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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editor: Gregory W. Faris
  • Vol. 2, Iss. 11 — Nov. 26, 2007

Analytical model of light reflectance for extraction of the optical properties in small volumes of turbid media

Roberto Reif, Ousama A'Amar, and Irving J. Bigio  »View Author Affiliations


Applied Optics, Vol. 46, Issue 29, pp. 7317-7328 (2007)
http://dx.doi.org/10.1364/AO.46.007317


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Abstract

Monte Carlo simulations and experiments in tissue phantoms were used to empirically develop an analytical model that characterizes the reflectance spectrum in a turbid medium. The model extracts the optical properties (scattering and absorption coefficients) of the medium at small source-detector separations, for which the diffusion approximation is not valid. The accuracy of the model and the inversion algorithm were investigated and validated. Four fiber probe configurations were tested for which both the source and the detector fibers were tilted at a predetermined angle, with the fibers parallel to each other. This parallel-fiber geometry facilitates clinical endoscopic applications and ease of fabrication. Accurate extraction of tissue optical properties from in vivo spectral measurements could have potential applications in detecting, noninvasively and in real time, epithelial (pre)cancers.

© 2007 Optical Society of America

OCIS Codes
(170.3660) Medical optics and biotechnology : Light propagation in tissues
(170.3890) Medical optics and biotechnology : Medical optics instrumentation
(170.4580) Medical optics and biotechnology : Optical diagnostics for medicine
(170.6510) Medical optics and biotechnology : Spectroscopy, tissue diagnostics
(170.7050) Medical optics and biotechnology : Turbid media

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: April 9, 2007
Revised Manuscript: August 4, 2007
Manuscript Accepted: August 22, 2007
Published: October 9, 2007

Virtual Issues
Vol. 2, Iss. 11 Virtual Journal for Biomedical Optics

Citation
Roberto Reif, Ousama A'Amar, and Irving J. Bigio, "Analytical model of light reflectance for extraction of the optical properties in small volumes of turbid media," Appl. Opt. 46, 7317-7328 (2007)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=ao-46-29-7317

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