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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics


  • Editors: Andrew Dunn and Anthony Durkin
  • Vol. 5, Iss. 14 — Nov. 16, 2010

Full-field time-resolved fluorescence tomography of small animals

Vivek Venugopal, Jin Chen, Frederic Lesage, and Xavier Intes  »View Author Affiliations

Optics Letters, Vol. 35, Issue 19, pp. 3189-3191 (2010)

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In this experimental investigation, we explore the feasibility of using wide-field illumination for time-resolved fluorescence molecular tomography. The performance of wide-field patterns with a time-resolved imaging platform is investigated in vitro and in a small animal model. A Monte Carlo–based forward model is employed to reconstruct fluorescence yield based on time-gated datasets. An improvement in resolution and quantification when using the time-gate data type compared to the commonly used cw data type is demonstrated in vitro. Furthermore, the feasibility of wide-field strategies for fluorescence preclinical applications is established by an accurate localization of a fluorescent inclusion implanted in the chest cavity of a murine model.

© 2010 Optical Society of America

OCIS Codes
(170.3010) Medical optics and biotechnology : Image reconstruction techniques
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.6920) Medical optics and biotechnology : Time-resolved imaging
(170.6960) Medical optics and biotechnology : Tomography

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: May 27, 2010
Revised Manuscript: August 21, 2010
Manuscript Accepted: September 2, 2010
Published: September 21, 2010

Virtual Issues
Vol. 5, Iss. 14 Virtual Journal for Biomedical Optics

Vivek Venugopal, Jin Chen, Frederic Lesage, and Xavier Intes, "Full-field time-resolved fluorescence tomography of small animals," Opt. Lett. 35, 3189-3191 (2010)

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