OSA's Digital Library

Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editor: Gregory W. Faris
  • Vol. 2, Iss. 5 — May. 17, 2007

Strategy for photostable proximity bioassays using lanthanides

Jeanne P. Haushalter and Gregory W. Faris  »View Author Affiliations


Applied Optics, Vol. 46, Issue 10, pp. 1918-1923 (2007)
http://dx.doi.org/10.1364/AO.46.001918


View Full Text Article

Enhanced HTML    Acrobat PDF (958 KB)





Browse Journals / Lookup Meetings

Browse by Journal and Year


   


Lookup Conference Papers

Close Browse Journals / Lookup Meetings

Article Tools

Share
Citations

Abstract

We report initial findings for research aimed at creating photostable lanthanide chelate reporters for proximity assays. These reporters take advantage of the nanometer-scale distance dependence of fluorescence enhancement for molecules in the vicinity of noble metal nanoparticles and also capitalize on some unique properties of lanthanide chelates. This approach promises to lead to proximity assays that do not suffer from photobleaching and offer very high on∕off enhancement ratios. Results for lanthanide chelates on silver island films and in colloidal suspensions are reported. Enhancement factors range from 1 to 2 orders of magnitude, with larger enhancements for strongly quenched lanthanides.

© 2007 Optical Society of America

OCIS Codes
(170.4580) Medical optics and biotechnology : Optical diagnostics for medicine
(170.6280) Medical optics and biotechnology : Spectroscopy, fluorescence and luminescence
(240.6680) Optics at surfaces : Surface plasmons

ToC Category:
Optical nanotechnology

History
Original Manuscript: June 30, 2006
Revised Manuscript: October 12, 2006
Manuscript Accepted: October 23, 2006
Published: March 13, 2007

Virtual Issues
Vol. 2, Iss. 5 Virtual Journal for Biomedical Optics

Citation
Jeanne P. Haushalter and Gregory W. Faris, "Strategy for photostable proximity bioassays using lanthanides," Appl. Opt. 46, 1918-1923 (2007)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=ao-46-10-1918


Sort:  Author  |  Year  |  Journal  |  Reset  

References

  1. D. L. Jeanmaire and R. P. Vanduyne, "Surface Raman spectroelectrochemistry. 1. Heterocyclic, aromatic, and aliphatic-amines adsorbed on anodized silver electrode," J Electroanal. Chem. Interfacial Electrochem. 84, 1-20 (1977). [CrossRef]
  2. A. Wokaun, "Surface enhancement of optical fields. Mechanisms and applications," Mol. Phys. 56, 1-33 (1985). [CrossRef]
  3. R. Aroca, G. J. Kovacs, C. A. Jennings, R. O. Loutfy, and P. S. Vincett, "Fluorescent enhancement from Langmuir-Blodgett monolayers on silver island films," Langmuir 4, 518-521 (1988). [CrossRef]
  4. J. Malicka, I. Gryczynski, Z. Gryczynski, and J. R. Lakowicz, "Effects of fluorophore-to-silver distance on the emission of cyanine-dye-labeled oligonucleotides," Anal. Biochem. 315, 57-66 (2003). [CrossRef] [PubMed]
  5. D. A. Weitz, S. Garoff, C. D. Hanson, T. J. Gramila, and J. I. Gersten, "Fluorescent lifetimes of molecules on silver-island films," Opt. Lett. 7, 89-91 (1982). [CrossRef] [PubMed]
  6. J. R. Lakowicz, "Radiative decay engineering: biophysical and biomedical applications," Anal. Biochem. 298, 1-24 (2001). [CrossRef] [PubMed]
  7. J. R. Lakowicz, J. Malicka, and I. Gryczynski, "Increased intensities of YOYO-l-labeled DNA oligomers near silver particles," Photochem. Photobiol. 77, 604-607 (2003). [CrossRef] [PubMed]
  8. J. Malicka, I. Gryczynski, C. D. Geddes, and J. R. Lakowicz, "Metal-enhanced emission from indocyanine green: a new approach to in vivo imaging," J. Biomed. Opt. 8, 472-478 (2003). [CrossRef] [PubMed]
  9. A. Parfenov, I. Gryczynski, J. Malicka, C. D. Geddes, and J. R. Lakowicz, "Enhanced fluorescence from fluorophores on fractal silver surfaces," J. Phys. Chem. B 107, 8829-8833 (2003). [CrossRef] [PubMed]
  10. E. Matveeva, Z. Gryczynski, J. B. Malicka, I. Gryczynski, and J. R. Lakowicz, "Metal-enhanced fluorescent biomarkers for cardiac risk assessment," Proc. SPIE 5327, 45-52 (2004). [CrossRef]
  11. J. R. Lakowicz, C. D. Geddes, I. Gryczynski, J. B. Malicka, Z. Gryczynski, K. Aslan, J. Lukomska, and J. Huang, "Advances in surface-enhanced fluorescence," Proc. SPIE 5327, 10-28 (2004). [CrossRef]
  12. J. R. Lakowicz, M. H. Chowdhury, K. Ray, J. Zhang, Y. Fu, R. Badugu, C. R. Sabanayagam, K. Nowaczyk, H. Szmacinski, K. Aslan, and C. D. Geddes, "Plasmon-controlled fluorescence: a new detection technology," Proc. SPIE 6099, 34-48 (2006).
  13. F. Yu, D. Yao, and W. Knoll, "Surface plasmon field-enhanced fluorescence spectroscopy studies of the interaction between an antibody and its surface-coupled antigen," Anal. Chem. 75, 2610-2617 (2003). [CrossRef] [PubMed]
  14. K. Sokolov, G. Chumanov, and T. M. Cotton, "Enhancement of molecular fluorescence near the surface of colloidal metal films," Anal. Chem. 70, 3898-3905 (1998). [CrossRef] [PubMed]
  15. I. Hemmila, S. Dakubu, V. M. Mukkala, H. Siitari, and T. Lovgren, "Europium as a label in time-resolved immunofluorometric assays," Anal. Biochem. 137, 335-343 (1984). [CrossRef] [PubMed]
  16. E. F. Dickson, A. Pollak, and E. P. Diamandis, "Time-resolved detection of lanthanide luminescence for ultrasensitive bioanalytical assays," J. Photochem. Photobiol. B 27, 3-19 (1995). [CrossRef] [PubMed]
  17. D. A. Zarling, M. Rossi, N. A. Peppers, J. Kane, G. W. Faris, M. J. Dyer, S. Y. Ng, and L. V. Schneider, "Up-converting reporters for biological and other assays using laser excitation techniques (upconverting chelate patent)," U.S. patent 5,891, 656 (6 April 1999).
  18. X. Xiao, J. P. Haushalter, and G. W. Faris, "Upconversion from aqueous phase lanthanide chelates," Opt. Lett. 30, 1674-1676 (2005). [CrossRef] [PubMed]
  19. J. R. Lakowicz, B. P. Maliwal, J. Malicka, Z. Gryczynski, and I. Gryczynski, "Effects of silver island films on the luminescent intensity and decay times of lanthanide chelates," J. Fluoresc. 12, 431-437 (2002). [CrossRef]
  20. H. Nabika and S. Deki, "Surface-enhanced luminescence from Eu3+ complex nearby Ag colloids," Eur. Phys. J. D 24, 369-372 (2003). [CrossRef]
  21. W. Stöber, A. Fink, and E. Bohn, "Controlled growth of monodisperse silica spheres in the micron size range," J. Colloid Interface Sci. 26, 62-69 (1968). [CrossRef]
  22. R. Gupta, M. J. Dyer, and W. A. Weimer, "Preparation and characterization of surface plasmon resonance tunable gold and silver films," J. Appl. Phys. 92, 5264-5271 (2002). [CrossRef]
  23. P. J. Tarcha, J. Desaja-Gonzalez, S. Rodriguez-Llorente, and R. Aroca, "Surface-enhanced fluorescence on SiO2-coated silver island films," Appl. Spectrosc. 53, 43-48 (1999). [CrossRef]

Cited By

Alert me when this paper is cited

OSA is able to provide readers links to articles that cite this paper by participating in CrossRef's Cited-By Linking service. CrossRef includes content from more than 3000 publishers and societies. In addition to listing OSA journal articles that cite this paper, citing articles from other participating publishers will also be listed.


« Previous Article  |  Next Article »

OSA is a member of CrossRef.

CrossCheck Deposited