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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics


  • Editors: Andrew Dunn and Anthony Durkin
  • Vol. 5, Iss. 14 — Nov. 16, 2010

Longitudinal, multimodal functional imaging of microvascular response to photothermal therapy

Albert K. Bui, Kathleen M. Teves, Elmer Indrawan, Wangcun Jia, and Bernard Choi  »View Author Affiliations

Optics Letters, Vol. 35, Issue 19, pp. 3216-3218 (2010)

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Although studies have shown that photothermal therapy can coagulate selectively abnormal vasculature, the ability of this method to achieve consistent, complete removal of the vasculature is questionable. We present the use of multimodal, wide-field functional imaging to study, in greater detail, the biological response to selective laser injury. Specifically, a single-platform instrument capable of coregistered fluorescence imaging and laser speckle imaging was utilized to monitor vascular endothelial growth factor gene expression and blood flow, respectively, in a transgenic rodent model. Collectively, the longitudinal, in vivo data collected with our instrument suggest that the biological response to selective laser injury involves early-stage redistribution of blood flow, followed by increased vascular endothelial growth factor promoter activity to stimulate pro-angiogenic events.

© 2010 Optical Society of America

OCIS Codes
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.6480) Medical optics and biotechnology : Spectroscopy, speckle
(170.2655) Medical optics and biotechnology : Functional monitoring and imaging

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: July 2, 2010
Manuscript Accepted: August 11, 2010
Published: September 22, 2010

Virtual Issues
Vol. 5, Iss. 14 Virtual Journal for Biomedical Optics

Albert K. Bui, Kathleen M. Teves, Elmer Indrawan, Wangcun Jia, and Bernard Choi, "Longitudinal, multimodal functional imaging of microvascular response to photothermal therapy," Opt. Lett. 35, 3216-3218 (2010)

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