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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editor: Gregory W. Faris
  • Vol. 2, Iss. 5 — May. 17, 2007

Correlation between optical coherence tomography images and histology of pigskin

Roman Kuranov, Veronika Sapozhnikova, Donald Prough, Inga Cicenaite, and Rinat Esenaliev  »View Author Affiliations


Applied Optics, Vol. 46, Issue 10, pp. 1782-1786 (2007)
http://dx.doi.org/10.1364/AO.46.001782


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Abstract

Noninvasive imaging techniques such as optical coherence tomography (OCT) are being widely used for early diagnostics of a variety of pathologies. Traditional tissue preparation for histological evaluation alters the dimensions of histological images such that differences between the dimensions of histologic and OCT images can be as great as 2.5-fold. This discrepancy complicates quantitative interpretation of OCT images. Here we used a steel ring sewn to the pigskin to avoid tissue deformation due to excision and fixation and used a surgical suture as a fixed tissue marker. With these techniques, we achieved good correlation between OCT and histological images with differences of less than 10%. The resulting method significantly enhances the diagnostic capabilities of the OCT technique.

© 2007 Optical Society of America

OCIS Codes
(110.2960) Imaging systems : Image analysis
(170.4500) Medical optics and biotechnology : Optical coherence tomography
(170.4580) Medical optics and biotechnology : Optical diagnostics for medicine

ToC Category:
Optical Coherence Tomography

History
Original Manuscript: July 3, 2006
Manuscript Accepted: October 27, 2006
Published: March 13, 2007

Virtual Issues
Vol. 2, Iss. 5 Virtual Journal for Biomedical Optics

Citation
Roman Kuranov, Veronika Sapozhnikova, Donald Prough, Inga Cicenaite, and Rinat Esenaliev, "Correlation between optical coherence tomography images and histology of pigskin," Appl. Opt. 46, 1782-1786 (2007)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=ao-46-10-1782


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