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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editor: Gregory W. Faris
  • Vol. 2, Iss. 5 — May. 17, 2007

Analysis of total uncertainty in spectral peak measurements for plasmonic nanoparticle-based biosensors

Adam Curry, Gregory Nusz, Ashutosh Chilkoti, and Adam Wax  »View Author Affiliations


Applied Optics, Vol. 46, Issue 10, pp. 1931-1939 (2007)
http://dx.doi.org/10.1364/AO.46.001931


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Abstract

One goal of recent research on plasmonic nanoparticle-based sensors is maximizing nanoparticle sensitivity or shift of resonance peak wavelength per refractive index change. Equally important is a measurement system's peak location uncertainty or shift resolution. We provide systematic analyses and discuss optimization of factors that determine peak location uncertainty, reporting values as low as 0.3 nm for the presented scheme. This type of analysis is important, in part, because it provides a means of evaluating detection thresholds for biosensor applications such as analyte binding. We estimate thresholds of 310 streptavidin molecules for the presented scheme and 20 molecules with system improvements.

© 2007 Optical Society of America

OCIS Codes
(180.0180) Microscopy : Microscopy
(290.0290) Scattering : Scattering
(300.0300) Spectroscopy : Spectroscopy
(350.4990) Other areas of optics : Particles

ToC Category:
Optical nanotechnology

History
Original Manuscript: July 3, 2006
Revised Manuscript: September 26, 2006
Manuscript Accepted: October 16, 2006
Published: March 13, 2007

Virtual Issues
Vol. 2, Iss. 5 Virtual Journal for Biomedical Optics

Citation
Adam Curry, Gregory Nusz, Ashutosh Chilkoti, and Adam Wax, "Analysis of total uncertainty in spectral peak measurements for plasmonic nanoparticle-based biosensors," Appl. Opt. 46, 1931-1939 (2007)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=ao-46-10-1931


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