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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics


  • Editors: Andrew Dunn and Anthony Durkin
  • Vol. 7, Iss. 7 — Jun. 25, 2012

Visualizing breast cancer using the Twente photoacoustic mammoscope: What do we learn from twelve new patient measurements?

M. Heijblom, D. Piras, W. Xia, J.C.G. van Hespen, J.M. Klaase, F.M. van den Engh, T.G. van Leeuwen, W. Steenbergen, and S. Manohar  »View Author Affiliations

Optics Express, Vol. 20, Issue 11, pp. 11582-11597 (2012)

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We acquired images of breast malignancies using the Twente photoacoustic mammoscope (PAM), to obtain more information about the clinical feasibility and limitations of photoacoustic mammography. Results were compared with conventional imaging and histopathology. Ten technically acceptable measurements on patients with malignancies and two measurements on patients with cysts were performed. In the reconstructed volumes of all ten malignant lesions, a confined region with high contrast with respect to the background could be seen. In all malignant cases, the PA contrast of the abnormality was higher than the contrast on x-ray mammography. The PA contrast appeared to be independent of the mammographically estimated breast density and was absent in the case of cysts. Technological improvements to the instrument and further studies on less suspicious lesions are planned to further investigate the potential of PAM.

© 2012 OSA

OCIS Codes
(110.5120) Imaging systems : Photoacoustic imaging
(120.3890) Instrumentation, measurement, and metrology : Medical optics instrumentation
(170.1610) Medical optics and biotechnology : Clinical applications

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: January 18, 2012
Revised Manuscript: March 21, 2012
Manuscript Accepted: March 29, 2012
Published: May 7, 2012

Virtual Issues
Vol. 7, Iss. 7 Virtual Journal for Biomedical Optics

M. Heijblom, D. Piras, W. Xia, J.C.G. van Hespen, J.M. Klaase, F.M. van den Engh, T.G. van Leeuwen, W. Steenbergen, and S. Manohar, "Visualizing breast cancer using the Twente photoacoustic mammoscope: What do we learn from twelve new patient measurements?," Opt. Express 20, 11582-11597 (2012)

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