OSA's Digital Library

Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editors: Andrew Dunn and Anthony Durkin
  • Vol. 7, Iss. 6 — May. 25, 2012

Optics InfoBase > Virtual Journal for Biomedical Optics > Volume 7 > Issue 6 > Page 8726

Evaluation of breast tumor margins in vivo with intraoperative photoacoustic imaging

Lei Xi, Stephen R. Grobmyer, Lei Wu, Ruimin Chen, Guangyin Zhou, Luke G. Gutwein, Jingjing Sun, Wenjun Liao, Qifa Zhou, Huikai Xie, and Huabei Jiang  »View Author Affiliations


Optics Express, Vol. 20, Issue 8, pp. 8726-8731 (2012)
http://dx.doi.org/10.1364/OE.20.008726


View Full Text Article

Enhanced HTML    Acrobat PDF (1022 KB) Open Access


Advanced Search

Browse Journals / Lookup Meetings

Browse by Journal and Year


   


Lookup Conference Papers

Close Browse Journals / Lookup Meetings

Article Tools

Share
Citations

Abstract

The use of photoacoustic effect is a promising approach for biomedical imaging in living tissues. Photoacoustic tomography (PAT) has been demonstrated to image breast cancer, brain vasculature, arthritis and seizure focus owing to its rich optical contrast and high resolution in a single imaging modality. Here we report a microelectromechanical systems (MEMS)-based intraoperative PAT (iPAT) technique, and demonstrate its ability to accurately map tumors in three-dimension and to inspect the completeness of tumor resection during surgery in a tumor-bearing mouse model. The MEMS imaging probe is small and has the potential to be conveniently used to guide surgical resection of tumors in the breast.

© 2012 OSA

OCIS Codes
(170.0110) Medical optics and biotechnology : Imaging systems
(170.5120) Medical optics and biotechnology : Photoacoustic imaging

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: February 13, 2012
Revised Manuscript: March 5, 2012
Manuscript Accepted: March 23, 2012
Published: March 30, 2012

Virtual Issues
Vol. 7, Iss. 6 Virtual Journal for Biomedical Optics

Citation
Lei Xi, Stephen R. Grobmyer, Lei Wu, Ruimin Chen, Guangyin Zhou, Luke G. Gutwein, Jingjing Sun, Wenjun Liao, Qifa Zhou, Huikai Xie, and Huabei Jiang, "Evaluation of breast tumor margins in vivo with intraoperative photoacoustic imaging," Opt. Express 20, 8726-8731 (2012)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=oe-20-8-8726


Sort:  Author  |  Year  |  Journal  |  Reset  

References

  1. A. Jemal, R. Siegel, E. Ward, Y. Hao, J. Xu, T. Murray, and M. J. Thun, “Cancer statistics, 2008,” CA Cancer J. Clin.58(2), 71–96 (2008). [CrossRef] [PubMed]
  2. American Cancer Society, Cancer facts and Figs. 2009 American cancer society, Atlanta, 2009.
  3. American Cancer Society, Cancer facts and Figs. 2010 American cancer society, Atlanta, 2010.
  4. A. Taghian, M. Mohiuddin, R. Jagsi, S. Goldberg, E. Ceilley, and S. Powell, “Current perceptions regarding surgical margin status after breast-conserving therapy: results of a survey,” Ann. Surg.241(4), 629–639 (2005). [CrossRef] [PubMed]
  5. L. Assersohn, T. J. Powles, S. Ashley, A. G. Nash, A. J. Neal, N. Sacks, J. Chang, U. Querci della Rovere, and N. Naziri, “Local relapse in primary breast cancer patients with unexcised positive surgical margins after lumpectomy, radiotherapy and chemoendocrine therapy,” Ann. Oncol.10(12), 1451–1455 (1999). [CrossRef] [PubMed]
  6. G. C. Balch, S. K. Mithani, J. F. Simpson, and M. C. Kelley, “Accuracy of intraoperative gross examination of surgical margin status in women undergoing partial mastectomy for breast malignancy,” Am. Surg.71(1), 22–27, discussion 27–28 (2005). [PubMed]
  7. B. Sigal-Zafrani, J. S. Lewis, K. B. Clough, A. Vincent-Salomon, A. Fourquet, M. Meunier, M. C. Falcou, X. Sastre-Garau, and Institut Curie Breast Study Group, “Histological margin assessment for breast ductal carcinoma in situ: precision and implications,” Mod. Pathol.17(1), 81–88 (2004). [CrossRef] [PubMed]
  8. F. Meric, N. Q. Mirza, G. Vlastos, T. A. Buchholz, H. M. Kuerer, G. V. Babiera, S. E. Singletary, M. I. Ross, F. C. Ames, B. W. Feig, S. Krishnamurthy, G. H. Perkins, M. D. McNeese, E. A. Strom, V. Valero, and K. K. Hunt, “Positive surgical margins and ipsilateral breast tumor recurrence predict disease-specific survival after breast-conserving therapy,” Cancer97(4), 926–933 (2003). [CrossRef] [PubMed]
  9. H. Jiang, Diffuse Optical Tomography: Principles and Applications (CRC Press, 2011).
  10. S. Manohar, A. Kharine, J. C. G. van Hespen, W. Steenbergen, and T. G. van Leeuwen, “Photoacoustic mammography laboratory prototype: imaging of breast tissue phantoms,” J. Biomed. Opt.9(6), 1172–1181 (2004). [CrossRef] [PubMed]
  11. L. V. Wang, “Multiscale photoacoustic microscopy and computed tomography,” Nat. Photonics3(9), 503–509 (2009). [CrossRef] [PubMed]
  12. A. A. Oraevsky, S. A. Ermilov, A. Conjusteau, T. Miller, R. R. Lacewell, K. Mehta, D. Herzog, S. Thompson, A. Stein, T. Khamapirad, M. McCorvey, and P. Otto, “Initial clinical evaluation of laser optoacoustic imaging system for diagnostic imaging of breast cancer,” Breast Cancer Res. Treat.106, S47 (2007).
  13. R. A. Kruger, K. D. Miller, H. E. Reynolds, W. L. Kiser, D. R. Reinecke, and G. A. Kruger, “Breast cancer in vivo: contrast enhancement with thermoacoustic CT at 434 MHz-feasibility study,” Radiology216(1), 279–283 (2000). [PubMed]
  14. C. Kim, K. H. Song, F. Gao, and L. V. Wang, “Sentinel lymph nodes and lymphatic vessels: noninvasive dual-modality in vivo mapping by using indocyanine green in rats--volumetric spectroscopic photoacoustic imaging and planar fluorescence imaging,” Radiology255(2), 442–450 (2010). [CrossRef] [PubMed]
  15. T. N. Erpelding, C. Kim, M. Pramanik, L. Jankovic, K. Maslov, Z. Guo, J. A. Margenthaler, M. D. Pashley, and L. V. Wang, “Sentinel lymph nodes in the rat: noninvasive photoacoustic and US imaging with a clinical US system,” Radiology256(1), 102–110 (2010). [CrossRef] [PubMed]
  16. Q. Zhou, X. Xu, E. Gottlieb, L. Sun, J. M. Cannata, H. Ameri, M. S. Humayun, P. Han, and K. K. Shung, “PMN-PT single crystal high frequency ultrasonic needle transducers for pulsed wave doppler application,” IEEE Trans. Ultrason., Ferroelec, Freq. Control54(3), 668–675 (2007).
  17. L. Wu and H. Xie, “A large vertical displacement electrothermal bimorph microactuator with very small lateral shift,” Sens. Actuators A Phys.145–146, 371–379 (2008). [CrossRef]
  18. J. M. Yang, K. Maslov, H. C. Yang, Q. Zhou, K. K. Shung, and L. V. Wang, “Photoacoustic endoscopy,” Opt. Lett.34(10), 1591–1593 (2009). [CrossRef] [PubMed]
  19. R. L. Shelton and B. E. Applegate, “Off-axis photoacoustic microscopy,” IEEE Trans. Biomed. Eng.57(8), 1835–1838 (2010). [CrossRef] [PubMed]

Cited By

 Alert me when this paper is cited

OSA is able to provide readers links to articles that cite this paper by participating in CrossRef's Cited-By Linking service. CrossRef includes content from more than 3000 publishers and societies. In addition to listing OSA journal articles that cite this paper, citing articles from other participating publishers will also be listed.

Figures

Fig. 1 Fig. 2 Fig. 3
 
Fig. 4 Fig. 5
 

Multimedia

Multimedia FilesRecommended Software
» Media 1: MOV (2889 KB)      QuickTime
» Media 2: MOV (738 KB)      QuickTime

« Previous Article  |  Next Article »

OSA is a member of CrossRef.

CrossCheck Deposited