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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editor: Gregory W. Faris
  • Vol. 2, Iss. 9 — Sep. 26, 2007

Spectral-domain optical coherence reflectometric sensor for highly sensitive molecular detection

Chulmin Joo and Johannes F. de Boer  »View Author Affiliations


Optics Letters, Vol. 32, Issue 16, pp. 2426-2428 (2007)
http://dx.doi.org/10.1364/OL.32.002426


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Abstract

We describe what we believe to be a novel use of spectral-domain optical coherence reflectometry (SD-OCR) for highly sensitive molecular detection in real time. The SD-OCR sensor allows identification of a sensor surface of interest in an OCR depth scan and monitoring the phase alteration due to molecular interaction at that surface with subnanometer optical thickness sensitivity. We present subfemtomole detection sensitivity for etching of SiO 2 molecules and demonstrate its application as a biosensor by measuring biotin-streptavidin binding in a microfluidic device.

© 2007 Optical Society of America

OCIS Codes
(110.4500) Imaging systems : Optical coherence tomography
(120.3180) Instrumentation, measurement, and metrology : Interferometry
(280.0280) Remote sensing and sensors : Remote sensing and sensors

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: April 18, 2007
Revised Manuscript: July 3, 2007
Manuscript Accepted: July 11, 2007
Published: August 7, 2007

Virtual Issues
Vol. 2, Iss. 9 Virtual Journal for Biomedical Optics

Citation
Chulmin Joo and Johannes F. de Boer, "Spectral-domain optical coherence reflectometric sensor for highly sensitive molecular detection," Opt. Lett. 32, 2426-2428 (2007)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=ol-32-16-2426


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