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Label-free flow cytometry using multiplex coherent anti-Stokes Raman scattering (MCARS) for the analysis of biological specimens |
Optics Letters, Vol. 36, Issue 12, pp. 2309-2311 (2011)
http://dx.doi.org/10.1364/OL.36.002309
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Abstract
We present the first demonstration, to our knowledge, of a label-free flow cytometer for the analysis of biological specimens using multiplex coherent anti-Stokes Raman scattering (MCARS) and elastic scatter measurements. The MCARS system probes the Raman vibrational energy levels and the elastic scatter provides morphological information. We demonstrate these capabilities by probing a culture of Saccharomyces cerevisiae at
© 2011 Optical Society of America
OCIS Codes
(190.4380) Nonlinear optics : Nonlinear optics, four-wave mixing
(190.7110) Nonlinear optics : Ultrafast nonlinear optics
(300.6230) Spectroscopy : Spectroscopy, coherent anti-Stokes Raman scattering
ToC Category:
Nonlinear Optics
History
Original Manuscript: April 5, 2011
Revised Manuscript: May 11, 2011
Manuscript Accepted: May 18, 2011
Published: June 14, 2011
Virtual Issues
Vol. 6, Iss. 7 Virtual Journal for Biomedical Optics
Citation
Charles H. Camp, Jr., Siva Yegnanarayanan, Ali A. Eftekhar, and Ali Adibi, "Label-free flow cytometry using multiplex coherent anti-Stokes Raman scattering (MCARS) for the analysis of biological specimens," Opt. Lett. 36, 2309-2311 (2011)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=ol-36-12-2309
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