Polarization-sensitive optical coherence tomography (PS-OCT) combines the advantages of OCT with image contrast enhancement, which is based on its ability to detect phase retardation and the fast-axis angle. Both PS-OCT images and histopathology have demonstrated similar features that allowed differentiation of atherosclerotic structures (i.e., plaques) from normal tissue. Moreover, the picrosirius polarization method was used to confirm PS-OCT assessment of collagen in the fibrous cap of atherosclerotic plaques, and high-frequency (40 MHz) ultrasound images were used to identify calcium in the vessel wall. Our preliminary ex vivo investigation of human aortic specimens indicated that PS-OCT might help to identify atherosclerotic lesions.
© 2007 Optical Society of America
Original Manuscript: October 3, 2006
Manuscript Accepted: November 16, 2006
Published: April 9, 2007
Vol. 2, Iss. 6 Virtual Journal for Biomedical Optics
Wen-Chuan Kuo, Nai-Kuan Chou, Chien Chou, Chih-Ming Lai, Huan-Jang Huang, Shoei-Shen Wang, and Jeou-Jong Shyu, "Polarization-sensitive optical coherence tomography for imaging human atherosclerosis," Appl. Opt. 46, 2520-2527 (2007)