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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editor: Gregory W. Faris
  • Vol. 2, Iss. 5 — May. 17, 2007

Long-term optical imaging of intrinsic signals in anesthetized and awake monkeys

Anna W. Roe  »View Author Affiliations


Applied Optics, Vol. 46, Issue 10, pp. 1872-1880 (2007)
http://dx.doi.org/10.1364/AO.46.001872


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Abstract

Some exciting new efforts to use intrinsic signal optical imaging methods for long-term studies in anesthetized and awake monkeys are reviewed. The development of such methodologies opens the door for studying behavioral states such as attention, motivation, memory, emotion, and other higher-order cognitive functions. Long-term imaging is also ideal for studying changes in the brain that accompany development, plasticity, and learning. Although intrinsic imaging lacks the temporal resolution offered by dyes, it is a high spatial resolution imaging method that does not require application of any external agents to the brain. The bulk of procedures described here have been developed in the monkey but can be applied to the study of surface structures in any in vivo preparation.

© 2007 Optical Society of America

OCIS Codes
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(330.7310) Vision, color, and visual optics : Vision

ToC Category:
Optics in neuroscience

History
Original Manuscript: July 7, 2006
Revised Manuscript: October 31, 2006
Manuscript Accepted: November 3, 2006
Published: March 13, 2007

Virtual Issues
Vol. 2, Iss. 5 Virtual Journal for Biomedical Optics

Citation
Anna W. Roe, "Long-term optical imaging of intrinsic signals in anesthetized and awake monkeys," Appl. Opt. 46, 1872-1880 (2007)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=ao-46-10-1872


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