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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editor: Gregory W. Faris
  • Vol. 3, Iss. 4 — Apr. 23, 2008

Measurement of the hemoglobin oxygen saturation level with spectroscopic spectral-domain optical coherence tomography

Chih-Wei Lu, Cheng-Kuang Lee, Meng-Tsan Tsai, Yih-Ming Wang, and C. C. Yang  »View Author Affiliations


Optics Letters, Vol. 33, Issue 5, pp. 416-418 (2008)
http://dx.doi.org/10.1364/OL.33.000416


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Abstract

We report the measurement of the hemoglobin (Hb) oxygen saturation level in human blood with a spectroscopic spectral-domain optical coherence tomography (SSD-OCT) system based on the crossover behavior of Hb and oxyhemoglobin ( Hb O 2 ) absorption coefficients around 800 nm . By calculating the ratio of the exponential decay constant of A-mode scan signal in the long-wavelength range ( > 800 nm ) over that in the short-wavelength range ( < 800 nm ) , the relative oxygen saturation level of Hb can be calibrated. Such a relative level can be used for practical diagnosis application after a golden standard is built by comparing the variation of the OCT result with that of a conventional method, such as the use of a blood gas analyzer. In our experiment, the variation curve based on the SSD-OCT measurement, which has the advantages of noninvasive, real-time, and high-resolution measurements, is coincident with that of using a commercial blood gas analyzer.

© 2008 Optical Society of America

OCIS Codes
(170.1650) Medical optics and biotechnology : Coherence imaging
(180.1655) Microscopy : Coherence tomography

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: September 25, 2007
Revised Manuscript: January 18, 2008
Manuscript Accepted: January 19, 2008
Published: February 19, 2008

Virtual Issues
Vol. 3, Iss. 4 Virtual Journal for Biomedical Optics

Citation
Chih-Wei Lu, Cheng-Kuang Lee, Meng-Tsan Tsai, Yih-Ming Wang, and C. C. Yang, "Measurement of the hemoglobin oxygen saturation level with spectroscopic spectral-domain optical coherence tomography," Opt. Lett. 33, 416-418 (2008)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=ol-33-5-416


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