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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics


  • Editor: Gregory W. Faris
  • Vol. 2, Iss. 5 — May. 17, 2007

Integrated semiconductor optical sensors for cellular and neural imaging

Ofer Levi, Thomas T. Lee, Meredith M. Lee, Stephen J Smith, and James S. Harris  »View Author Affiliations

Applied Optics, Vol. 46, Issue 10, pp. 1881-1889 (2007)

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We review integrated optical sensors for functional brain imaging, localized index-of-refraction sensing as part of a lab-on-a-chip, and in vivo continuous monitoring of tumor and cancer stem cells. We present semiconductor-based sensors and imaging systems for these applications. Measured intrinsic optical signals and tissue optics simulations indicate the need for high dynamic range and low dark-current neural sensors. Simulated and measured reflectance spectra from our guided resonance filter demonstrate the capability for index-of-refraction sensing on cellular scales, compatible with integrated biosensors. Finally, we characterized a thermally evaporated emission filter that can be used to improve sensitivity for in vivo fluorescence sensing.

© 2007 Optical Society of America

OCIS Codes
(130.5990) Integrated optics : Semiconductors
(130.6010) Integrated optics : Sensors
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(250.7260) Optoelectronics : Vertical cavity surface emitting lasers

ToC Category:
Optics in neuroscience

Original Manuscript: July 10, 2006
Revised Manuscript: November 21, 2006
Manuscript Accepted: November 22, 2006
Published: March 13, 2007

Virtual Issues
Vol. 2, Iss. 5 Virtual Journal for Biomedical Optics

Ofer Levi, Thomas T. Lee, Meredith M. Lee, Stephen J Smith, and James S. Harris, "Integrated semiconductor optical sensors for cellular and neural imaging," Appl. Opt. 46, 1881-1889 (2007)

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