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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editor: Gregory W. Faris
  • Vol. 2, Iss. 5 — May. 17, 2007

Two-dimensional biosensor arrays based on surface plasmon resonance phase imaging

C. L. Wong, H. P. Ho, T. T. Yu, Y. K. Suen, Winnie W. Y. Chow, S. Y. Wu, W. C. Law, W. Yuan, W. J. Li, S. K. Kong, and Chinlon Lin  »View Author Affiliations


Applied Optics, Vol. 46, Issue 12, pp. 2325-2332 (2007)
http://dx.doi.org/10.1364/AO.46.002325


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Abstract

We present a biosensor design based on capturing the two-dimenstional (2D) phase image of surface plasmon resonance (SPR). This 2D SPR imaging technique may enable parallel label-free detection of multiple analytes and is compatible with the microarray chip platform. This system uses our previously reported differential phase measurement approach, in which 2D phase maps obtained from the signal (P) and reference (S) polarizations are compared pixel by pixel. This technique greatly improves detection resolution as the subtraction step can eliminate measurement fluctuations caused by external disturbances as they essentially appear in both channels. Unlike conventional angular SPR systems, in which illumination from a range of angles must be used, phase measurement requires illumination from only one angle, thus making it well suited for 2D measurement. Also, phase-stepping introduced from a moving mirror provides the necessary modulation for accurate detection of the phase. In light of the rapidly increasing need for fast real-time detection, quantification, and identification of a range of proteins for various biomedical applications, our 2D SPR phase imaging technique should hold a promising future in the medical device market.

© 2007 Optical Society of America

OCIS Codes
(170.0110) Medical optics and biotechnology : Imaging systems
(240.6680) Optics at surfaces : Surface plasmons

ToC Category:
Imaging Systems

History
Original Manuscript: September 6, 2006
Revised Manuscript: November 30, 2006
Manuscript Accepted: December 1, 2006
Published: April 3, 2007

Virtual Issues
Vol. 2, Iss. 5 Virtual Journal for Biomedical Optics

Citation
C. L. Wong, H. P. Ho, T. T. Yu, Y. K. Suen, Winnie W. Y. Chow, S. Y. Wu, W. C. Law, W. Yuan, W. J. Li, S. K. Kong, and Chinlon Lin, "Two-dimensional biosensor arrays based on surface plasmon resonance phase imaging," Appl. Opt. 46, 2325-2332 (2007)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=ao-46-12-2325


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References

  1. D. Kambhampati, Protein Microarray Technology (Wiley-VCH, 2004).
  2. N. Zammatteo, L. Jeanmart, S. Hamels, S. Courtois, P. Louette, L. Hevesi, and J. Remacle, "Comparison between different strategies of covalent attachment of DNA to glass surfaces to build DNA microarrays," Anal. Biochem. 280, 143-150 (2000). [PubMed]
  3. A. Ulman, "Formation and structure of self-assembled monolayers," Chem. Rev. 96, 1533-1554 (1996). [PubMed]
  4. K. L. Prime and G. M. Whitesides, "Self-assembled organic monolayers: model systems for studying adsorption of proteins at surfaces," Science 252, 1164-1167 (1991). [PubMed]
  5. J. Homola, S. S. Yee, and G. Gauglitz, "Surface plasmon resonance sensors: review," Sens. Actuators B 54, 3-15 (1999).
  6. J. Homola, "Present and future of surface plasmon resonance biosensors (review)," Anal. Bioanal. Chem. 377, 528-539 (2003). [PubMed]
  7. E. Yeatman and E. Ash, "Surface plasmon microscopy," Electron. Lett. 23, 1091-1092 (1987).
  8. B. Rothenhäusler and W. Knoll, "Surface-plasmon microscopy," Nature 332, 615-617 (1988).
  9. C. E. Jordan and R. M. Corn, "Surface plasmon resonance imaging measurements of electrostatic biopolymer adsorption onto chemically modified gold surfaces," Anal. Chem. 69, 1449-1456 (1997). [PubMed]
  10. E. A. Smith, M. G. Erickson, A. T. Ulijasz, B. Weisblum, and R. M. Corn, "Surface plasmon resonance imaging of transcription factor proteins: interactions of bacterial response regulators with DNA arrays on gold films," Langmuir 19, 1486-1492 (2003).
  11. E. A. Smith, M. Kyo, H. Kumasawa, K. Nakatani, I. Saito, and R. M. Corn, "Chemically induced hairpin formulation in DNA monolayers," J. Am. Chem. Soc. 124, 6810-6811 (2002). [PubMed]
  12. H. J. Lee, T. T. Goodrich, and R. M. Corn, "SPR imaging measurement of 1-D and 2-D DNA microarrays created from microfluidic channels on gold thin films," Anal. Chem. 73, 5525-5531 (2001).
  13. G. J. Wegner, H. J. Lee, and R. M. Corn, "Characterization and optimization of peptide arrays for the study of epitope-antibody interactions using surface plasmon resonance imaging," Anal. Chem. 74, 5161-5168 (2002). [PubMed]
  14. G. J. Wegner, H. J. Lee, G. Marriott, and R. M. Corn, "Fabrication of histidine-tagged fusion protein arrays for surface plasmon resonance imaging studies of protein-protein and protein-DNA interactions," Anal. Chem. 75, 4740-4746 (2003). [PubMed]
  15. E. A. Smith, W. D. Thomas, L. L. Kiessling, and R. M. Corn, "Surface plasmon resonance imaging studies of protein-carbohydrate interactions," J. Am. Chem. Soc. 125, 6140-6148 (2003). [PubMed]
  16. S. G. Nelson, K. S. Johnston, and S. S. Yee, "High sensitivity surface plasmon resonace sensor based on phase detection," Sens. Actuators B 35, 187-191 (1996).
  17. P. I. Nikitin, A. N. Grigorenko, A. A. Beloglazov, M. V. Valeiko, A. I. Savchuk, O. A. Savchuk, G. Steiner, C. Kuhne, A. Huebner, and R. Salzer, "Surface plasmon resonance interferometry for micro-array biosensing," Sens. Actuators A 85, 189-193 (2000).
  18. H. P. Ho and W. W. Lam, "Application of differential phase measurement technique to surface plasmon resonance sensors," Sens. Actuators B 96, 554-559 (2003).
  19. Y. Xinglong, W. Dingxin, W. Xing, D. Xiang, L. Wei, and Z. Xinsheng, "A surface plasmon resonance imaging interferometry for protein micro-array detection," Sens. Actuators B 108, 765-771 (2005).
  20. S. Y. Wu, H. P. Ho, W. C. Law, C. Lin, and S. K. Kong, "Highly sensitive differential phase-sensitive surface plasmon resonance (SPR) biosensor based on Mach-Zehnder configuration," Opt. Lett. 29, 2378-2381 (2004). [PubMed]
  21. B.-HJo, L. M. Van Lerberghe, K. M. Motsegood, and D. J. Beebe, "Three-dimensional micro-channel fabrication in polydimethylsiloxane (PDMS) elastomer," J. Microelectromech. Syst. 9, 76-81 (2000).
  22. R. C. Weast, ed. CRC Handbook of Chemistry and Physics, 68th ed. (CRC, 1987).

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