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CMOS image sensor integrated with micro-LED and multielectrode arrays for the patterned photostimulation and multichannel recording of neuronal tissueArata Nakajima, Hiroshi Kimura, Yosmongkol Sawadsaringkarn, Yasuyo Maezawa, Takuma Kobayashi, Toshihiko Noda, Kiyotaka Sasagawa, Takashi Tokuda, Yasuyuki Ishikawa, Sadao Shiosaka, and Jun Ohta »View Author Affiliations
Arata Nakajima,1
Hiroshi Kimura,1
Yosmongkol Sawadsaringkarn,1
Yasuyo Maezawa,1,3
Takuma Kobayashi,1,3
Toshihiko Noda,1,3
Kiyotaka Sasagawa,1,3
Takashi Tokuda,1,3
Yasuyuki Ishikawa,2,3
Sadao Shiosaka,2,3
and Jun Ohta1,3,*
1Graduate School of Materials Science, Nara Institute of Science and Technology, 8916-5 Takayama, Ikoma, Nara, 630-0192, Japan 2Graduate School of Biological Sciences, Nara Institute of Science and Technology, 8916-5 Takayama, Ikoma, Nara, 630-0192, Japan 3JST-CREST, 4-1-8 Honcho, Kawaguchi, Saitama 331-0012, Japan *Corresponding author: ohta@ms.naist.jp |
Optics Express, Vol. 20, Issue 6, pp. 6097-6108 (2012)
http://dx.doi.org/10.1364/OE.20.006097
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Abstract
We developed a complementary metal oxide semiconductor (CMOS) integrated device for optogenetic applications. This device can interface via neuronal tissue with three functional modalities: imaging, optical stimulation and electrical recording. The CMOS image sensor was fabricated on 0.35 μm standard CMOS process with built-in control circuits for an on-chip blue light-emitting diode (LED) array. The effective imaging area was 2.0 × 1.8 mm2. The pixel array was composed of 7.5 × 7.5 μm2 3-transistor active pixel sensors (APSs). The LED array had 10 × 8 micro-LEDs measuring 192 × 225 μm2. We integrated the device with a commercial multichannel recording system to make electrical recordings.
© 2012 OSA
OCIS Codes
(170.0170) Medical optics and biotechnology : Medical optics and biotechnology
(170.3880) Medical optics and biotechnology : Medical and biological imaging
ToC Category:
Medical Optics and Biotechnology
History
Original Manuscript: January 3, 2012
Revised Manuscript: February 7, 2012
Manuscript Accepted: February 9, 2012
Published: February 29, 2012
Virtual Issues
Vol. 7, Iss. 5 Virtual Journal for Biomedical Optics
Citation
Arata Nakajima, Hiroshi Kimura, Yosmongkol Sawadsaringkarn, Yasuyo Maezawa, Takuma Kobayashi, Toshihiko Noda, Kiyotaka Sasagawa, Takashi Tokuda, Yasuyuki Ishikawa, Sadao Shiosaka, and Jun Ohta, "CMOS image sensor integrated with micro-LED and multielectrode arrays for the patterned photostimulation and multichannel recording of neuronal tissue," Opt. Express 20, 6097-6108 (2012)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=oe-20-6-6097
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