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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics


  • Editor: Gregory W. Faris
  • Vol. 1, Iss. 12 — Dec. 18, 2006

Quantitative reconstruction of refractive index distribution and imaging of glucose concentration by using diffusing light

Xiaoping Liang, Qizhi Zhang, and Huabei Jiang  »View Author Affiliations

Applied Optics, Vol. 45, Issue 32, pp. 8360-8365 (2006)

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We show that a two-step reconstruction method can be adapted to improve the quantitative accuracy of the refractive index reconstruction in phase-contrast diffuse optical tomography (PCDOT). We also describe the possibility of imaging tissue glucose concentration with PCDOT. In this two-step method, we first use our existing finite-element reconstruction algorithm to recover the position and shape of a target. We then use the position and size of the target as a priori information to reconstruct a single value of the refractive index within the target and background regions using a region reconstruction method. Due to the extremely low contrast available in the refractive index reconstruction, we incorporate a data normalization scheme into the two-step reconstruction to combat the associated low signal-to-noise ratio. Through a series of phantom experiments we find that this two-step reconstruction method can considerably improve the quantitative accuracy of the refractive index reconstruction. The results show that the relative error of the reconstructed refractive index is reduced from 20 % to within 1.5 % . We also demonstrate the possibility of PCDOT for recovering glucose concentration using these phantom experiments.

© 2006 Optical Society of America

OCIS Codes
(170.5280) Medical optics and biotechnology : Photon migration
(170.6960) Medical optics and biotechnology : Tomography

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: February 14, 2006
Revised Manuscript: June 13, 2006
Manuscript Accepted: July 7, 2006

Virtual Issues
Vol. 1, Iss. 12 Virtual Journal for Biomedical Optics

Xiaoping Liang, Qizhi Zhang, and Huabei Jiang, "Quantitative reconstruction of refractive index distribution and imaging of glucose concentration by using diffusing light," Appl. Opt. 45, 8360-8365 (2006)

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