt. Express
- S. Johnson and J. Joannopoulos, “Block-iterative frequency-domain methods for Maxwell’s equations in a planewave basis,” Opt. Express8(3), 173–190 (2001). [CrossRef] [PubMed]
- M. H. Frosz, P. Falk, and O. Bang, “The role of the second zero-dispersion wavelength in generation of supercontinua and bright-bright soliton-pairs across the zero-dispersion wavelength,” Opt. Express13(16), 6181–6192 (2005). [CrossRef] [PubMed]
- A. F. Pegoraro, A. Ridsdale, D. J. Moffatt, Y. Jia, J. P. Pezacki, and A. Stolow, “Optimally chirped multimodal CARS microscopy based on a single Ti:sapphire oscillator,” Opt. Express17(4), 2984–2996 (2009). [CrossRef] [PubMed]
- A. F. Pegoraro, A. Ridsdale, D. J. Moffatt, J. P. Pezacki, B. K. Thomas, L. Fu, L. Dong, M. E. Fermann, and A. Stolow, “All-fiber CARS microscopy of live cells,” Opt. Express17(23), 20700–20706 (2009). [CrossRef] [PubMed]
- K. M. Hilligsøe, T. Andersen, H. Paulsen, C. Nielsen, K. Mølmer, S. Keiding, R. Kristiansen, K. Hansen, and J. Larsen, “Supercontinuum generation in a photonic crystal fiber with two zero dispersion wavelengths,” Opt. Express12(6), 1045–1054 (2004). [CrossRef] [PubMed]
- K. Wang, C. W. Freudiger, J. H. Lee, B. G. Saar, X. S. Xie, and C. Xu, “Synchronized time-lens source for coherent Raman scattering microscopy,” Opt. Express18(23), 24019–24024 (2010). [CrossRef] [PubMed]
Opt. Lett.
- I. Hartl, X. D. Li, C. Chudoba, R. K. Ghanta, T. H. Ko, J. G. Fujimoto, J. K. Ranka, and R. S. Windeler, “Ultrahigh-resolution optical coherence tomography using continuum generation in an air-silica microstructure optical fiber,” Opt. Lett.26(9), 608–610 (2001). [CrossRef] [PubMed]
- P. Falk, M. H. Frosz, O. Bang, L. Thrane, P. E. Andersen, A. O. Bjarklev, K. P. Hansen, and J. Broeng, “Broadband light generation at approximately 1300 nm through spectrally recoiled solitons and dispersive waves,” Opt. Lett.33(6), 621–623 (2008). [CrossRef] [PubMed]
- H. N. Paulsen, K. M. Hilligsøe, J. Thøgersen, S. R. Keiding, and J. J. Larsen, “Coherent anti-Stokes Raman scattering microscopy with a photonic crystal fiber based light source,” Opt. Lett.28(13), 1123–1125 (2003). [CrossRef] [PubMed]
- J. X. Cheng, L. D. Book, and X. S. Xie, “Polarization coherent anti-Stokes Raman scattering microscopy,” Opt. Lett.26(17), 1341–1343 (2001). [CrossRef] [PubMed]
- J. K. Ranka, R. S. Windeler, and A. J. Stentz, “Optical properties of high-delta air silica microstructure optical fibers,” Opt. Lett.25(11), 796–798 (2000). [CrossRef] [PubMed]
- T. P. White, R. C. McPhedran, C. M. de Sterke, L. C. Botten, and M. J. Steel, “Confinement losses in microstructured optical fibers,” Opt. Lett.26(21), 1660–1662 (2001). [CrossRef] [PubMed]
- J. C. Knight, T. A. Birks, P. S. J. Russell, and D. M. Atkin, “All-silica single-mode optical fiber with photonic crystal cladding,” Opt. Lett.21(19), 1547–1549 (1996). [CrossRef] [PubMed]
- A. Ortigosa-Blanch, J. C. Knight, W. J. Wadsworth, J. Arriaga, B. J. Mangan, T. A. Birks, and P. St. J. Russell, “Highly birefringent photonic crystal fibers,” Opt. Lett.25(18), 1325–1327 (2000). [CrossRef] [PubMed]
Phys. Rev. Lett.
- K. L. Corwin, N. R. Newbury, J. M. Dudley, S. Coen, S. A. Diddams, K. Weber, and R. S. Windeler, “Fundamental noise limitations to supercontinuum generation in microstructure fiber,” Phys. Rev. Lett.90(11), 113904 (2003). [CrossRef] [PubMed]
Science
- P. Russell, “Photonic crystal fibers,” Science299(5605), 358–362 (2003). [CrossRef] [PubMed]
Virology
- R. K. Lyn, D. C. Kennedy, S. M. Sagan, D. R. Blais, Y. Rouleau, A. F. Pegoraro, X. S. Xie, A. Stolow, and J. P. Pezacki, “Direct imaging of the disruption of hepatitis C virus replication complexes by inhibitors of lipid metabolism,” Virology394(1), 130–142 (2009). [CrossRef] [PubMed]
Other
- G. Agrawal, Nonlinear Fiber Optics, 3rd ed. (Academics Press, 2001).
- N. K. T. Photonics, femtoWHITE CARS: http://www.nktphotonics.com/files/files/FWCARS-090612.pdf .
- G. Keiser, Optical Fiber Communications, 2nd ed. (McGraw-Hill Science, 1991).
2011, Imitola, J. Biomed. Opt.
- J. Imitola, D. Côté, S. Rasmussen, X. S. Xie, Y. Liu, T. Chitnis, R. L. Sidman, C. P. Lin, and S. J. Khoury, “Multimodal coherent anti-Stokes Raman scattering microscopy reveals microglia-associated myelin and axonal dysfunction in multiple sclerosis-like lesions in mice,” J. Biomed. Opt.16(2), 021109 (2011). [CrossRef] [PubMed]
- A. C. T. Ko, A. Ridsdale, M. S. D. Smith, L. B. Mostaco-Guidolin, M. D. Hewko, A. F. Pegoraro, E. K. Kohlenberg, B. Schattka, M. Shiomi, A. Stolow, and M. G. Sowa, “Multimodal nonlinear optical imaging of atherosclerotic plaque development in myocardial infarction-prone rabbits,” J. Biomed. Opt.15(2), 020501 (2010). [CrossRef] [PubMed]
- R. S. Lim, A. Kratzer, N. P. Barry, S. Miyazaki-Anzai, M. Miyazaki, W. W. Mantulin, M. Levi, E. O. Potma, and B. J. Tromberg, “Multimodal CARS microscopy determination of the impact of diet on macrophage infiltration and lipid accumulation on plaque formation in ApoE-deficient mice,” J. Lipid Res.51(7), 1729–1737 (2010). [CrossRef] [PubMed]
- Y. Zeng, B. Saar, M. Friedrich, F. Chen, Y.-S. Liu, R. Dixon, M. Himmel, X. Xie, and S.-Y. Ding, “Imaging lignin-downregulated alfalfa using coherent anti-Stokes Raman scattering microscopy,” BioEnergy Res.3(3), 272–277 (2010). [CrossRef]
- R. K. Lyn, D. C. Kennedy, S. M. Sagan, D. R. Blais, Y. Rouleau, A. F. Pegoraro, X. S. Xie, A. Stolow, and J. P. Pezacki, “Direct imaging of the disruption of hepatitis C virus replication complexes by inhibitors of lipid metabolism,” Virology394(1), 130–142 (2009). [CrossRef] [PubMed]
- X. Nan, A. M. Tonary, A. Stolow, X. S. Xie, and J. P. Pezacki, “Intracellular imaging of HCV RNA and cellular lipids by using simultaneous two-photon fluorescence and coherent anti-Stokes Raman scattering microscopies,” ChemBioChem7(12), 1895–1897 (2006). [CrossRef] [PubMed]
- P. Russell, “Photonic crystal fibers,” Science299(5605), 358–362 (2003). [CrossRef] [PubMed]
- K. L. Corwin, N. R. Newbury, J. M. Dudley, S. Coen, S. A. Diddams, K. Weber, and R. S. Windeler, “Fundamental noise limitations to supercontinuum generation in microstructure fiber,” Phys. Rev. Lett.90(11), 113904 (2003). [CrossRef] [PubMed]
- K. L. Corwin, N. R. Newbury, J. M. Dudley, S. Coen, S. A. Diddams, B. R. Washburn, K. Weber, and R. S. Windeler, “Fundamental amplitude noise limitations to supercontinuum spectra generated in a microstructure fiber,” Appl. Phys. B77(2-3), 269–277 (2003). [CrossRef]
- R. F. Begley, A. B. Harvey, and R. L. Byer, “Coherent anti-Stokes Raman spectroscopy,” Appl. Phys. Lett.25(7), 387–390 (1974). [CrossRef]
Cited By |
OSA is able to provide readers links to articles that cite this paper by participating in CrossRef's Cited-By Linking service. CrossRef includes content from more than 3000 publishers and societies. In addition to listing OSA journal articles that cite this paper, citing articles from other participating publishers will also be listed.
Related Journal Articles 
- Picosecond polarized supercontinuum generation controlled by intermodal four-wave mixing for fluorescence lifetime imaging microscopy (OE)
- Increasing the blue-shift of a supercontinuum by modifying the fiber glass composition (OE)
- Dispersion-modulation by high material loss in microstructured polymer optical fibers (OE)
- Second and third harmonics and flattened supercontinuum generation in tellurite microstructured fibers (OL)
- Zero-dispersion-wavelength-decreasing tellurite microstructured fiber for wide and flattened supercontinuum generation (OL)
Related Conference Papers 
- Resonant intra-channel four-wave mixing in strongly dispersion-managed transmission systems
- Estimation of the Hollow Core Photonic Crystal Fiber Nonlinearity Factor
- High Extinction Ratio Pulse Generation from FM Modulated Signal by Using Dispersion Imbalanced Fiber Loop Mirror
- Ultra-highly Pure 160 GHz Sub-picosecond Soliton Train Generation with Average Dispersion-managed Comb-like Dispersion Profiled Fiber Using Highly-nonlinear Fiber
- Sub-40-fs pulses with 18-W average power from a passively mode-locked thin disk Yb:YAG laser with nonlinear fiber compression
- Sub-40-fs pulses with 18-W average power from a passively mode-locked thin disk Yb:YAG laser with nonlinear fiber compression
- Firefox 11+
- Google Chrome 17+
- Internet Explorer 9+
- Safari 5+




OSA is a member of 