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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editor: Gregory W. Faris
  • Vol. 2, Iss. 5 — May. 17, 2007

Image correction algorithm for functional three-dimensional diffuse optical tomography brain imaging

Yong Xu, Harry L. Graber, and Randall L. Barbour  »View Author Affiliations


Applied Optics, Vol. 46, Issue 10, pp. 1693-1704 (2007)
http://dx.doi.org/10.1364/AO.46.001693


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Abstract

We outline a computationally efficient image correction algorithm, which we have applied to diffuse optical tomography (DOT) image time series derived from a magnetic resonance imaging (MRI)-based brain model. Results show that the algorithm increases spatial resolution, decreases spatial bias, and only modestly reduces temporal accuracy for noise levels typically seen in experiment, and produces results comparable to image reconstructions that incorporate information from MRI priors. We demonstrate that this algorithm has robust performance in the presence of noise, background heterogeneity, irregular external and internal boundaries, and error in the initial guess. However, the algorithm introduces artifacts when the absorption and scattering coefficients of the reference medium are overestimated—a situation that is easily avoided in practice. The considered algorithm offers a practical approach to improving the quality of images from time-series DOT, even without the use of MRI priors.

© 2007 Optical Society of America

OCIS Codes
(100.1830) Image processing : Deconvolution
(100.2980) Image processing : Image enhancement
(100.6890) Image processing : Three-dimensional image processing
(100.6950) Image processing : Tomographic image processing
(170.3010) Medical optics and biotechnology : Image reconstruction techniques
(170.3880) Medical optics and biotechnology : Medical and biological imaging

ToC Category:
Diffuse optical imaging

History
Original Manuscript: July 10, 2006
Revised Manuscript: November 7, 2006
Manuscript Accepted: November 8, 2006
Published: March 13, 2007

Virtual Issues
Vol. 2, Iss. 5 Virtual Journal for Biomedical Optics

Citation
Yong Xu, Harry L. Graber, and Randall L. Barbour, "Image correction algorithm for functional three-dimensional diffuse optical tomography brain imaging," Appl. Opt. 46, 1693-1704 (2007)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=ao-46-10-1693

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