Recently, there has been growing interest in the development of photoacoustic flow measuring methods aimed to study microvascular blood flow in biological tissue. Here, we describe the M-mode photoacoustic particle flow imaging, using an optical resolution photoacoustic microscope equipped with a high-repetition-rate pulsed dye laser. We studied the flow of a diluted dyed particle suspension in a small tube embedded in a nonscattering medium as well as in a scattering medium simulating biological tissue. Potentially, the method can be applied to detect the flow speed of single red blood cells in a capillary.
© 2009 Optical Society of America
Medical Optics and Biotechnology
Original Manuscript: November 24, 2008
Manuscript Accepted: December 23, 2008
Published: February 26, 2009
Vol. 4, Iss. 5 Virtual Journal for Biomedical Optics
Hui Fang and Lihong V. Wang, "M-mode photoacoustic particle flow imaging," Opt. Lett. 34, 671-673 (2009)