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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editor: Gregory W. Faris
  • Vol. 1, Iss. 3 — Mar. 7, 2006

Computer-controlled optical scanning tile microscope

C. Wang, P. Shumyatsky, F. Zeng, M. Zevallos, and R. R. Alfano  »View Author Affiliations


Applied Optics, Vol. 45, Issue 6, pp. 1148-1152 (2006)
http://dx.doi.org/10.1364/AO.45.001148


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Abstract

A new type of computer-controlled optical scanning, high-magnification imaging system with a large field of view is described that overcomes the commonly believed incompatibility of achieving both high magnification and a large field of view. The new system incorporates galvanometer scanners, a CCD camera, and a high-brightness LED source for the fast acquisition of a large number of a high-resolution segmented tile images with a magnification of 800 × for each tile. The captured segmented tile images are combined to create an effective enlarged view of a target totaling 1.6   mm × 1 .2   mm in area. The speed and sensitivity of the system make it suitable for high-resolution imaging and monitoring of a small segmented area of 320 μ m × 240   μ m with 4   μ m resolution. Each tile segment of the target can be zoomed up without loss of the high resolution. This new microscope imaging system gives both high magnification and a large field of view. This microscope can be utilized in medicine, biology, semiconductor inspection, device analysis, and quality control.

© 2006 Optical Society of America

OCIS Codes
(110.0180) Imaging systems : Microscopy
(180.0180) Microscopy : Microscopy
(180.5810) Microscopy : Scanning microscopy

ToC Category:
Microscopy

History
Original Manuscript: June 28, 2005
Revised Manuscript: September 26, 2005
Manuscript Accepted: October 1, 2005

Virtual Issues
Vol. 1, Iss. 3 Virtual Journal for Biomedical Optics

Citation
C. Wang, P. Shumyatsky, F. Zeng, M. Zevallos, and R. R. Alfano, "Computer-controlled optical scanning tile microscope," Appl. Opt. 45, 1148-1152 (2006)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=ao-45-6-1148


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