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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics


  • Editor: Gregory W. Faris
  • Vol. 2, Iss. 6 — Jun. 13, 2007

Intraoperative monitoring of depth-dependent hemoglobin concentration changes during carotid endarterectomy by time-resolved spectroscopy

Chie Sato, Takekane Yamaguchi, Mitsuru Seida, Yoshihisa Ota, Iwae Yu, Yoshinobu Iguchi, Masahito Nemoto, and Yoko Hoshi  »View Author Affiliations

Applied Optics, Vol. 46, Issue 14, pp. 2785-2792 (2007)

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By measuring the adult human head during carotid endarterectomy, we investigate the depth sensitivity of two methods for deriving the absorption coefficient changes ( Δ μ a ) from time-resolved reflectance data to absorption changes in inhomogeneous media: (1) the curve-fitting method based on the diffusion equation (DE-fit method) and (2) the time-independent calculation based on the modified Lambert–Beer law (MLB method). Remarkable differences in the determined values of Δ μ a caused by clamping the external carotid artery and subsequently clamping the common carotid artery were observed between the methods. The DE-fit method was more sensitive to μ a changes in cerebral tissues, whereas the MLB method was rather sensitive to μ a changes in the extracerebral tissues. Our results indicated that the DE-fit was useful for monitoring the cerebral blood circulation and oxygenation during neurosurgical operations. In addition, the combined evaluation of μ a changes with the DE-fit and MLB methods will provide us with more available information about the hemodynamic changes in the depth direction.

© 2007 Optical Society of America

OCIS Codes
(170.1610) Medical optics and biotechnology : Clinical applications
(170.3660) Medical optics and biotechnology : Light propagation in tissues
(170.6510) Medical optics and biotechnology : Spectroscopy, tissue diagnostics
(300.6500) Spectroscopy : Spectroscopy, time-resolved

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: October 31, 2006
Manuscript Accepted: December 22, 2006
Published: April 23, 2007

Virtual Issues
Vol. 2, Iss. 6 Virtual Journal for Biomedical Optics

Chie Sato, Takekane Yamaguchi, Mitsuru Seida, Yoshihisa Ota, Iwae Yu, Yoshinobu Iguchi, Masahito Nemoto, and Yoko Hoshi, "Intraoperative monitoring of depth-dependent hemoglobin concentration changes during carotid endarterectomy by time-resolved spectroscopy," Appl. Opt. 46, 2785-2792 (2007)

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  1. G. Zaccanti, D. Contini, M. Guriori, A. Ismaelli, H. Liszka, and A. Sassaroli, "Detectability of inhomogeneities within highly diffusing media," Proc. SPIE 2389, 755-762 (1995).
  2. M. Kohl-Bareis, H. Obrig, J. Steinbrink, J. Malak, K. Uludag, and A. Villringer, "Noninvasive monitoring of cerebral blood flow by a dye bolus method: separation of brain from skin and skull signals," J. Biomed. Opt. 7, 464-470 (2002). [CrossRef] [PubMed]
  3. A. Liebert, H. Wabnitz, J. Steinbrink, M. Moller, R. Macdonald, H. Rinneberg, A. Villringer, and H. Obrig, "Bedside assessment of cerebral perfusion in stroke patients based on optical monitoring of a dye bolus by time-resolved diffuse reflectance," Neuroimage 24, 426-435 (2005). [CrossRef] [PubMed]
  4. M. S. Patterson, B. Chance, and B. C. Wilson, "Time resolved reflectance and transmittance for the noninvasive measurement of tissue optical properties," Appl. Opt. 28, 2331-2336 (1989). [CrossRef] [PubMed]
  5. A. H. Hielscher, H. Liu, B. Chance, F. K. Tittel, and S. L. Jacques, "Time-resolved photon emission from layered turbid media," Appl. Opt. 35, 719-728 (1996). [CrossRef] [PubMed]
  6. F. Martelli, S. Del Bianco, G. Zaccanti, A. Pifferi, A. Torricelli, A. Bassi, P. Taroni, and R. Cubeddu, "Phantom validation and in vivo application of an inversion procedure for retrieving the optical properties of diffusive layered media from time-resolved reflectance measurements," Opt. Lett. 29, 2037-2039 (2004). [CrossRef] [PubMed]
  7. M. Oda, Y. Yamashita, T. Nakano, A. Suzuki, K. Shimizu, I. Hirano, F. Shimomura, E. Ohmae, T. Suzuki, and Y. Tsuchiya, "Near-infrared time-resolved spectroscopy system for tissue oxygenation monitor," Proc. SPIE 3579, 611-617 (1999).
  8. R. C. Haskell, L. O. Svaasand, T.-T. Tsay, T.-C. Feng, M. S. McAdams, and B. J. Tromberg, "Boundary condition for the diffusion equation in radiative transfer," J. Opt. Soc. Am. A 11, 2727-2741 (1994). [CrossRef]
  9. A. H. Hielscher, S. L. Jacques, L. Wang, and F. K. Tittel, "The influence of boundary conditions on the accuracy of diffusion theory in time-resolved reflectance spectroscopy of biological tissues," Phys. Med. Biol. 40, 1957-1975 (1995). [CrossRef] [PubMed]
  10. K. Furutsu and Y. Yamada, "Diffusion approximation for a dissipative random medium and the applications," Phys. Rev. E 50, 3634-3640 (1994). [CrossRef]
  11. H. Zhang, M. Miwa, T. Urakami, Y. Yamashita, and Y. Tsuchiya, "Simple subtraction method for determining the mean path length traveled by photons in turbid media," Jpn. J. Appl. Phys. Part 1 37, 700-704 (1998). [CrossRef]
  12. M. Firbank, E. Okada, and D. T. Delpy, "A theoretical study of the signal contribution of regions of the adult head to near-infrared spectroscopy studies of visual evoked responses," Neuroimage 8, 69-78 (1998). [CrossRef] [PubMed]
  13. Y. Hoshi, M. Shimada, C. Sato, and Y. Iguchi, "Re-evaluation of near-infrared light propagation in the adult human head: implications for functional near-infrared spectroscopy," J. Biomed. Opt. 10, 064032 (2005). [CrossRef]
  14. C. Sato, Y. Hoshi, M. Shimada, T. Yamaguchi, M. Seida, Y. Ohta, and Y. Yu, "Intraoperative monitoring of depth dependent hemoglobin concentration changes during CEA by time-resolved reflectance," in Biomedical Optics, 2006 OSA Technical Digest (Optical Society of America, 2006), paper ThG1. [PubMed]
  15. F. Fabbri, A. Sassaroli, M. E. Henry, and S. Fantini, "Optical measurements of absorption changes in two-layered diffusive media," Phys. Med. Biol. 49, 1183-1201 (2004). [CrossRef] [PubMed]
  16. T. J. Farrell, M. S. Patterson, and M. Essenpreis, "Influence of layered tissue architecture on estimates of tissue optical properties obtained from spatially resolved diffuse reflectometry," Appl. Opt. 37, 1958-1972 (1998). [CrossRef]
  17. R. J. Hunter, M. S. Patterson, T. J. Farrell, and J. E. Hayward, "Haemoglobin oxygenation of a two-layer tissue-simulating phantom from time-resolved reflectance: effect of top layer thickness," Phys. Med. Biol. 47, 193-208 (2002). [CrossRef] [PubMed]
  18. A. Kienle, M. S. Patterson, N. Dögnitz, R. Bays, G. Wagnières, and H. van den Bergh, "Noninvasive determination of the optical properties of two-layered turbid media," Appl. Opt. 37, 779-791 (1998). [CrossRef]
  19. A. Kienle, M. S. Patterson, "Improved solution of the steady-state and time-resolved diffusion equations for reflectance from a semi-infinite turbid media," J. Opt. Soc. Am. A 14, 246-254 (1997). [CrossRef]
  20. V. Ntziachristos and B. Chance, "Accuracy limits in the determination of absolute optical properties using time-resolved NIR spectroscopy," Med. Phys. 28, 1115-1124 (2001). [CrossRef] [PubMed]
  21. P. G. Al-Rawi, P. Smielewski, and P. J. Kirkpatrick, "Evaluation of a near-infrared spectrometer (NIRO 300) for the detection of intracranial oxygenation changes in the adult head," Stroke 32, 2492-2500 (2001). [CrossRef] [PubMed]
  22. S. Kuroda, K. Houkin, H. Abe, Y. Hoshi, and M. Tamura, "Near-infrared monitoring of cerebral oxygenation state during carotid endarterectomy," Surg. Neurol. 45, 450-458 (1996). [CrossRef] [PubMed]

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