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Virtual Journal for Biomedical Optics


  • Editor: Gregory W. Faris
  • Vol. 2, Iss. 8 — Aug. 10, 2007

Real-time, ultralow concentration detection of analytes in solution by infrared intracavity laser absorption

Untzizu Elejalde and John M. Girkin  »View Author Affiliations

Applied Optics, Vol. 46, Issue 19, pp. 3995-3999 (2007)

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Two intracavity laser absorption techniques for ultralow concentration detection of chemicals in solution are compared. The first consists of a laser diode in a grating extended cavity, which produces a linear calibration curve for parts in 10 9 (ppb) concentrations corresponding to 17   nM . By replacing the grating with a highly reflective mirror, parts in 10 12 (ppt) concentration detection is achieved, which corresponds to 340   pM . We report, to our knowledge for the first time, ppt detection of analyte concentration in liquid solution demonstrating good agreement between theory and experiment.

© 2007 Optical Society of America

OCIS Codes
(120.1880) Instrumentation, measurement, and metrology : Detection
(300.1030) Spectroscopy : Absorption
(300.6260) Spectroscopy : Spectroscopy, diode lasers

ToC Category:
Absorption and Cavity-Based Techniques

Original Manuscript: September 18, 2006
Revised Manuscript: February 15, 2007
Manuscript Accepted: February 28, 2007
Published: June 12, 2007

Virtual Issues
Vol. 2, Iss. 8 Virtual Journal for Biomedical Optics

Untzizu Elejalde and John M. Girkin, "Real-time, ultralow concentration detection of analytes in solution by infrared intracavity laser absorption," Appl. Opt. 46, 3995-3999 (2007)

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