OSA's Digital Library

Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editors: Andrew Dunn and Anthony Durkin
  • Vol. 6, Iss. 1 — Jan. 3, 2011

Utility of biodegradable plasmonic nanoclusters in photoacoustic imaging

Soon Joon Yoon, Srivalleesha Mallidi, Jasmine M. Tam, Justina O. Tam, Avinash Murthy, Keith P. Johnston, Konstantin V. Sokolov, and Stanislav Y. Emelianov  »View Author Affiliations


Optics Letters, Vol. 35, Issue 22, pp. 3751-3753 (2010)
http://dx.doi.org/10.1364/OL.35.003751


View Full Text Article

Enhanced HTML    Acrobat PDF (396 KB)





Browse Journals / Lookup Meetings

Browse by Journal and Year


   


Lookup Conference Papers

Close Browse Journals / Lookup Meetings

Article Tools

Share
Citations

Abstract

Plasmonic metal nanoparticles are used in photoacoustic imaging as contrast agents because of their resonant optical absorption properties in the visible and near-IR regions. However, the nanoparticles could accumulate and result in long-term toxicity in vivo, because they are generally not biodegradable. Recently, biodegradable plasmonic gold nanoclusters, consisting of sub- 5 nm primary gold nanoparticles and biodegradable polymer stabilizer, were introduced. In this Letter, we demonstrate the feasibility of biodegradable nanoclusters as a photoacoustic contrast agent. We performed photoacoustic and ultrasound imaging of a tissue-mimicking phantom with inclusions containing nanoclusters at various concentrations. The results indicate that the biodegradable gold nanoclusters can be used as effective contrast agents in photoacoustic imaging.

© 2010 Optical Society of America

OCIS Codes
(110.5120) Imaging systems : Photoacoustic imaging
(110.7170) Imaging systems : Ultrasound
(170.3880) Medical optics and biotechnology : Medical and biological imaging

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: August 13, 2010
Manuscript Accepted: September 20, 2010
Published: November 3, 2010

Virtual Issues
Vol. 6, Iss. 1 Virtual Journal for Biomedical Optics

Citation
Soon Joon Yoon, Srivalleesha Mallidi, Jasmine M. Tam, Justina O. Tam, Avinash Murthy, Keith P. Johnston, Konstantin V. Sokolov, and Stanislav Y. Emelianov, "Utility of biodegradable plasmonic nanoclusters in photoacoustic imaging," Opt. Lett. 35, 3751-3753 (2010)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=ol-35-22-3751


Sort:  Author  |  Year  |  Journal  |  Reset  

References

  1. P. Alivisatos, Nat. Biotechnol. 22, 47 (2003). [CrossRef]
  2. Y.-S. Chen, W. Frey, S. Kim, K. Homan, P. Kruizinga, K. Sokolov, and S. Emelianov, Opt. Express 18, 8867 (2010). [CrossRef] [PubMed]
  3. K. Homan, S. Kim, Y.-S. Chen, B. Wang, S. Mallidi, and S. Emelianov, Opt. Lett. 35, 2663 (2010). [CrossRef] [PubMed]
  4. S. Mallidi, T. Larson, J. Aaron, K. Sokolov, and S. Emelianov, Opt. Express 15, 6583 (2007). [CrossRef] [PubMed]
  5. B. Wang, E. Yantsen, T. Larson, A. B. Karpiouk, S. Sethuraman, J. L. Su, K. Sokolov, and S. Y. Emelianov, Nano Lett. 9, 2212 (2009). [CrossRef]
  6. S. Mallidi, T. Larson, J. Tam, P. P. Joshi, A. Karpiouk, K. Sokolov, and S. Emelianov, Nano Lett. 9, 2825 (2009). [CrossRef] [PubMed]
  7. N. Lewinski, V. Colvin, and R. Drezek, Small 4, 26 (2008). [CrossRef] [PubMed]
  8. H. S. Choi, W. Liu, P. Misra, E. Tanaka, J. P. Zimmer, B. I. Ipe, M. G. Bawendi, and J. V. Frangioni, Nat. Biotechnol. 25, 1165 (2007). [CrossRef] [PubMed]
  9. P. K. Jain, K. S. Lee, I. H. El-Sayed, and M. A. El-Sayed, J. Phys. Chem. B 110, 7238 (2006). [CrossRef] [PubMed]
  10. J. M. Tam, J. O. Tam, A. Murthy, D. R. Ingram, L. L. Ma, K. Travis, K. P. Johnston, and K. V. Sokolov, ACS Nano 4, 2178 (2010). [CrossRef] [PubMed]
  11. J. M. Tam, A. K. Murthy, D. R. Ingram, R. Nguyen, K. V. Sokolov, and K. P. Johnston, Langmuir 26, 8988 (2010). [CrossRef] [PubMed]
  12. J. Aaron, K. Travis, N. Harrison, and K. Sokolov, Nano Lett. 9, 3612 (2009). [CrossRef] [PubMed]
  13. J. K. Vasir and V. Labhasetwar, Adv. Drug Deliv. Rev. 59, 718 (2007). [CrossRef] [PubMed]
  14. K. Sokolov, M. Follen, J. Aaron, I. Pavlova, A. Malpica, R. Lotan, and R. Richards-Kortum, Cancer Res. 63, 1999(2003). [PubMed]
  15. J. Aaron, N. Nitin, K. Travis, S. Kumar, T. Collier, S. Y. Park, M. Jose-Yacaman, L. Coghlan, M. Follen, R. Richards-Kortum, and K. Sokolov, J. Biomed. Opt. 12, 034007 (2007). [CrossRef] [PubMed]

Cited By

Alert me when this paper is cited

OSA is able to provide readers links to articles that cite this paper by participating in CrossRef's Cited-By Linking service. CrossRef includes content from more than 3000 publishers and societies. In addition to listing OSA journal articles that cite this paper, citing articles from other participating publishers will also be listed.

Figures

Fig. 1 Fig. 2 Fig. 3
 
Fig. 4
 

« Previous Article  |  Next Article »

OSA is a member of CrossRef.

CrossCheck Deposited