Combined Raman spectroscopy and optical coherence tomography device for tissue characterization
Optics Letters, Vol. 33, Issue 10, pp. 1135-1137 (2008)
http://dx.doi.org/10.1364/OL.33.001135
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Abstract
We report a dual-modal device capable of sequential acquisition of Raman spectroscopy (RS) and optical coherence tomography (OCT) along a common optical axis. The device enhances application of both RS and OCT by precisely guiding RS acquisition with OCT images while also compensating for the lack of molecular specificity in OCT with the biochemical specificity of RS. We characterize the system performance and demonstrate the capability to identify structurally ambiguous features within an OCT image with RS in a scattering phantom, guide acquisition of RS from a localized malignancy in ex vivo breast tissue, and perform in vivo tissue analysis of a scab.
© 2008 Optical Society of America
OCIS Codes
(170.4500) Medical optics and biotechnology : Optical coherence tomography
(170.5660) Medical optics and biotechnology : Raman spectroscopy
(170.6510) Medical optics and biotechnology : Spectroscopy, tissue diagnostics
ToC Category:
Medical Optics and Biotechnology
History
Original Manuscript: January 31, 2008
Revised Manuscript: April 11, 2008
Manuscript Accepted: April 14, 2008
Published: May 14, 2008
Virtual Issues
Vol. 3, Iss. 6 Virtual Journal for Biomedical Optics
Citation
Chetan A. Patil, Nienke Bosschaart, Matthew D. Keller, Ton G. van Leeuwen, and Anita Mahadevan-Jansen, "Combined Raman spectroscopy and optical coherence tomography device for tissue characterization," Opt. Lett. 33, 1135-1137 (2008)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=ol-33-10-1135
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