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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editor: Gregory W. Faris
  • Vol. 2, Iss. 5 — May. 17, 2007

Photonic explorers based on multifunctional nanoplatforms for biosensing and photodynamic therapy

Yong-Eun Lee Koo, Wenzhe Fan, Hoejin Hah, Hao Xu, Dan Orringer, Brian Ross, Alnawaz Rehemtulla, Martin A. Philbert, and Raoul Kopelman  »View Author Affiliations


Applied Optics, Vol. 46, Issue 10, pp. 1924-1930 (2007)
http://dx.doi.org/10.1364/AO.46.001924


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Abstract

Nanoparticle-based photonic explorers have been developed for intracellular sensing and photodynamic therapy (PDT). The design employs nanoparticles made of various matrices as multifunctional nanoplatforms, loading active components by encapsulation or covalent attachment. The nanoplatform for biosensing has been successfully applied to intracellular measurements of important ionic and molecular species. The nanoplatform for PDT has shown high therapeutic efficacy in a rat 9L gliosarcoma model. Specifically, a multifunctional nanoplatform that encompasses magnetic resonance imaging (MRI) and PDT agents inside, as well as targeting ligands on the surface, has been developed and applied in vivo, resulting in much improved MRI contrast enhancement and PDT efficacy.

© 2007 Optical Society of America

OCIS Codes
(170.0170) Medical optics and biotechnology : Medical optics and biotechnology
(170.3880) Medical optics and biotechnology : Medical and biological imaging

ToC Category:
Optical nanotechnology

History
Original Manuscript: June 30, 2006
Revised Manuscript: October 13, 2006
Manuscript Accepted: October 16, 2006
Published: March 13, 2007

Virtual Issues
Vol. 2, Iss. 5 Virtual Journal for Biomedical Optics

Citation
Yong-Eun Lee Koo, Wenzhe Fan, Hoejin Hah, Hao Xu, Dan Orringer, Brian Ross, Alnawaz Rehemtulla, Martin A. Philbert, and Raoul Kopelman, "Photonic explorers based on multifunctional nanoplatforms for biosensing and photodynamic therapy," Appl. Opt. 46, 1924-1930 (2007)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=ao-46-10-1924

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