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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editors: Andrew Dunn and Anthony Durkin
  • Vol. 7, Iss. 7 — Jun. 25, 2012

Inverse Monte Carlo for estimation of scattering and absorption in liquid optical phantoms

Hanna Karlsson, Ingemar Fredriksson, Marcus Larsson, and Tomas Strömberg  »View Author Affiliations


Optics Express, Vol. 20, Issue 11, pp. 12233-12246 (2012)
http://dx.doi.org/10.1364/OE.20.012233


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Abstract

A spectroscopic probe with multiple detecting fibers was used for quantifying absorption and scattering in liquid optical phantoms. The phantoms were mixtures of Intralipid and red and blue food dyes. Intensity calibration for the detecting fibers was undertaken using either a microsphere suspension (absolute calibration) or a uniform detector illumination (relative calibration between detectors). Two different scattering phase functions were used in an inverse Monte Carlo algorithm. Data were evaluated for residual spectra (systematic deviations and magnitude) and accuracy in estimation of scattering and absorption. Spectral fitting was improved by allowing for a 10% intensity relaxation in the optimization algorithm. For a multi-detector setup, non-systematic residual spectrum was only found using the more complex Gegenbauer-kernel phase function. However, the choice of phase function did not influence the accuracy in the estimation of absorption and scattering. Similar estimation accuracy as in the multi-detector setup was also obtained using either two relative calibrated detectors or one absolute calibrated detector at a fiber separation of 0.46 mm.

© 2012 OSA

OCIS Codes
(290.5820) Scattering : Scattering measurements
(290.7050) Scattering : Turbid media
(300.6550) Spectroscopy : Spectroscopy, visible
(170.6935) Medical optics and biotechnology : Tissue characterization

ToC Category:
Scattering

History
Original Manuscript: February 16, 2012
Revised Manuscript: April 6, 2012
Manuscript Accepted: April 6, 2012
Published: May 15, 2012

Virtual Issues
Vol. 7, Iss. 7 Virtual Journal for Biomedical Optics

Citation
Hanna Karlsson, Ingemar Fredriksson, Marcus Larsson, and Tomas Strömberg, "Inverse Monte Carlo for estimation of scattering and absorption in liquid optical phantoms," Opt. Express 20, 12233-12246 (2012)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=oe-20-11-12233


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