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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editor: Gregory W. Faris
  • Vol. 3, Iss. 4 — Apr. 23, 2008

Comparison of frequency-domain and time-domain fluorescence lifetime tomography

Anand T.N. Kumar, Scott B. Raymond, Brian J. Bacskai, and David A. Boas  »View Author Affiliations


Optics Letters, Vol. 33, Issue 5, pp. 470-472 (2008)
http://dx.doi.org/10.1364/OL.33.000470


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Abstract

We compare frequency-and time-domain formulations of deep-tissue fluorescence imaging of turbid media. Simulations are used to show that time-domain fluorescence tomography, implemented via the asymptotic lifetime-based approach, offers a significantly better separability of multiple lifetime targets than a frequency-domain approach. We also demonstrate experimentally, using complex-shaped phantoms, the advantages of the asymptotic time-domain approach over a Fourier-based approach for analyzing time-domain fluorescence data.

© 2008 Optical Society of America

OCIS Codes
(170.3650) Medical optics and biotechnology : Lifetime-based sensing
(170.3880) Medical optics and biotechnology : Medical and biological imaging

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: December 4, 2007
Revised Manuscript: January 17, 2008
Manuscript Accepted: January 22, 2008
Published: February 25, 2008

Virtual Issues
Vol. 3, Iss. 4 Virtual Journal for Biomedical Optics

Citation
Anand T. N. Kumar, Scott B. Raymond, Brian J. Bacskai, and David A. Boas, "Comparison of frequency-domain and time-domain fluorescence lifetime tomography," Opt. Lett. 33, 470-472 (2008)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=ol-33-5-470


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