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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editor: Gregory W. Faris
  • Vol. 2, Iss. 6 — Jun. 13, 2007

Use of polar decomposition for the diagnosis of oral precancer

Jungrae Chung, Woonggyu Jung, Marie J. Hammer-Wilson, Petra Wilder-Smith, and Zhongping Chen  »View Author Affiliations


Applied Optics, Vol. 46, Issue 15, pp. 3038-3045 (2007)
http://dx.doi.org/10.1364/AO.46.003038


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Abstract

The Mueller matrix describes all the polarizing properties of a sample and, therefore, the optical differences between noncancerous and precancerous tissue that may be present within the matrix elements. A high-speed polarimetry system that generates 16 ( 4 × 4 ) full Mueller matrices to characterize tissues is presented. Feature extraction is done on the Mueller matrix elements resulting in depolarization and retardance images by polar decomposition. These are used to detect and classify early oral cancers and precancerous changes in epithelium such as dysplasia. These images are compared with orthogonal polarization images and analyzed in an attempt to identity useful factors for the differentiation between cancerous lesions and their benign counterparts. Our results indicate that polarimetry has potential as a method for the in vivo early detection and diagnosis of oral premalignancy.

© 2007 Optical Society of America

OCIS Codes
(170.3890) Medical optics and biotechnology : Medical optics instrumentation
(230.0230) Optical devices : Optical devices
(230.5440) Optical devices : Polarization-selective devices
(290.7050) Scattering : Turbid media

ToC Category:
Optical Devices

History
Original Manuscript: June 29, 2006
Revised Manuscript: December 13, 2006
Manuscript Accepted: January 5, 2007
Published: May 1, 2007

Virtual Issues
Vol. 2, Iss. 6 Virtual Journal for Biomedical Optics

Citation
Jungrae Chung, Woonggyu Jung, Marie J. Hammer-Wilson, Petra Wilder-Smith, and Zhongping Chen, "Use of polar decomposition for the diagnosis of oral precancer," Appl. Opt. 46, 3038-3045 (2007)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=ao-46-15-3038

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