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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editor: Gregory W. Faris
  • Vol. 5, Iss. 2 — Jan. 21, 2010

Near-infrared tomography of breast cancer hemoglobin, water, lipid, and scattering using combined frequency domain and cw measurement

Jia Wang, Brian W. Pogue, Shudong Jiang, and Keith D. Paulsen  »View Author Affiliations


Optics Letters, Vol. 35, Issue 1, pp. 82-84 (2010)
http://dx.doi.org/10.1364/OL.35.000082


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Abstract

In this study, near-IR tomography was implemented in the wavelength range from 661 to 948 nm to characterize breast tumors in vivo. Frequency-domain measurements provide amplitude and phase transmitted at wavelengths below 850 nm , where photomultiplier tube detection is efficient. Continuous-wave detection at additional longer wavelengths (903, 912, and 948 nm ) was collected using a CCD-based spectrometer. Phantom validation experiments showed improved accuracy in hemoglobin and water concentrations using this technique. Three women with malignant breast tumors were studied. The addition of cw data at longer wavelengths increased the recovered contrast of water in the tumor region relative to surrounding tissue and allowed quantification of lipid.

© 2009 Optical Society of America

OCIS Codes
(170.0110) Medical optics and biotechnology : Imaging systems
(170.3880) Medical optics and biotechnology : Medical and biological imaging

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: June 10, 2009
Revised Manuscript: November 23, 2009
Manuscript Accepted: November 29, 2009
Published: December 31, 2009

Virtual Issues
Vol. 5, Iss. 2 Virtual Journal for Biomedical Optics

Citation
Jia Wang, Brian W. Pogue, Shudong Jiang, and Keith D. Paulsen, "Near-infrared tomography of breast cancer hemoglobin, water, lipid, and scattering using combined frequency domain and cw measurement," Opt. Lett. 35, 82-84 (2010)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=ol-35-1-82


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