OSA's Digital Library

Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editor: Gregory W. Faris
  • Vol. 1, Iss. 7 — Jul. 17, 2006

Steady-state directional diffuse reflectance and fluorescence of human skin

Kamal M. Katika and Laurent Pilon  »View Author Affiliations


Applied Optics, Vol. 45, Issue 17, pp. 4174-4183 (2006)
http://dx.doi.org/10.1364/AO.45.004174


View Full Text Article

Enhanced HTML    Acrobat PDF (811 KB)





Browse Journals / Lookup Meetings

Browse by Journal and Year


   


Lookup Conference Papers

Close Browse Journals / Lookup Meetings

Article Tools

Share
Citations

Abstract

We present numerical simulations predicting the directional diffuse reflectance and autofluorescence from human skin. Skin is modeled as a seven-layered medium, with each layer having its own optical properties and fluorophore concentrations. Both collimated and diffuse monochromatic excitation at 442 ‚ÄČ nm are considered. In addition, the effect of an index-matching cream used to eliminate total internal reflection within the skin is assessed. We compute the intensity distributions of the excitation and fluorescence light in the skin by solving the radiative transfer equation using the modified method of characteristics. It was found that the use of an index-matching cream reduces the directional fluorescence signal while increasing the directional diffuse reflectance from the skin for collimated excitation. On the other hand, both the fluorescence and diffuse reflectance increase for diffuse excitation with an index-matching cream. Moreover, the directional fluorescence intensity obtained by use of collimated excitation is larger than that obtained by use of diffuse excitation light. This computational tool could be valuable in designing optical devices for biomedical applications.

© 2006 Optical Society of America

OCIS Codes
(170.3660) Medical optics and biotechnology : Light propagation in tissues
(170.7050) Medical optics and biotechnology : Turbid media
(290.7050) Scattering : Turbid media
(300.2530) Spectroscopy : Fluorescence, laser-induced

History
Original Manuscript: May 9, 2005
Revised Manuscript: September 12, 2005
Manuscript Accepted: January 5, 2006

Virtual Issues
Vol. 1, Iss. 7 Virtual Journal for Biomedical Optics

Citation
Kamal M. Katika and Laurent Pilon, "Steady-state directional diffuse reflectance and fluorescence of human skin," Appl. Opt. 45, 4174-4183 (2006)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=ao-45-17-4174

You do not have subscription access to this journal. Citation lists with outbound citation links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Log in to access OSA Member Subscription

You do not have subscription access to this journal. Cited by links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Log in to access OSA Member Subscription

You do not have subscription access to this journal. Figure files are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Log in to access OSA Member Subscription

You do not have subscription access to this journal. Article level metrics are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Log in to access OSA Member Subscription

« Previous Article  |  Next Article »

OSA is a member of CrossRef.

CrossCheck Deposited