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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics


  • Editor: Gregory W. Faris
  • Vol. 1, Iss. 5 — May. 5, 2006

Highly sensitive detection of biomolecules with the magneto-optic surface-plasmon-resonance sensor

B. Sepúlveda, A. Calle, L. M. Lechuga, and G. Armelles  »View Author Affiliations

Optics Letters, Vol. 31, Issue 8, pp. 1085-1087 (2006)

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The characteristics of a novel magneto-optic surface-plasmon-resonance (MOSPR) sensor and its use for the detection of biomolecules are presented. This physical transduction principle is based on the combination of the magneto-optic activity of magnetic materials and a surface-plasmon resonance of metallic layers. Such a combination can produce a sharp enhancement of the magneto-optic effects that strongly depends on the optical properties of the surrounding medium, allowing its use for biosensing applications. Experimental characterizations of the MOSPR sensor have shown an increase in the limit of detection by a factor of 3 in changes of refractive index and in the adsorption of biomolecules compared with standard sensors. Optimization of the metallic layers and the experimental setup could result in an improvement of the limit of detection by as much as 1 order of magnitude.

© 2006 Optical Society of America

OCIS Codes
(130.6010) Integrated optics : Sensors
(230.0230) Optical devices : Optical devices

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: October 21, 2005
Revised Manuscript: January 12, 2006
Manuscript Accepted: January 18, 2006

Virtual Issues
Vol. 1, Iss. 5 Virtual Journal for Biomedical Optics

B. Sepúlveda, A. Calle, L. M. Lechuga, and G. Armelles, "Highly sensitive detection of biomolecules with the magneto-optic surface-plasmon-resonance sensor," Opt. Lett. 31, 1085-1087 (2006)

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  1. C. Nylander, B. Liedberg, and T. Lind, Sens. Actuators 3, 79 (1982). [CrossRef]
  2. B. Liedberg, C. Nylander, and I. Lundström, Sens. Actuators 4, 299 (1983). [CrossRef]
  3. J. Homola, S. S. Yee, and G. Gauglitz, Sens. Actuators B 54, 3 (1999). [CrossRef]
  4. A. A. Kolomenskii, P. D. Gershon, and H. A. Schuessler, Appl. Opt. 36, 6539 (1997). [CrossRef]
  5. T. Chinowsky, L. Jung, and S. Yee, Sens. Actuators B 54, 89 (1999). [CrossRef]
  6. L. M. Lechuga, in Biosensors and Modern Biospecific Analytical Techniques, L.Gorton, ed., Comprehensive Analytical Chemistry Series, XLIV (Elsevier, 2005), Chap. 5.
  7. S. Y. Wu, H. P. Ho, W. C. Law, C. Liu, and S. K. Kong, Opt. Lett. 29, 2378 (2004). [CrossRef] [PubMed]
  8. I. R. Hooper and J. R. Sambles, Appl. Phys. Lett. 85, 3017 (2004). [CrossRef]
  9. W. C. Kuo, C. Chou, and H. T. Wu, Opt. Lett. 28, 1329 (2003). [CrossRef] [PubMed]
  10. J. Guo, Z. Zhu, and W. Deng, Appl. Opt. 38, 6550 (1999). [CrossRef]
  11. B. Sepúlveda, G. Armelles, L. M. Lechuga, and A. Calle, 'Device and method for detecting changes in the refractive index of a dielectric medium,' Spain Patent Application P200401037-PCT/EP2005/006273 (June 11, 2004).
  12. P. E. Ferguson, O. M. Stafsudd, and R. F. Wallis, Physica B + C 89B, 91 (1977). [CrossRef]
  13. C. Hermann, V. A. Kosobukin, G. Lampel, J. Peretti, V. I. Safarov, and P. Bertrand, Phys. Rev. B 64, 235422 (2001). [CrossRef]
  14. J. H. Weaver, C. Krafka, D. W. Lynch, and E. E. Kock, in Physics Data: Optical Properties of Metals, H. Behrens, ed. (Fachinformationszentrum Karlsruhe, 1981), p. 45.

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