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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editor: Gregory W. Faris
  • Vol. 3, Iss. 6 — Jun. 17, 2008

Optical measurement of neural activity using surface plasmon resonance

Shin Ae Kim, Kyung Min Byun, Jonghwan Lee, Jung Hoon Kim, Dong-Ghi Albert Kim, Hyoungwon Baac, Michael L. Shuler, and Sung June Kim  »View Author Affiliations


Optics Letters, Vol. 33, Issue 9, pp. 914-916 (2008)
http://dx.doi.org/10.1364/OL.33.000914


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Abstract

We demonstrate that surface plasmon resonance (SPR) is applicable to the optical detection of neural signals. A low-noise SPR sensor was developed as a label- and artifact-free method for the extracellular recording of neural activity. The optical responses obtained from a rat sciatic nerve were highly correlated with simultaneously recorded electrical responses. Additional studies with stimulation intensity and lidocaine further confirmed that the optically measured signals originated from neural activities.

© 2008 Optical Society of America

OCIS Codes
(240.0310) Optics at surfaces : Thin films
(240.6680) Optics at surfaces : Surface plasmons
(280.4788) Remote sensing and sensors : Optical sensing and sensors

ToC Category:
Optics at Surfaces

History
Original Manuscript: January 3, 2008
Revised Manuscript: March 3, 2008
Manuscript Accepted: March 12, 2008
Published: April 22, 2008

Virtual Issues
Vol. 3, Iss. 6 Virtual Journal for Biomedical Optics

Citation
Shin Ae Kim, Kyung Min Byun, Jonghwan Lee, Jung Hoon Kim, Dong-Ghi Albert Kim, Hyoungwon Baac, Michael L. Shuler, and Sung June Kim, "Optical measurement of neural activity using surface plasmon resonance," Opt. Lett. 33, 914-916 (2008)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=ol-33-9-914

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