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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics


  • Editor: Gregory W. Faris
  • Vol. 2, Iss. 9 — Sep. 26, 2007

Imaging optically scattering objects with ultrasound-modulated optical tomography

Sri-Rajasekhar Kothapalli, Sava Sakadžić, Chulhong Kim, and Lihong V. Wang  »View Author Affiliations

Optics Letters, Vol. 32, Issue 16, pp. 2351-2353 (2007)

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We show the feasibility of imaging objects having different optical scattering coefficients relative to the surrounding scattering medium using ultrasound-modulated optical tomography (UOT). While the spatial resolution depends on ultrasound parameters, the image contrast depends on the difference in scattering coefficient between the object and the surrounding medium. Experimental measurements obtained with a CCD-based speckle contrast detection scheme are in agreement with Monte Carlo simulations and analytical calculations. This study complements previous UOT experiments that demonstrated optical absorption contrast.

© 2007 Optical Society of America

OCIS Codes
(030.6140) Coherence and statistical optics : Speckle
(110.6150) Imaging systems : Speckle imaging
(110.7050) Imaging systems : Turbid media
(110.7170) Imaging systems : Ultrasound
(170.3880) Medical optics and biotechnology : Medical and biological imaging

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: April 24, 2007
Revised Manuscript: June 27, 2007
Manuscript Accepted: July 2, 2007
Published: August 2, 2007

Virtual Issues
Vol. 2, Iss. 9 Virtual Journal for Biomedical Optics

Sri-Rajasekhar Kothapalli, Sava Sakadzic, Chulhong Kim, and Lihong V. Wang, "Imaging optically scattering objects with ultrasound-modulated optical tomography," Opt. Lett. 32, 2351-2353 (2007)

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  1. H. F. Zhang, K. Maslov, G. Stoica, and L.-H. Wang, Nat. Biotechnol. 24, 848 (2006). [CrossRef] [PubMed]
  2. D. A. Boas, D. H. Brooks, E. L. Miller, C. A. DiMarzio, M. Kilmer, R. J. Gaudette, and Q. Zhang, IEEE Signal Process. Lett. 18, 57 (2001).
  3. J. G. Fujimoto, Nat. Biotechnol. 21, 1361 (2003). [CrossRef] [PubMed]
  4. H. Inoue, S. Kudo, and A. Shiokawa, Nat. Clin. Pract. Gastroenterol. Hepatol. 2, 31 (2005). [CrossRef] [PubMed]
  5. A. D. Aguirre, Y. Chen, J. G. Fujimoto, L. Ruvinskaya, A. Devor, and D. A. Boas, Opt. Lett. 31, 3459 (2006). [CrossRef] [PubMed]
  6. S. Srinivasan, B. W. Pogue, S. Jiang, H. Dehghani, C. Kogel, S. Soho, J. J. Gibson, T. D. Tosteson, S. P. Poplack, and K. D. Paulsen, Proc. Natl. Acad. Sci. U.S.A. 100, 12349 (2003). [CrossRef] [PubMed]
  7. G. Gulsen, O. Birgul, M. B. Unlu, R. Shafiiha, and O. Nalcioglu, Technol. Cancer Res. Treat. 5, 351 (2006). [PubMed]
  8. H. Zhao, X. Gu, and H. Jiang, Opt. Commun. 238, 51 (2004). [CrossRef]
  9. L.-H. Wang, J. Dis. Mark. 19, 123 (2004).
  10. S. Leveque, A. C. Boccara, M. Lebec, and H. Saint-Jalmes, Opt. Lett. 24, 181 (1999). [CrossRef]
  11. A. Lev and B. G. Sfez, Opt. Lett. 28, 1549 (2003). [CrossRef] [PubMed]
  12. J. Li, G. Ku, and L.-H. V. Wang, Appl. Opt. 41, 6030 (2002). [CrossRef] [PubMed]
  13. S. Sakadzic and L.-H. V. Wang, Opt. Lett. 29, 2770 (2004). [CrossRef] [PubMed]
  14. T. W. Murray, L. Sui, G. Maguluri, R. A. Roy, A. Nieva, F. Blonigen, and C. A. DiMarzio, Opt. Lett. 29, 2509 (2004). [CrossRef] [PubMed]
  15. L.-H. V. Wang, Phys. Rev. Lett. 87, 043903 (2001). [CrossRef] [PubMed]
  16. S. Sakadzic and L.-H. V. Wang, Phys. Rev. Lett. 96, 163902 (2006). [CrossRef] [PubMed]
  17. S. Sakadzic and L.-H. V. Wang, Phys. Rev. E 72, 036620 (2005). [CrossRef]
  18. R. Zemp, S. Sakadzic, and L.-H. V. Wang, Phys. Rev. E 73, 061920 (2006). [CrossRef]
  19. C. Kim, R. J. Zemp, and L-H. V. Wang, Opt. Lett. 31, 2423 (2006). [CrossRef] [PubMed]
  20. G. Marquez and L.-H. V. Wang, Opt. Express 1, 454 (1997). [CrossRef] [PubMed]
  21. S. Sakadzic and L.-H. V. Wang, Phys. Rev. E 74, 036618 (2006). [CrossRef]

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