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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editor: Gregory W. Faris
  • Vol. 5, Iss. 10 — Jul. 19, 2010

Hybrid-scanning optical-resolution photoacoustic microscopy for in vivo vasculature imaging

Bin Rao, Li Li, Konstantin Maslov, and Lihong Wang  »View Author Affiliations


Optics Letters, Vol. 35, Issue 10, pp. 1521-1523 (2010)
http://dx.doi.org/10.1364/OL.35.001521


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Abstract

Recently developed optical-resolution photoacoustic microscopy (OR-PAM), which is based on the detection of optical absorption contrast, is complementary to other optical microscopy modalities such as optical confocal microscopy, optical coherence tomography, and multiphoton microscopy. A hybrid optical–mechanical scanning configuration increases the imaging speed of OR-PAM significantly, facilitating many demanding biomedical applications. With a high-pulse-repetition-rate laser, the hybrid-scanning OR-PAM can acquire one-dimensional depth-resolved images (A-lines) at 5 kHz and two-dimensional B-scan images containing 800 A-lines at 6.25 Hz . We demonstrated in vivo in a mouse three-dimensional imaging of the iris vasculature in 128 s for an 800 × 800 × 200 data set and of the ear vasculature in 256 s for an 800 × 1600 × 200 data set.

© 2010 Optical Society of America

OCIS Codes
(110.0180) Imaging systems : Microscopy
(110.5120) Imaging systems : Photoacoustic imaging
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.5120) Medical optics and biotechnology : Photoacoustic imaging
(180.5810) Microscopy : Scanning microscopy

ToC Category:
Imaging Systems

History
Original Manuscript: February 11, 2010
Revised Manuscript: March 24, 2010
Manuscript Accepted: March 31, 2010
Published: May 5, 2010

Virtual Issues
Vol. 5, Iss. 10 Virtual Journal for Biomedical Optics

Citation
Bin Rao, Li Li, Konstantin Maslov, and Lihong Wang, "Hybrid-scanning optical-resolution photoacoustic microscopy for in vivo vasculature imaging," Opt. Lett. 35, 1521-1523 (2010)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=ol-35-10-1521

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