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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editor: Gregory W. Faris
  • Vol. 2, Iss. 8 — Aug. 10, 2007

Method for recovering quantitative broadband diffuse optical spectra from layered media

Ang Li, Richard Kwong, Albert Cerussi, Sean Merritt, Carole Hayakawa, and Bruce Tromberg  »View Author Affiliations


Applied Optics, Vol. 46, Issue 21, pp. 4828-4833 (2007)
http://dx.doi.org/10.1364/AO.46.004828


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Abstract

We report the recovery of broadband ( 650 1000   nm ) diffuse optical absorption and reduced scattering spectra stratified by layer in a two-layer phantom. The broadband optical properties of the phantom featured top and bottom layers designed to simulate adipose and muscle, respectively. The absolute value and dynamic variation of chromophore concentrations in both layers (top layer thickness greater than 5   mm ) were calculated with an average 10% error and 3% error, respectively. In addition to spectra, the algorithm recovers the top layer thickness up to 12   mm within 10% error. It is insensitive to initial guesses of both layers' optical properties as long as the layer thickness initial guess is within ± 2   mm .

© 2007 Optical Society of America

OCIS Codes
(170.3660) Medical optics and biotechnology : Light propagation in tissues
(170.4580) Medical optics and biotechnology : Optical diagnostics for medicine
(170.5280) Medical optics and biotechnology : Photon migration
(170.6510) Medical optics and biotechnology : Spectroscopy, tissue diagnostics

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: October 11, 2006
Revised Manuscript: February 15, 2007
Manuscript Accepted: March 29, 2007
Published: July 6, 2007

Virtual Issues
Vol. 2, Iss. 8 Virtual Journal for Biomedical Optics

Citation
Ang Li, Richard Kwong, Albert Cerussi, Sean Merritt, Carole Hayakawa, and Bruce Tromberg, "Method for recovering quantitative broadband diffuse optical spectra from layered media," Appl. Opt. 46, 4828-4833 (2007)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=ao-46-21-4828


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References

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