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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editors: Andrew Dunn and Anthony Durkin
  • Vol. 7, Iss. 6 — May. 25, 2012

Evaluation of breast tumor margins in vivo with intraoperative photoacoustic imaging

Lei Xi, Stephen R. Grobmyer, Lei Wu, Ruimin Chen, Guangyin Zhou, Luke G. Gutwein, Jingjing Sun, Wenjun Liao, Qifa Zhou, Huikai Xie, and Huabei Jiang  »View Author Affiliations


Optics Express, Vol. 20, Issue 8, pp. 8726-8731 (2012)
http://dx.doi.org/10.1364/OE.20.008726


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Abstract

The use of photoacoustic effect is a promising approach for biomedical imaging in living tissues. Photoacoustic tomography (PAT) has been demonstrated to image breast cancer, brain vasculature, arthritis and seizure focus owing to its rich optical contrast and high resolution in a single imaging modality. Here we report a microelectromechanical systems (MEMS)-based intraoperative PAT (iPAT) technique, and demonstrate its ability to accurately map tumors in three-dimension and to inspect the completeness of tumor resection during surgery in a tumor-bearing mouse model. The MEMS imaging probe is small and has the potential to be conveniently used to guide surgical resection of tumors in the breast.

© 2012 OSA

OCIS Codes
(170.0110) Medical optics and biotechnology : Imaging systems
(170.5120) Medical optics and biotechnology : Photoacoustic imaging

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: February 13, 2012
Revised Manuscript: March 5, 2012
Manuscript Accepted: March 23, 2012
Published: March 30, 2012

Virtual Issues
Vol. 7, Iss. 6 Virtual Journal for Biomedical Optics

Citation
Lei Xi, Stephen R. Grobmyer, Lei Wu, Ruimin Chen, Guangyin Zhou, Luke G. Gutwein, Jingjing Sun, Wenjun Liao, Qifa Zhou, Huikai Xie, and Huabei Jiang, "Evaluation of breast tumor margins in vivo with intraoperative photoacoustic imaging," Opt. Express 20, 8726-8731 (2012)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=oe-20-8-8726


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