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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editor: Gregory W. Faris
  • Vol. 2, Iss. 5 — May. 17, 2007

In vivo time-resolved reflectance spectroscopy of the human forehead

Daniela Comelli, Andrea Bassi, Antonio Pifferi, Paola Taroni, Alessandro Torricelli, Rinaldo Cubeddu, Fabrizio Martelli, and Giovanni Zaccanti  »View Author Affiliations


Applied Optics, Vol. 46, Issue 10, pp. 1717-1725 (2007)
http://dx.doi.org/10.1364/AO.46.001717


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Abstract

We present an in vivo broadband spectroscopic characterization of the human forehead. Absorption and scattering properties are measured on five healthy volunteers at five different interfiber distances, using time-resolved diffuse spectroscopy and interpreting data with a model of the diffusion equation for a homogeneous semi-infinite medium. A wavelength-tunable mode-locked laser and time-correlated single-photon counting detection are employed, enabling fully spectroscopic measurements in the range of 700–1000 nm. The results show a large variation in the absorption and scattering properties of the head depending on the subject, whereas intrasubject variations, assessed at different interfiber distances, appear less relevant, particularly for what concerns the absorption coefficient. The high intersubject variability observed indicates that a unique set of optical properties for modeling the human head cannot be used correctly. To better interpret the results of the analysis of in vivo measurements, we performed a set of four-layer model Monte Carlo simulations based on different data sets for the optical properties of the human head, partially derived from the literature. The analysis indicated that, when simulated time-resolved curves are fitted with a homogeneous model for the photon migration, the retrieved absorption and reduced scattering coefficients are much closer to superficial layer values (i.e., scalp and skull) than to deeper layer ones (white and gray matter). In particular, for the shorter interfiber distances, the recovered values can be assumed as a good estimate of the optical properties of the first layer.

© 2007 Optical Society of America

OCIS Codes
(170.3660) Medical optics and biotechnology : Light propagation in tissues
(170.5280) Medical optics and biotechnology : Photon migration
(170.7050) Medical optics and biotechnology : Turbid media
(300.6500) Spectroscopy : Spectroscopy, time-resolved

ToC Category:
Diffuse optical imaging

History
Original Manuscript: July 18, 2006
Revised Manuscript: October 18, 2006
Manuscript Accepted: November 17, 2006
Published: March 13, 2007

Virtual Issues
Vol. 2, Iss. 5 Virtual Journal for Biomedical Optics

Citation
Daniela Comelli, Andrea Bassi, Antonio Pifferi, Paola Taroni, Alessandro Torricelli, Rinaldo Cubeddu, Fabrizio Martelli, and Giovanni Zaccanti, "In vivo time-resolved reflectance spectroscopy of the human forehead," Appl. Opt. 46, 1717-1725 (2007)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=ao-46-10-1717


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