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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics


  • Editor: Gregory W. Faris
  • Vol. 3, Iss. 6 — Jun. 17, 2008

Optical coherence Doppler tomography quantifies laser speckle contrast imaging for blood flow imaging in the rat cerebral cortex

Zhongchi Luo, Zhenguo Wang, Zhijia Yuan, Congwu Du, and Yingtian Pan  »View Author Affiliations

Optics Letters, Vol. 33, Issue 10, pp. 1156-1158 (2008)

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A dual-imaging modality is demonstrated for high-resolution quantitative imaging of local cerebral blood flow in the rat cortex by combining simultaneous spectral-domain Doppler optical coherence tomography (SDOCT) and full-field laser speckle contrast imaging (LSCI). Preliminary studies in tissue flow phantom and cocaine-induced cerebral blood flow changes indicated that by correlating coregistered cortical arterial blood flow, the relative measurement of flow changes by LSCI could be accurately calibrated by the absolute flow imaging provided by SDOCT (least square fit, r 2 0.96 ). Quantitative LSCI of cerebral blood flow is crucial to the quantitative analyses of the spatiotemporal hemodynamics of functional brain activations and thus improved understanding of neural process.

© 2008 Optical Society of America

OCIS Codes
(110.6150) Imaging systems : Speckle imaging
(170.3340) Medical optics and biotechnology : Laser Doppler velocimetry
(170.4500) Medical optics and biotechnology : Optical coherence tomography
(170.2655) Medical optics and biotechnology : Functional monitoring and imaging

ToC Category:
Imaging Systems

Original Manuscript: January 11, 2008
Revised Manuscript: April 5, 2008
Manuscript Accepted: April 10, 2008
Published: May 14, 2008

Virtual Issues
Vol. 3, Iss. 6 Virtual Journal for Biomedical Optics

Zhongchi Luo, Zhenguo Wang, Zhijia Yuan, Congwu Du, and Yingtian Pan, "Optical coherence Doppler tomography quantifies laser speckle contrast imaging for blood flow imaging in the rat cerebral cortex," Opt. Lett. 33, 1156-1158 (2008)

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