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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editors: Andrew Dunn and Anthony Durkin
  • Vol. 7, Iss. 7 — Jun. 25, 2012

Fiber-based source for multiplex-CARS microscopy based on degenerate four-wave mixing

Thomas Gottschall, Martin Baumgartl, Aude Sagnier, Jan Rothhardt, Cesar Jauregui, Jens Limpert, and Andreas Tünnermann  »View Author Affiliations


Optics Express, Vol. 20, Issue 11, pp. 12004-12013 (2012)
http://dx.doi.org/10.1364/OE.20.012004


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Abstract

We present a fiber-based laser source for multiplex coherent anti-Stokes Raman scattering (CARS) microscopy. This source is very compact and potentially alignment-free. The corresponding pump and Stokes pulses for the CARS process are generated by degenerate four-wave mixing (FWM) in photonic-crystal fibers. In addition, an ytterbium-doped fiber laser emitting spectrally narrow 100 ps pulses at 1035 nm wavelength serves as pump for the FWM frequency conversion. The FWM process delivers narrow-band pulses at 648 nm and drives a continuum-like spectrum ranging from 700 to 820 nm. With the presented source vibrational resonances with energies between 1200 cm−1 and 3200 cm−1 can be accessed with a resolution of 10 cm−1. Additionally, the temporal characteristics of the FWM output have been investigated by a cross-correlation setup, revealing the suitability of the emitted pulses for CARS microscopy. This work marks a significant step towards a simple and powerful all-fiber, maintenance-free multiplex-CARS source for real-world applications outside a laboratory environment.

© 2012 OSA

OCIS Codes
(060.4370) Fiber optics and optical communications : Nonlinear optics, fibers
(140.7300) Lasers and laser optics : Visible lasers
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(190.4370) Nonlinear optics : Nonlinear optics, fibers
(190.4380) Nonlinear optics : Nonlinear optics, four-wave mixing
(300.6230) Spectroscopy : Spectroscopy, coherent anti-Stokes Raman scattering
(180.4315) Microscopy : Nonlinear microscopy

ToC Category:
Microscopy

History
Original Manuscript: February 22, 2012
Revised Manuscript: April 3, 2012
Manuscript Accepted: April 8, 2012
Published: May 11, 2012

Virtual Issues
Vol. 7, Iss. 7 Virtual Journal for Biomedical Optics

Citation
Thomas Gottschall, Martin Baumgartl, Aude Sagnier, Jan Rothhardt, Cesar Jauregui, Jens Limpert, and Andreas Tünnermann, "Fiber-based source for multiplex-CARS microscopy based on degenerate four-wave mixing," Opt. Express 20, 12004-12013 (2012)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=oe-20-11-12004


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