|
Focused cylindrical vector beam assisted microscopic pSPR biosensor with an ultra wide dynamic range |
Optics Letters, Vol. 37, Issue 11, pp. 2091-2093 (2012)
http://dx.doi.org/10.1364/OL.37.002091
Enhanced HTML 
Acrobat PDF (429 KB)
Abstract
A novel phase-sensitive surface plasmon resonance (pSPR) biosensor based on differential phase measurement between two cylindrical vector beams, namely radially polarized and azmuthally polarized beams, is proposed and studied in an inverted microscope. Different from a fixed angle or a relatively small angular range for SPR excitation in the attenuated total reflection (ATR) configuration, the signal beam focused by a total internal reflection fluorescence microscopic objective contains the entire angular range from 0 to the maximum angle given by the numerical aperture, leading to a dynamic range of 0.41 RIU which is over seven times wider than the best result of the ATR pSPR sensor. Moreover, with the technique of differential phase measurement between radial and azimuthal polarizations employed in our configuration, high sensitivity of
© 2012 Optical Society of America
OCIS Codes
(120.3180) Instrumentation, measurement, and metrology : Interferometry
(120.5060) Instrumentation, measurement, and metrology : Phase modulation
(170.3890) Medical optics and biotechnology : Medical optics instrumentation
(240.6680) Optics at surfaces : Surface plasmons
(180.4243) Microscopy : Near-field microscopy
ToC Category:
Medical Optics and Biotechnology
History
Original Manuscript: December 13, 2011
Revised Manuscript: February 21, 2012
Manuscript Accepted: April 11, 2012
Published: May 30, 2012
Virtual Issues
Vol. 7, Iss. 8 Virtual Journal for Biomedical Optics
Citation
Rong Wang, Chonglei Zhang, Yong Yang, Siwei Zhu, and X.-C. Yuan, "Focused cylindrical vector beam assisted microscopic pSPR biosensor with an ultra wide dynamic range," Opt. Lett. 37, 2091-2093 (2012)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=ol-37-11-2091
You do not have subscription access to this journal. Citation lists with outbound citation links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.
Contact your librarian or system administrator
or
Log in to access OSA Member Subscription
You do not have subscription access to this journal. Cited by links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.
Contact your librarian or system administrator
or
Log in to access OSA Member Subscription
You do not have subscription access to this journal. Figure files are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.
Contact your librarian or system administrator
or
Log in to access OSA Member Subscription
You do not have subscription access to this journal. Article level metrics are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.
Contact your librarian or system administrator
or
Log in to access OSA Member Subscription
Related Journal Articles 
- Measurement of the chromatic dispersion of an optical fiber by use of a Sagnac interferometer employing asymmetric modulation (OL)
- Surface plasmon resonance sensor based on polarization interferometry and angle modulation (AO)
- White-light spectral interferometry for surface plasmon resonance sensing applications (OE)
- Phase sensitive SPR sensor for wide dynamic range detection (OL)
- Wavelength-multiplexing phase-sensitive surface plasmon imaging sensor (OL)
« Previous Article | Next Article »
OSA is a member of 