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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics


  • Editor: Gregory W. Faris
  • Vol. 1, Iss. 4 — Apr. 12, 2006

Optical waveguide biosensors constructed with subwavelength gratings

Jenq-Nan Yih, Yi-Ming Chu, Yen-Chieh Mao, Wei-Han Wang, Fan-Ching Chien, Chun-Yu Lin, Kuang-Li Lee, Pei-Kuen Wei, and Shean-Jen Chen  »View Author Affiliations

Applied Optics, Vol. 45, Issue 9, pp. 1938-1942 (2006)

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The reflection resonance spectrum of a subwavelength diffraction-grating-coupled waveguide is used to analyze biomolecular interactions in real time. By detecting this resonance wavelength shift, the optical waveguide biosensor provides the ability to identify the kinetics of the biomolecular interaction on an on-line basis without the need for extrinsic labeling of the biomolecules. A theoretical analysis of the subwavelength optical waveguide biosensor is performed. A biosensor with a narrow reflection resonance spectrum, and hence an enhanced detection resolution, is then designed and fabricated. Currently, the detection limit of the optical waveguide sensor is approximately 10 5 refractive-index units. The biosensor is successfully applied to study of the dynamic response of an antibody interaction with protein G adsorbed on the sensing surface.

© 2006 Optical Society of America

OCIS Codes
(170.1460) Medical optics and biotechnology : Blood gas monitoring
(230.1950) Optical devices : Diffraction gratings

ToC Category:
Optical Devices

Original Manuscript: July 27, 2005
Revised Manuscript: September 29, 2005
Manuscript Accepted: October 22, 2005

Virtual Issues
Vol. 1, Iss. 4 Virtual Journal for Biomedical Optics

Jenq-Nan Yih, Yi-Ming Chu, Yen-Chieh Mao, Wei-Han Wang, Fan-Ching Chien, Chun-Yu Lin, Kuang-Li Lee, Pei-Kuen Wei, and Shean-Jen Chen, "Optical waveguide biosensors constructed with subwavelength gratings," Appl. Opt. 45, 1938-1942 (2006)

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