We demonstrate interstitial diffuse optical time-of-fight spectroscopy based on a single fiber for both light delivery and detection. Detector saturation due to the massive short-time reflection is avoided by ultrafast gating of a single photon avalanche diode. We show that the effects of scattering and absorption are separable and that absorption can be assessed independently of scattering. Measurements on calibrated liquid phantoms and subsequent Monte Carlo–based evaluation illustrate that absorption coefficients can be accurately assessed over a wide range of medically relevant optical properties. Our findings pave the way to simplified and less invasive interstitial in vivo spectroscopy.
© 2012 Optical Society of America
Original Manuscript: December 22, 2011
Revised Manuscript: April 2, 2012
Manuscript Accepted: May 7, 2012
Published: July 11, 2012
Vol. 7, Iss. 9 Virtual Journal for Biomedical Optics
Erik Alerstam, Tomas Svensson, Stefan Andersson-Engels, Lorenzo Spinelli, Davide Contini, Alberto Dalla Mora, Alberto Tosi, Franco Zappa, and Antonio Pifferi, "Single-fiber diffuse optical time-of-flight spectroscopy," Opt. Lett. 37, 2877-2879 (2012)